Search Results - "Watenpaugh, Keith D"

Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class by Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Aristoff, Paul A, Johnson, Paul D, Skulnick, Harvey I, Dolak, Lester A, Seest, Eric P, Tomich, Paul K, Bohanon, Michael J, Horng, Miao-Miao, Lynn, Janet C, Chong, Kong-Teck, Hinshaw, Roger R, Watenpaugh, Keith D, Janakiraman, Musiri N, Thaisrivongs, Suvit

“…A broad screening program previously identified phenprocoumon (1) as a small molecule template for inhibition of HIV protease. Subsequent modification of this…”
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The atomic-resolution structure of human caspase-8, a key activator of apoptosis by Watt, William, Koeplinger, Kenneth A, Mildner, Ana M, Heinrikson, Robert L, Tomasselli, Alfredo G, Watenpaugh, Keith D

“…Background: Caspases are a family of cysteine proteases that have important intracellular roles in inflammation and apoptosis. Caspase-8 activates downstream…”
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Structure-Based Design of Novel HIV Protease Inhibitors:  Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors by Thaisrivongs, Suvit, Janakiraman, Musiri N, Chong, Kong-Teck, Tomich, Paul K, Dolak, Lester A, Turner, Steve R, Strohbach, Joseph W, Lynn, Janet C, Horng, Miao-Miao, Hinshaw, Roger R, Watenpaugh, Keith D

“…The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents…”
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Use of Medium-Sized Cycloalkyl Rings To Enhance Secondary Binding: Discovery of a New Class of Human Immunodeficiency Virus (HIV) Protease Inhibitors by Romines, Karen R, Watenpaugh, Keith D, Tomich, Paul K, Howe, W. Jeffrey, Morris, Jeanette K, Lovasz, Kristine D, Mulichak, Anne M, Finzel, Barry C, Lynn, Janet C

“…A unique strategy for the enhancement of secondary binding of an inhibitor to an enzyme has been demonstrated in the design of new human immunodeficiency virus…”
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The Cyclin-dependent Kinases cdk2 and cdk5 Act by a Random, Anticooperative Kinetic Mechanism by Clare, Paula M., Poorman, Roger A., Kelley, Laura C., Watenpaugh, Keith D., Bannow, Carol A., Leach, Karen L.

“…cdk2·cyclin E and cdk5·p25 are two members of the cyclin-dependent kinase family that are potential therapeutic targets for oncology and Alzheimer’s disease,…”
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MIDDLE-CLASS MODERNITY AND THE PERSISTENCE OF THE POLITICS OF NOTABLES IN INTER-WAR SYRIA by Watenpaugh, Keith D.

“…From Paris in June 1928, Edmond Rabbath (1901–91) sent to Saעdallah al-Jabiri (1893–1947) his recently published L'évolution politique de la Syrie sous mandat…”
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Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors by Thaisrivongs, Suvit, Tomich, Paul K, Watenpaugh, Keith D, Chong, Kong-Teck, Howe, W. Jeffrey, Yang, Chih-Ping, Strohbach, Joseph W, Turner, Steve R, McGrath, James P

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Comparison of the crystal structures of a flavodoxin in its three oxidation states at cryogenic temperatures by Watt, W, Tulinsky, A, Swenson, R P, Watenpaugh, K D

“…The focus of this study has been to determine the conformation of the holoprotein of recombinant flavodoxin from Desulfovibrio vulgaris with the FMN in each of…”
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Structure-Based Design of HIV Protease Inhibitors:  Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors by Thaisrivongs, Suvit, Skulnick, Harvey I, Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Johnson, Paul D, Aristoff, Paul A, Judge, Thomas M, Gammill, Ronald B, Morris, Jeanette K, Romines, Karen R, Chrusciel, Robert A, Hinshaw, Roger R, Chong, Kong-Teck, Tarpley, W. Gary, Poppe, Susan M, Slade, David E, Lynn, Janet C, Horng, Miao-Miao, Tomich, Paul K, Seest, Eric P, Dolak, Lester A, Howe, W. Jeffrey, Howard, Gina M, Schwende, Francis J, Toth, Lisa N, Padbury, Guy E, Wilson, Grace J, Shiou, Lihua, Zipp, Gail L, Wilkinson, Karen F, Rush, Bob D, Ruwart, Mary J, Koeplinger, Kenneth A, Zhao, Zhiyang, Cole, Serena, Zaya, Renee M, Kakuk, Thomas J, Janakiraman, Musiri N, Watenpaugh, Keith D

