Search Results - "Waterman, David P"

Checkpoint Responses to DNA Double-Strand Breaks by Waterman, David P, Haber, James E, Smolka, Marcus B

“…Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell…”
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CRISPR/Cas9 cleavages in budding yeast reveal templated insertions and strand-specific insertion/deletion profiles by Lemos, Brenda R., Kaplan, Adam C., Bae, Ji Eun, Ferrazzoli, Alexander E., Kuo, James, Anand, Ranjith P., Waterman, David P., Haber, James E.

“…Harnessing CRISPR-Cas9 technology provides an unprecedented ability to modify genomic loci via DNA double-strand break (DSB) induction and repair. We analyzed…”
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A pathway of targeted autophagy is induced by DNA damage in budding yeast by Eapen, Vinay V., Waterman, David P., Bernard, Amélie, Schiffmann, Nathan, Sayas, Enrich, Kamber, Roarke, Lemos, Brenda, Memisoglu, Gonen, Ang, Jessie, Mazella, Allison, Chuartzman, Silvia G., Loewith, Robbie J., Schuldiner, Maya, Denic, Vladimir, Klionsky, Daniel J., Haber, James E.

“…Autophagy plays a central role in the DNA damage response (DDR) by controlling the levels of various DNA repair and checkpoint proteins; however, how the DDR…”
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Live cell monitoring of double strand breaks in S. cerevisiae by Waterman, David P, Zhou, Felix, Li, Kevin, Lee, Cheng-Sheng, Tsabar, Michael, Eapen, Vinay V, Mazzella, Allison, Haber, James E

“…We have used two different live-cell fluorescent protein markers to monitor the formation and localization of double-strand breaks (DSBs) in budding yeast…”
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Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2 by Tsabar, Michael, Eapen, Vinay V, Mason, Jennifer M, Memisoglu, Gonen, Waterman, David P, Long, Marcus J, Bishop, Douglas K, Haber, James E

“…In response to chromosomal double-strand breaks (DSBs), eukaryotic cells activate the DNA damage checkpoint, which is orchestrated by the PI3 kinase-like…”
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The F-BAR protein Hof1 tunes formin activity to sculpt actin cables during polarized growth by Graziano, Brian R, Yu, Hoi-Ying E, Alioto, Salvatore L, Eskin, Julian A, Ydenberg, Casey A, Waterman, David P, Garabedian, Mikael, Goode, Bruce L

“…Asymmetric cell growth and division rely on polarized actin cytoskeleton remodeling events, the regulation of which is poorly understood. In budding yeast,…”
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Proteomic Analysis Identifies Ribosome Reduction as an Effective Proteotoxic Stress Response by Guerra-Moreno, Angel, Isasa, Marta, Bhanu, Meera K., Waterman, David P., Eapen, Vinay V., Gygi, Steven P., Hanna, John

“…Stress responses are adaptive cellular programs that identify and mitigate potentially dangerous threats. Misfolded proteins are a ubiquitous and clinically…”
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Asf1 facilitates dephosphorylation of Rad53 after DNA double-strand break repair by Tsabar, Michael, Waterman, David P, Aguilar, Fiona, Katsnelson, Lizabeth, Eapen, Vinay V, Memisoglu, Gonen, Haber, James E

“…To allow for sufficient time to repair DNA double-stranded breaks (DSBs), eukaryotic cells activate the DNA damage checkpoint. In budding yeast, Rad53…”
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Prime Editing Efficiently and Precisely Corrects Causative Mutation in Chronic Granulomatous Disease, Restoring Myeloid Function: Toward Development of a Prime Edited Autologous Hematopoietic Stem Cell Therapy by Heath, Jack M, Stuart Orenstein, Jacob, Tedeschi, Justin G, Ng, Allen, Collier, Maria D, Kushakji, Julia, Wilhelm, Alan J, Taylor, Andrew, Waterman, David P, De Ravin, Suk See, Malech, Harry L, Anzalone, Andrew V, Duffield, Jeremy S, Gori, Jennifer L

“…Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency characterized by a lack of nicotinamide adenine dinucleotide phosphate (NADPH)…”
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Multiplex Prime Editing and PASSIGE TM for Non-Viral Generation of an Allogeneic CAR-T Cell Product by Pomeroy, Emily J, Anzalone, Andrew V, Podracky, Christopher J, Bloch, Noah B, Chang, Reyna, Dwivedi, Arika A, Laoharawee, Kanut, Wilhelm, Alan J, Waterman, David P, Tedeschi, Justin G, Arvindam, Upasana Sunil, Macari, Elizabeth R, Gori, Jennifer L, Duffield, Jeremy S

“…While CAR-T cell therapy represents a major advance in personalized immunotherapy, the autologous nature of commercially available CAR-T products have delayed…”
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