Search Results - "Waterland, Robert A."

Epigenetic mechanisms affecting regulation of energy balance: many questions, few answers by Waterland, Robert A

“…Extensive human and animal model data show that nutrition and other environmental influences during critical periods of embryonic, fetal, and early postnatal…”
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Assessing the effects of high methionine intake on DNA methylation by Waterland, Robert A

“…Methylation of DNA occurs at cytosines within CpG (cytosine-guanine) dinucleotides and is 1 of several epigenetic mechanisms that serve to establish and…”
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Epigenetic Epidemiology of the Developmental Origins Hypothesis by Waterland, Robert A, Michels, Karin B

“…Extensive human epidemiologic and animal model data indicate that during critical periods of prenatal and postnatal mammalian development, nutrition and other…”
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Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control by Gunasekara, Chathura J, MacKay, Harry, Scott, C Anthony, Li, Shaobo, Laritsky, Eleonora, Baker, Maria S, Grimm, Sandra L, Jun, Goo, Li, Yumei, Chen, Rui, Wiemels, Joseph L, Coarfa, Cristian, Waterland, Robert A

“…Genetic variants can modulate phenotypic outcomes via epigenetic intermediates, for example at methylation quantitative trait loci (mQTL). We present the first…”
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Maternal nutrition at conception modulates DNA methylation of human metastable epialleles by Dominguez-Salas, Paula, Moore, Sophie E., Baker, Maria S., Bergen, Andrew W., Cox, Sharon E., Dyer, Roger A., Fulford, Anthony J., Guan, Yongtao, Laritsky, Eleonora, Silver, Matt J., Swan, Gary E., Zeisel, Steven H., Innis, Sheila M., Waterland, Robert A., Prentice, Andrew M., Hennig, Branwen J.

“…In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the…”
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Assisted reproductive technology alters deoxyribonucleic acid methylation profiles in bloodspots of newborn infants by Estill, Molly S., M.S, Bolnick, Jay M., M.D, Waterland, Robert A., Ph.D, Bolnick, Alan D., M.D, Diamond, Michael P., M.D, Krawetz, Stephen A., Ph.D

“…Objective To evaluate the effect of infertility and intracytoplasmic sperm injection (ICSI) on DNA methylation of offspring. Design Microarray analysis of DNA…”
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Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles by Waterland, Robert A, Kellermayer, Richard, Laritsky, Eleonora, Rayco-Solon, Pura, Harris, R Alan, Travisano, Michael, Zhang, Wenjuan, Torskaya, Maria S, Zhang, Jiexin, Shen, Lanlan, Manary, Mark J, Prentice, Andrew M

“…Throughout most of the mammalian genome, genetically regulated developmental programming establishes diverse yet predictable epigenetic states across…”
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Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity by Kühnen, Peter, Handke, Daniela, Waterland, Robert A., Hennig, Branwen J., Silver, Matt, Fulford, Anthony J., Dominguez-Salas, Paula, Moore, Sophie E., Prentice, Andrew M., Spranger, Joachim, Hinney, Anke, Hebebrand, Johannes, Heppner, Frank L., Walzer, Lena, Grötzinger, Carsten, Gromoll, Jörg, Wiegand, Susanna, Grüters, Annette, Krude, Heiko

“…The estimated heritability of human BMI is close to 75%, but identified genetic variants explain only a small fraction of interindividual body-weight…”
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A genomic atlas of systemic interindividual epigenetic variation in humans by Gunasekara, Chathura J, Scott, C Anthony, Laritsky, Eleonora, Baker, Maria S, MacKay, Harry, Duryea, Jack D, Kessler, Noah J, Hellenthal, Garrett, Wood, Alexis C, Hodges, Kelly R, Gandhi, Manisha, Hair, Amy B, Silver, Matt J, Moore, Sophie E, Prentice, Andrew M, Li, Yumei, Chen, Rui, Coarfa, Cristian, Waterland, Robert A

“…DNA methylation is thought to be an important determinant of human phenotypic variation, but its inherent cell type specificity has impeded progress on this…”
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Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes by Brand, Stephanie, PhD, Teich, René, PhD, Dicke, Tanja, PhD, Harb, Hani, BSc, Yildirim, Ali Ö., MD, Tost, Jörg, PhD, Schneider-Stock, Regine, PhD, Waterland, Robert A., PhD, Bauer, Uta-Maria, PhD, von Mutius, Erika, MD, MSc, Garn, Holger, PhD, Pfefferle, Petra I., PhD, DrPH, Renz, Harald, MD

“…Background Bronchial asthma is a chronic inflammatory disease resulting from complex gene-environment interactions. Natural microbial exposure has been…”
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Identification of cell type-specific methylation signals in bulk whole genome bisulfite sequencing data by Scott, C. Anthony, Duryea, Jack D., MacKay, Harry, Baker, Maria S., Laritsky, Eleonora, Gunasekara, Chathura J., Coarfa, Cristian, Waterland, Robert A.

