Search Results - "Wataya, Y."

Synthesis and Antimalarial Activity of Novel Medium-Sized 1,2,4,5-Tetraoxacycloalkanes by Kim, Hye-Sook, Nagai, Yukiko, Ono, Kanako, Begum, Khurshida, Wataya, Yusuke, Hamada, Yoshiaki, Tsuchiya, Kaoru, Masuyama, Araki, Nojima, Masatomo, McCullough, Kevin J

“…CsOH- or Ag2O-mediated cycloalkylation of (alkylidene)bisperoxides 3 and 1,n-dihaloalkanes (n = 3−8) provided the corresponding medium-sized…”
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1,2,4,5-Tetraoxacycloalkanes: synthesis and antimalarial activity by Masuyama, A, Wu, J-M, Nojima, M, Kim, H-S, Wataya, Y

“…In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the…”
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Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death by Yoshioka, A, Tanaka, S, Hiraoka, O, Koyama, Y, Hirota, Y, Ayusawa, D, Seno, T, Garrett, C, Wataya, Y

“…The mechanism of cytotoxic action of 5-fluorodeoxyuridine (FdUrd) in mouse FM3A cells was investigated. We observed the FdUrd-induced imbalance of…”
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Species-specific PCR detection of malaria parasites by microtiter plate hybridization: clinical study with malaria patients by KIMURA, M, MIYAKE, H, HYE-SOOK KIM, TANABE, M, ARAI, M, KAWAI, S, YAMANE, A, WATAYA, Y

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A Sero‐Epidemiological Survey of Gelatin Sensitization in Young Japanese Children During the 1979–1996 Period by Saito, A., Kumagai, T., Kojima, H., Terai, I., Yamanaka, T., Wataya, Y., Umetsu, M., Umetsu, A., Yano, S.

“…Recently, an increasing number of adverse reactions in children inoculated with live attenuated virus vaccines containing gelatin have been reported. However,…”
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Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells by Koizumi, K, Shimamoto, Y, Azuma, A, Wataya, Y, Matsuda, A, Sasaki, T, Fukushima, M

“…Uridine/cytidine kinase which converts uridine and cytidine to their corresponding monophosphates is a rate-limiting enzyme involved in the salvage pathway of…”
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Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from southern Vietnam by KAWAMOTO, F, MIYAKE, H, ISOMURA, S, WATAYA, Y, KANEKO, O, KIMURA, M, NGUYEN THI DUNG, NGUYEN THE DUNG, LIU, Q, ZHOU, M, LE DUC DAO, KAWAI, S

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Synthesis and Antimalarial Activity of Febrifugine Derivatives by TAKEUCHI, Yasuo, KOIKE, Midori, AZUMA, Kumiko, NISHIOKA, Hiromi, ABE, Hitoshi, KIM, Hye-Sook, WATAYA, Yusuke, HARAYAMA, Takashi

“…The regiosomers (2a, b) of the piperidine ring of febrifugine (1a) and isofebrifugine (1b) were synthesized from 4-allyl-3-piperidone (5). Reduction of 5…”
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A trial for a DNA diagnosis of Plasmodium vivax malaria recently reemerging in the Republic of Korea using microtiter plate hybridization assay by Chai, J Y, Park, Y K, Guk, S M, Oh, K H, Oh, M D, Lee, S H, Kim, H S, Wataya, Y

“…The polymerase chain reaction-based microtiter plate hybridization (PCR-MPH) assay was utilized for a DNA diagnosis of Plasmodium vivax malaria, which has…”
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Detection of Plasmodium falciparum in human blood by a nested polymerase chain reaction by Arai, M, Mizukoshi, C, Kubochi, F, Kakutani, T, Wataya, Y

“…We have developed a simple method for direct detection of Plasmodium falciparum parasites in infected human blood using a nested polymerase chain reaction…”
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Leishmania donovani: Pilot Study for Evaluation of Therapeutic Effects of Inosine Analogs against Amastigotes in Vitro and in Vivo by Morishige, K., Aji, T., Ishii, A., Yasuda, T., Wataya, Y.

“…The inhibition of carbocyclic inosine (C-Ino), 3′-deoxyinosine (3′-dI), and 3′-deoxy-3′-fluoroinosine (3′-FI) to Leishmania donovani amastigotes was examined…”
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A variant of Plasmodium ovale; analysis of its 18S ribosomal RNA gene sequence by Miyake, H, Suwa, S, Kimura, M, Wataya, Y

“…We report here a new variant of human malaria parasite found by comparison of diagnostic results obtained from a new DNA diagnostic method named microtiter…”
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Use of blue cotton for detection of mutagenicity in human feces excreted after ingestion of cooked meat by Hayatsu, H, Hayatsu, T, Wataya, Y

“…Fried ground beef has been shown to contain mutagens, and the major mutagenic component has been identified as 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline…”
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Cytotoxic mechanism of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd) by Wataya, Y, Takenaka, K, Yokogawa, T, Matsuda, A, Sasaki, T, Fukushima, M

“…The molecular mechanism of cell death induced by 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd: Figure 1), a potent inhibitor of RNA synthesis, was…”
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Cytotoxic mechanisms of inhibitor of RNA synthesis, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106) by Yokogawa, T, Takenaka, K, Ogawa, D, Futagami, M, Matsuda, A, Fukushima, M, Kitade, Y, Wataya, Y

“…We investigated the molecular mechanisms of cell death induced by 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106: Figure 1), a potent…”
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DNA diagnosis of falciparum malaria using a double PCR technique: a field trial in the Solomon Islands by Wataya, Y, Arai, M, Kubochi, F, Mizukoshi, C, Kakutani, T, Ohta, N, Ishii, A

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Cytotoxic mechanisms of new antitumor nucleoside analogues, 3'-ethynylcytidine (ECyd) and 3'-ethynyluridine (EUrd) by Kanda, H, Takatori, S, Matsuda, A, Sasaki, T, Tanaka, M, Fukushima, M, Wataya, Y

“…The cytotoxic mechanisms of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd) and 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)uracil (EUrd) were studied…”
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Rhodacyanine Dyes as Antimalarials. 1. Preliminary Evaluation of Their Activity and Toxicity by Takasu, Kiyosei, Inoue, Hiroshi, Kim, Hye-Sook, Suzuki, Makoto, Shishido, Tadao, Wataya, Yusuke, Ihara, Masataka

“…The rhodacyanine dye MKT-077 (1), a potent antitumor agent, was found to possess strong in vitro activity against Plasmodium falciparum and a low cytotoxicity…”
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Interaction of thymidylate synthetase with 5-nitro-2'-deoxyuridylate by Wataya, Y, Matsuda, A, Santi, D V

“…5-Nitro-2'-deoxyuridylate (NO2dUMP) is a potent mechanism-based inhibitor of dTMP synthetase. After formation of a reversible enzymeìnhibitor complex, there…”
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Catalytic Asymmetric Synthesis of Antimalarial Alkaloids Febrifugine and Isofebrifugine and Their Biological Activity by Kobayashi, Shū, Ueno, Masaharu, Suzuki, Ritsu, Ishitani, Haruro, Kim, Hye-Sook, Wataya, Yusuke

“…Antimalarial alkaloids febrifugine (1) and isofebrifugine (2) were efficiently synthesized from simple achiral starting materials on the basis of the catalytic…”
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