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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors:  The Sulfonamide-Substituted Cyclooctylpyranones by Skulnick, Harvey I, Johnson, Paul D, Aristoff, Paul A, Morris, Jeanette K, Lovasz, Kristine D, Howe, W. Jeffrey, Watenpaugh, Keith D, Janakiraman, Musiri N, Anderson, David J, Reischer, Robert J, Schwartz, Theresa M, Banitt, Lee S, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Dolak, Lester A, Seest, Eric P, Schwende, Francis J, Rush, Bob D, Howard, Gina M, Toth, Lisa N, Wilkinson, Karen R, Kakuk, Thomas J, Johnson, Carol W, Cole, Serena L, Zaya, Renee M, Zipp, Gail L, Possert, Peggy L, Dalga, Robert J, Zhong, Wei-Zhu, Williams, Marta G, Romines, Karen R

“…Recently, cyclooctylpyranone derivatives with m-carboxamide substituents (e.g. 2c) were identified as potent, nonpeptidic HIV protease inhibitors, but these…”
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Cation binding to the integrin CD11b I domain and activation model assessment by Baldwin, Eric T, Sarver, Ronald W, Bryant, Garold L, Curry, Kimberly A, Fairbanks, Michael B, Finzel, Barry C, Garlick, Robert L, Heinrikson, Robert L, Horton, Nancy C, Kelley, Laura-Lee C, Mildner, Ana M, Moon, Joseph B, Mott, John E, Mutchler, Veronica T, Tomich, Che-Shen C, Watenpaugh, Keith D, Wiley, Veronica H

“…Background: The integrin family of cell-surface receptors mediate cell adhesion through interactions with the extracellular matrix or other cell-surface…”
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Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors by Thaisrivongs, Suvit, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Dolak, Lester A, Chong, Kong-Teck, Tomich, Che-Shen C, Tomasselli, Alfredo G, Turner, Steve R

“…The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents…”
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Structure-Based Design of HIV Protease Inhibitors:  5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors by Thaisrivongs, Suvit, Romero, Donna L, Tommasi, Ruben A, Janakiraman, Musiri N, Strohbach, Joseph W, Turner, Steve R, Biles, Carolyn, Morge, Raymond R, Johnson, Paul D, Aristoff, Paul A, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Howe, W. Jeffrey, Finzel, Barry C, Watenpaugh, Keith D

“…From a broad screening program, the 4-hydroxycoumarin phenprocoumon (I) was previously identified as a lead template with HIV protease inhibitory activity. The…”
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“Creating Phantoms”: Zaki al-Arsuzi, the Alexandretta Crisis, and the Formation of Modern Arab Nationalism in Syria by Watenpaugh, Keith D.

“…This quotation may be nothing more than a well-turned phrase by its author, Zaki al-Arsuzi. Nonetheless, it illustrates a dilemma that young men like him faced…”
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Structure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease Inhibitors by Skulnick, Harvey I, Johnson, Paul D, Howe, W. Jeffrey, Tomich, Paul K, Chong, Kong-Teck, Watenpaugh, Keith D, Janakiraman, Musiri N, Dolak, Lester A, McGrath, James P

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Non-peptidic HIV protease inhibitors : C2-SYMMETRY-BASED design of bis-sulfonamide dihydropyrones by JANAKIRAMAN, M. N, WATENPAUGH, K. D, TOMICH, P. K, CHONG, K.-T, TURNER, S. R, TOMMASI, R. A, THAISRIVONGS, S, STROHBACH, J. W

“…Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitors have been previously described. Crystallographic analysis of dihydropyrone sulfonamide…”
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Crystal structure of the catalytic subunit of Cdc25B required for G 2 /M phase transition of the cell cycle 1 1Edited by I. A. Wilson by Reynolds, Ross A, Yem, Anthony W, Wolfe, Cindy L, Deibel, Martin R, Chidester, Constance G, Watenpaugh, Keith D

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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors from a Cyclooctylpyranone Lead Structure by Romines, Karen R, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Lovasz, Kristine D, Morris, Jeanette K, Janakiraman, Musiri N, Lynn, Janet C, Horng, Miao-Miao

“…Recently, the novel cyclooctylpyranone HIV protease inhibitor 1 was identified in our labs, and an X-ray structure of this inhibitor complexed with HIV-2…”
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The structure of rubredoxin at 1.2 A resolution by Watenpaugh, K D, Sieker, L C, Jensen, L H

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Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle by Reynolds, R A, Yem, A W, Wolfe, C L, Deibel, Jr, M R, Chidester, C G, Watenpaugh, K D

“…Cdc25B is a dual specificity phosphatase involved in the control of cyclin-dependent kinases and the progression of cells through the cell cycle. A series of…”
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