Search Results - "Waterhouse, David J"

Synthesis of Isotopically Labeled Anti-HIV Nucleoside Islatravir through a One-Pot Biocatalytic Cascade Reaction by Ren, Sumei, Huffman, Mark A, Whittaker, Aaron M, Yang, Hao, Nawrat, Christopher C, Waterhouse, David J, Maloney, Kevin M, Strotman, Neil A

“…We report the synthesis of the carbon-14-labeled unnatural nucleoside islatravir, an investigational HIV drug, through a one-pot biocatalytic cascade starting…”
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Moisture determination of tritium tracers utilizing near-infrared spectroscopy by Marques, Rosemary, Waterhouse, David J., Helmy, Roy

“…Tritium tracers are frequently used in biological assays during the drug discovery process because of their high specific activity and relative ease of…”
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JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity by Shami, Paul J, Saavedra, Joseph E, Wang, Lai Y, Bonifant, Challice L, Diwan, Bhalchandra A, Singh, Shivendra V, Gu, Yijun, Fox, Stephen D, Buzard, Gregory S, Citro, Michael L, Waterhouse, David J, Davies, Keith M, Ji, Xinhua, Keefer, Larry K

“…We have previously shown that nitric oxide (NO) inhibits growth and induces differentiation and apoptosis in acute myeloid leukemia cells, with the HL-60 human…”
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PABA/NO as an Anticancer Lead:  Analogue Synthesis, Structure Revision, Solution Chemistry, Reactivity toward Glutathione, and in Vitro Activity by Saavedra, Joseph E, Srinivasan, Aloka, Buzard, Gregory S, Davies, Keith M, Waterhouse, David J, Inami, Keiko, Wilde, Thomas C, Citro, Michael L, Cuellar, Matthew, Deschamps, Jeffrey R, Parrish, Damon, Shami, Paul J, Findlay, Victoria J, Townsend, Danyelle M, Tew, Kenneth D, Singh, Shivendra, Jia, Lee, Ji, Xinhua, Keefer, Larry K

“…PABA/NO is a diazeniumdiolate of structure Me2NN(O)NOAr (where Ar is a 5-substituted-2,4-dinitrophenyl ring whose 5-substituent is N-methyl-p-aminobenzoic…”
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Measuring Seven Endogenous Ketolic Estrogens Simultaneously in Human Urine by High-Performance Liquid Chromatography−Mass Spectrometry by Xu, Xia, Keefer, Larry K, Waterhouse, David J, Saavedra, Joseph E, Veenstra, Timothy D, Ziegler, Regina G

“…A rapid, sensitive, and specific high-performance liquid chromatography-electrospray ionization-multistage mass spectrometry (MS) method for measuring…”
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Chemistry of the Diazeniumdiolates:  Z ⇌ E Isomerism by Wang, Yan-Ni, Bohle, D. Scott, Bonifant, Challice L, Chmurny, Gwendolyn N, Collins, Jack R, Davies, Keith M, Deschamps, Jeffrey, Flippen-Anderson, Judith L, Keefer, Larry K, Klose, John R, Saavedra, Joseph E, Waterhouse, David J, Ivanic, Joseph

“…Here, we explore the chemistry of the previously undocumented E form of diazeniumdiolates having the structure R1R2NN(O)NOR3. Reported crystallographic…”
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Stable isotope dilution high-performance liquid chromatography–electrospray ionization mass spectrometry method for endogenous 2- and 4-hydroxyestrones in human urine by Xu, Xia, Ziegler, Regina G, Waterhouse, David J, Saavedra, Joseph E, Keefer, Larry K

“…A sensitive, precise and accurate stable isotope dilution high-performance liquid chromatography–electrospray ionization mass spectrometry method has been…”
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Injectable formulation of disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), an ultrafast nitric oxide donor prodrug by Waterhouse, David J, Saavedra, Joseph E, Davies, Keith M, Citro, Michael L, Xu, Xia, Powell, Douglas A, Grimes, George J, Potti, Gopal K, Keefer, Larry K

“…PROLI/NO is an agent of structure XN(O)==NONa (X = L-prolyl) whose 2-s half-life for nitric oxide (NO) release at physiological pH makes it an excellent…”
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General Synthetic Pathway to Oxygenated 3-Methylbenz[g]isoquinoline-5,10-diones by Paul Krapcho, A., J. Waterhouse, David

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Qualitative Thin-Layer and High-Performance Liquid Chromatographic Analysis of 1-Substituted Diazen- 1-ium-1,2-diolates on Aminopropyl-Bonded Silica Gel by Fitzhugh, Anthony L., Anadu, Nwanne O., Waterhouse, David J., Hrabie, Joseph A., Saavedra, Joseph E., Keefer, Larry K.

“…High-performance liquid (HPLC) and thin-layer (TLC) chromatographic methods for the detection and quantification of diazeniumdiolates are described. The HPLC…”
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Chemistry of the diazeniumdiolates: Z right harpoon over left harpoon E isomerism by Wang, Yan-Ni, Bohle, D Scott, Bonifant, Challice L, Chmurny, Gwendolyn N, Collins, Jack R, Davies, Keith M, Deschamps, Jeffrey, Flippen-Anderson, Judith L, Keefer, Larry K, Klose, John R, Saavedra, Joseph E, Waterhouse, David J, Ivanic, Joseph

“…Here, we explore the chemistry of the previously undocumented E form of diazeniumdiolates having the structure R(1)R(2)NN(O)=NOR(3). Reported crystallographic…”
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JS-K, a Glutathione/Glutathione S-Transferase-activated Nitric Oxide Donor of the Diazeniumdiolate Class with Potent Antineoplastic Activity1 by Paul J. Shami, Joseph E. Saavedra, Lai Y. Wang, Challice L. Bonifant, Bhalchandra A. Diwan, Shivendra V. Singh, Yijun Gu, Stephen D. Fox, Gregory S. Buzard, Michael L. Citro, David J. Waterhouse, Keith M. Davies, Xinhua Ji, Larry K. Keefer

“…We have previously shown that nitric oxide (NO) inhibits growth and induces differentiation and apoptosis in acute myeloid leukemia cells, with the HL-60 human…”
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Synthesis of 1,4-Dihydropyridines by Regioselective Additions of Benzylic Zinc Bromides to Pyridinium Salts and Their Aromatizations to 4-Benzylpyridines by Krapcho, A. Paul, Waterhouse, David J., Hammach, Abdelhakim, Di Domenico, Roberto, Menta, Ernesto, Oliva, Ambrogio, Spinelli, Silvano

“…Benzylic zinc reagents add with high regioselectivity to 1-(phenoxycarbonyl) salts of methyl nicotinate to yield…”
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