“…Abstract Background The traditional approach to studying the epigenetic mechanism CpG methylation in tissue samples is to identify regions of concordant…”
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Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome by Yu, Da-Hai, Gadkari, Manasi, Zhou, Quan, Yu, Shiyan, Gao, Nan, Guan, Yongtao, Schady, Deborah, Roshan, Tony N, Chen, Miao-Hsueh, Laritsky, Eleonora, Ge, Zhongqi, Wang, Hui, Chen, Rui, Westwater, Caroline, Bry, Lynn, Waterland, Robert A, Moriarty, Chelsea, Hwang, Cindy, Swennes, Alton G, Moore, Sean R, Shen, Lanlan

“…Background: DNA methylation is an epigenetic mechanism central to development and maintenance of complex mammalian tissues, but our understanding of its role…”
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Ten Putative Contributors to the Obesity Epidemic by McAllister, Emily J, Dhurandhar, Nikhil V, Keith, Scott W, Aronne, Louis J, Barger, Jamie, Baskin, Monica, Benca, Ruth M, Biggio, Joseph, Boggiano, Mary M, Eisenmann, Joe C, Elobeid, Mai, Fontaine, Kevin R, Gluckman, Peter, Hanlon, Erin C, Katzmarzyk, Peter, Pietrobelli, Angelo

“…The obesity epidemic is a global issue and shows no signs of abating, while the cause of this epidemic remains unclear. Marketing practices of energy-dense…”
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Epigenetic supersimilarity of monozygotic twin pairs by Van Baak, Timothy E, Coarfa, Cristian, Dugué, Pierre-Antoine, Fiorito, Giovanni, Laritsky, Eleonora, Baker, Maria S, Kessler, Noah J, Dong, Jianrong, Duryea, Jack D, Silver, Matt J, Saffari, Ayden, Prentice, Andrew M, Moore, Sophie E, Ghantous, Akram, Routledge, Michael N, Gong, Yun Yun, Herceg, Zdenko, Vineis, Paolo, Severi, Gianluca, Hopper, John L, Southey, Melissa C, Giles, Graham G, Milne, Roger L, Waterland, Robert A

“…Monozygotic twins have long been studied to estimate heritability and explore epigenetic influences on phenotypic variation. The phenotypic and epigenetic…”
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Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters by Shen, Lanlan, Kondo, Yutaka, Guo, Yi, Zhang, Jiexin, Zhang, Li, Ahmed, Saira, Shu, Jingmin, Chen, Xinli, Waterland, Robert A, Issa, Jean-Pierre J

“…The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed…”
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Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) and DNA methylation in newborn dried blood spots in the Upstate KIDS cohort by Robinson, Sonia L., Zeng, Xuehuo, Guan, Weihua, Sundaram, Rajeshwari, Mendola, Pauline, Putnick, Diane L., Waterland, Robert A., Gunasekara, Chathura J., Kannan, Kurunthachalam, Gao, Chongjing, Bell, Erin M., Yeung, Edwina H.

“…Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are persistent organic pollutants which may alter prenatal development, potentially through…”
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DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice by MacKay, Harry, Scott, C. Anthony, Duryea, Jack D., Baker, Maria S., Laritsky, Eleonora, Elson, Amanda E., Garland Jr, Theodore, Fiorotto, Marta L., Chen, Rui, Li, Yumei, Coarfa, Cristian, Simerly, Richard B., Waterland, Robert A.

“…DNA methylation regulates cell type-specific gene expression. Here, in a transgenic mouse model, we show that deletion of the gene encoding DNA…”
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Systemic interindividual DNA methylation variants in cattle share major hallmarks with those in humans by Chang, Wen-Jou, Baker, Maria S, Laritsky, Eleonora, Gunasekara, Chathura J, Maduranga, Uditha, Galliou, Justine C, McFadden, Joseph W, Waltemyer, Jessica R, Berggren-Thomas, Bruce, Tate, Brianna N, Zhang, Hanxue, Rosen, Benjamin D, Van Tassell, Curtis P, Liu, George E, Coarfa, Cristian, Ren, Yi Athena, Waterland, Robert A

“…We recently identified ~ 10,000 correlated regions of systemic interindividual epigenetic variation (CoRSIVs) in the human genome. These methylation variants…”
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Maternal methyl supplements increase offspring DNA methylation at Axin fused by Waterland, Robert A., Dolinoy, Dana C., Lin, Juan-Ru, Smith, Charlotte A., Shi, Xin, Tahiliani, Kajal G.

“…Transient environmental exposures during mammalian development can permanently alter gene expression and metabolism by influencing the establishment of…”
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Comparison and quantitative verification of mapping algorithms for whole-genome bisulfite sequencing by Kunde-Ramamoorthy, Govindarajan, Coarfa, Cristian, Laritsky, Eleonora, Kessler, Noah J, Harris, R Alan, Xu, Mingchu, Chen, Rui, Shen, Lanlan, Milosavljevic, Aleksandar, Waterland, Robert A

“…Coupling bisulfite conversion with next-generation sequencing (Bisulfite-seq) enables genome-wide measurement of DNA methylation, but poses unique challenges…”
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