Search Results - "Waterman, Marian"

TCF/LEFs and Wnt signaling in the nucleus by Cadigan, Ken M, Waterman, Marian L

“…T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end point mediators of Wnt/Wingless signaling throughout metazoans…”
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Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer by Pate, Kira T, Stringari, Chiara, Sprowl-Tanio, Stephanie, Wang, Kehui, TeSlaa, Tara, Hoverter, Nate P, McQuade, Miriam M, Garner, Chad, Digman, Michelle A, Teitell, Michael A, Edwards, Robert A, Gratton, Enrico, Waterman, Marian L

“…Much of the mechanism by which Wnt signaling drives proliferation during oncogenesis is attributed to its regulation of the cell cycle. Here, we show how…”
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Inhibition of nuclear Wnt signalling: challenges of an elusive target for cancer therapy by Lyou, Yung, Habowski, Amber N, Chen, George T, Waterman, Marian L

“…The highly conserved Wnt signalling pathway plays an important role in embryonic development and disease pathogenesis, most notably cancer. The ‘canonical’ or…”
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Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis by Vu, Tam, Vallmitjana, Alexander, Gu, Joshua, La, Kieu, Xu, Qi, Flores, Jesus, Zimak, Jan, Shiu, Jessica, Hosohama, Linzi, Wu, Jie, Douglas, Christopher, Waterman, Marian L., Ganesan, Anand, Hedde, Per Niklas, Gratton, Enrico, Zhao, Weian

“…Multiplexed mRNA profiling in the spatial context provides new information enabling basic research and clinical applications. Unfortunately, existing spatial…”
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Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH by Stringari, Chiara, Edwards, Robert A., Pate, Kira T., Waterman, Marian L., Donovan, Peter J., Gratton, Enrico

“…There is a lack of fast and high resolution methods to measure metabolic activity of single cells in their native environment. Here we develop a…”
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NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer by SIKANDAR, Shaheen S, PATE, Kira T, ANDERSON, Scott, DIZON, Diana, EDWARDS, Robert A, WATERMAN, Marian L, LIPKIN, Steven M

“…NOTCH signaling is critical for specifying the intestinal epithelial cell lineage and for initiating colorectal adenomas and colorectal cancers (CRC). Based on…”
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Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression by Arce, Laura, Pate, Kira T, Waterman, Marian L

“…Drosophila Groucho and its human Transducin-like-Enhancer of Split orthologs (TLEs) function as transcription co-repressors within the context of Wnt…”
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Quantitative Profiling of In Vivo-assembled RNA-Protein Complexes Using a Novel Integrated Proteomic Approach by Tsai, Becky Pinjou, Wang, Xiaorong, Huang, Lan, Waterman, Marian L.

“…Identification of proteins in RNA-protein complexes is an important step toward understanding regulation of RNA-based processes. Because of the lack of…”
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An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy by Hachey, Stephanie J, Movsesyan, Silva, Nguyen, Quy H, Burton-Sojo, Giselle, Tankazyan, Ani, Wu, Jie, Hoang, Tuyen, Zhao, Da, Wang, Shuxiong, Hatch, Michaela M, Celaya, Elizabeth, Gomez, Samantha, Chen, George T, Davis, Ryan T, Nee, Kevin, Pervolarakis, Nicholas, Lawson, Devon A, Kessenbrock, Kai, Lee, Abraham P, Lowengrub, John, Waterman, Marian L, Hughes, Christopher C W

“…Around 95% of anti-cancer drugs that show promise during preclinical study fail to gain FDA-approval for clinical use. This failure of the preclinical pipeline…”
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LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells by Morgan, Rhys G, Ridsdale, Jenna, Payne, Megan, Heesom, Kate J, Wilson, Marieangela C, Davidson, Andrew, Greenhough, Alexander, Davies, Sara, Williams, Ann C, Blair, Allison, Waterman, Marian L, Tonks, Alex, Darley, Richard L

“…Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is…”
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Characterization of a chromatin‐associated TCF7L1 complex in human embryonic stem cells by Vuong, Linh M., Pan, Songqin, Sierra, Robert A., Waterman, Marian L., Gershon, Paul D., Donovan, Peter J.

