Search Results - "Waterman, Clare"

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch by Case, Lindsay B., Waterman, Clare M.

“…Case and Waterman discuss how integrating extracellular-matrix-bound integrins and the actin cytoskeleton into a mechanosensitive molecular clutch transmits…”
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Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration by Plotnikov, Sergey V., Pasapera, Ana M., Sabass, Benedikt, Waterman, Clare M.

“…Cell migration toward areas of higher extracellular matrix (ECM) rigidity via a process called “durotaxis” is thought to contribute to development, immune…”
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Cellular Mechanisms of NETosis by Thiam, Hawa Racine, Wong, Siu Ling, Wagner, Denisa D, Waterman, Clare M

“…Neutrophils are critical to innate immunity, including host defense against bacterial and fungal infections. They achieve their host defense role by…”
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Physical Constraints and Forces Involved in Phagocytosis by Jaumouillé, Valentin, Waterman, Clare M

“…Phagocytosis is a specialized process that enables cellular ingestion and clearance of microbes, dead cells and tissue debris that are too large for other…”
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Coupling of β2 integrins to actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis by Jaumouillé, Valentin, Cartagena-Rivera, Alexander X., Waterman, Clare M.

“…α M β 2 integrin (complement receptor 3) is a major receptor for phagocytosis in macrophages. In other contexts, integrins’ activities and functions are…”
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The molecular clutch model for mechanotransduction evolves by Swaminathan, Vinay, Waterman, Clare M.

“…Many biological processes are influenced by the mechanical rigidity of surrounding tissues. Now, a combination of experiments and mathematical modelling has…”
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NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture by Thiam, Hawa Racine, Wong, Siu Ling, Qiu, Rong, Kittisopikul, Mark, Vahabikashi, Amir, Goldman, Anne E., Goldman, Robert D., Wagner, Denisa D., Waterman, Clare M.

“…Neutrophil extracellular traps (NETs) are web-like DNA structures decorated with histones and cytotoxic proteins that are released by activated neutrophils to…”
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YAP Nuclear Localization in the Absence of Cell-Cell Contact Is Mediated by a Filamentous Actin-dependent, Myosin II- and Phospho-YAP-independent Pathway during Extracellular Matrix Mechanosensing by Das, Arupratan, Fischer, Robert S., Pan, Duojia, Waterman, Clare M.

“…Cell-cell contact inhibition and the mechanical environment of cells have both been shown to regulate YAP nuclear localization to modulate cell proliferation…”
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Blebology: principles of bleb-based migration by García-Arcos, Juan Manuel, Jha, Ankita, Waterman, Clare M., Piel, Matthieu

“…Blebs collaborate with other protrusion types for cell motility, sharing common initiation mechanisms.Asymmetric distribution of membrane-cortex linkers and…”
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Mechanical integration of actin and adhesion dynamics in cell migration by Gardel, Margaret L, Schneider, Ian C, Aratyn-Schaus, Yvonne, Waterman, Clare M

“…Directed cell migration is a physical process that requires dramatic changes in cell shape and adhesion to the extracellular matrix. For efficient movement,…”
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Actomyosin Cortical Mechanical Properties in Nonadherent Cells Determined by Atomic Force Microscopy by Cartagena-Rivera, Alexander X., Logue, Jeremy S., Waterman, Clare M., Chadwick, Richard S.

“…The organization of filamentous actin and myosin II molecular motor contractility is known to modify the mechanical properties of the cell cortical actomyosin…”
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Specification of Architecture and Function of Actin Structures by Actin Nucleation Factors by Skau, Colleen T, Waterman, Clare M

“…The actin cytoskeleton is essential for diverse processes in mammalian cells; these processes range from establishing cell polarity to powering cell migration…”
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Guiding cell migration by tugging by Plotnikov, Sergey V, Waterman, Clare M

“…The ability of cells to move directionally toward areas of stiffer extracellular matrix (ECM) via a process known as ‘durotaxis’ is thought to be critical for…”
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Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions by Case, Lindsay B., Baird, Michelle A., Shtengel, Gleb, Campbell, Sharon L., Hess, Harald F., Davidson, Michael W., Waterman, Clare M.

“…Focal adhesions (FAs) link the extracellular matrix to the actin cytoskeleton to mediate cell adhesion, migration, mechanosensing and signalling. FAs have…”
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Filopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis by Fischer, Robert S., Lam, Pui-Ying, Huttenlocher, Anna, Waterman, Clare M.

“…Single cell branching during development in vertebrates is typified by neuronal branching to form neurites and vascular branches formed by sprouting…”
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Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation by Pasapera, Ana M, Schneider, Ian C, Rericha, Erin, Schlaepfer, David D, Waterman, Clare M

“…Focal adhesions (FAs) are mechanosensitive adhesion and signaling complexes that grow and change composition in response to myosin II-mediated cytoskeletal…”
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The FAK-Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin by Swaminathan, Vinay, Fischer, R S, Waterman, Clare M

“…Cell migration is initiated in response to biochemical or physical cues in the environment that promote actin-mediated lamellipodial protrusion followed by the…”
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Nanoscale architecture of integrin-based cell adhesions by Davidson, Michael W, Hess, Harald F, Waterman, Clare M, Kanchanawong, Pakorn, Shtengel, Gleb, Pasapera, Ana M, Ramko, Ericka B

“…Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis, immunity and wound healing. Focal adhesions are multifunctional organelles…”
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Mechanosensing through Direct Binding of Tensed F-Actin by LIM Domains by Sun, Xiaoyu, Phua, Donovan Y.Z., Axiotakis, Lucas, Smith, Mark A., Blankman, Elizabeth, Gong, Rui, Cail, Robert C., Espinosa de los Reyes, Santiago, Beckerle, Mary C., Waterman, Clare M., Alushin, Gregory M.

“…Mechanical signals transmitted through the cytoplasmic actin cytoskeleton must be relayed to the nucleus to control gene expression. LIM domains are…”
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Rac1-Dependent Phosphorylation and Focal Adhesion Recruitment of Myosin IIA Regulates Migration and Mechanosensing by Pasapera, Ana M., Plotnikov, Sergey V., Fischer, Robert S., Case, Lindsay B., Egelhoff, Thomas T., Waterman, Clare M.

“…Cell migration requires coordinated formation of focal adhesions (FAs) and assembly and contraction of the actin cytoskeleton. Nonmuscle myosin II (MII) is a…”
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