“…Human embryonic stem cells (hESCs) resemble the pluripotent epiblast cells found in the early postimplantation human embryo and represent the “primed” state of…”
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Wnt signaling and colon carcinogenesis: beyond APC by Najdi, Rani, Holcombe, Randall F, Waterman, Marian L

“…Activation of the Wnt signaling pathway via mutation of the adenomatous polyposis coli gene (APC) is a critical event in the development of colon cancer. For…”
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A three-dimensional in vitro model of tumor cell intravasation by Ehsan, Seema M, Welch-Reardon, Katrina M, Waterman, Marian L, Hughes, Christopher C W, George, Steven C

“…Metastasis is the cause of over 90% of all human cancer deaths. Early steps in the metastatic process include: the formation of new blood vessels, the…”
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A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities by Najdi, Rani, Proffitt, Kyle, Sprowl, Stephanie, Kaur, Simran, Yu, Jia, Covey, Tracy M., Virshup, David M., Waterman, Marian L.

“…Wnt ligands are secreted morphogens that control multiple developmental processes during embryogenesis and adult homeostasis. A diverse set of receptors and…”
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Blending Hippo and WNT: Sharing Messengers and Regulation by Tsai, Becky P., Hoverter, Nate P., Waterman, Marian L.

“…Two new studies reveal ways in which the Wnt pathway commandeers Hippo components for signaling. Azzolin et al. show how the Hippo transcription factor TAZ…”
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Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer by Lee, Mary, Chen, George T, Puttock, Eric, Wang, Kehui, Edwards, Robert A, Waterman, Marian L, Lowengrub, John

“…Cell‐intrinsic metabolic reprogramming is a hallmark of cancer that provides anabolic support to cell proliferation. How reprogramming influences tumor…”
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A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease by Hachey, Stephanie J., Sobrino, Agua, Lee, John G., Jafari, Mehraneh D., Klempner, Samuel J., Puttock, Eric J., Edwards, Robert A., Lowengrub, John S., Waterman, Marian L., Zell, Jason A., Hughes, Christopher C.W.

“…Accurately modeling tumor biology and testing novel therapies on patient-derived cells is critically important to developing therapeutic regimens personalized…”
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α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer by Tran, Thai Q, Hanse, Eric A, Habowski, Amber N, Li, Haiqing, Ishak Gabra, Mari B, Yang, Ying, Lowman, Xazmin H, Ooi, Amelia M, Liao, Shu Y, Edwards, Robert A, Waterman, Marian L, Kong, Mei

“…Genetic-driven deregulation of the Wnt pathway is crucial but not sufficient for colorectal cancer (CRC) tumourigenesis. Here, we show that environmental…”
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Disruption of β-Catenin-Dependent Wnt Signaling in Colon Cancer Cells Remodels the Microenvironment to Promote Tumor Invasion by Chen, George T, Tifrea, Delia F, Murad, Rabi, Habowski, Amber N, Lyou, Yung, Duong, Madeleine R, Hosohama, Linzi, Mortazavi, Ali, Edwards, Robert A, Waterman, Marian L

“…The recent classification of colon cancer into molecular subtypes revealed that patients with the poorest prognosis harbor tumors with the lowest levels of Wnt…”
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Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells by Vuong, Linh M., Chellappa, Karthikeyani, Dhahbi, Joseph M., Deans, Jonathan R., Fang, Bin, Bolotin, Eugene, Titova, Nina V., Hoverter, Nate P., Spindler, Stephen R., Waterman, Marian L., Sladek, Frances M.

“…The nuclear receptor hepatocyte nuclear factor 4α (HNF4α) is tumor suppressive in the liver but amplified in colon cancer, suggesting that it also might be…”
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