Search Results - "Watari, Hirofumi"

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease by Arnoux, Isabelle, Willam, Michael, Griesche, Nadine, Krummeich, Jennifer, Watari, Hirofumi, Offermann, Nina, Weber, Stephanie, Narayan Dey, Partha, Chen, Changwei, Monteiro, Olivia, Buettner, Sven, Meyer, Katharina, Bano, Daniele, Radyushkin, Konstantin, Langston, Rosamund, Lambert, Jeremy J, Wanker, Erich, Methner, Axel, Krauss, Sybille, Schweiger, Susann, Stroh, Albrecht

“…Catching primal functional changes in early, 'very far from disease onset' (VFDO) stages of Huntington's disease is likely to be the key to a successful…”
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Exploring two-photon optogenetics beyond 1100 nm for specific and effective all-optical physiology by Fu, Ting, Arnoux, Isabelle, Döring, Jan, Backhaus, Hendrik, Watari, Hirofumi, Stasevicius, Ignas, Fan, Wei, Stroh, Albrecht

“…Two-photon (2-P) all-optical approaches combine in vivo 2-P calcium imaging and 2-P optogenetic modulations. Here, firstly, we combined in vivo juxtacellular…”
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Looping circuit: a novel mechanism for prolonged spontaneous [Ca2+]i increases in developing embryonic mouse brainstem by Watari, Hirofumi, Tose, Amanda J., Bosma, Martha M.

“…Key points Calcium concentration is kept at extremely low levels inside brain cells; each episode of calcium entry is cleared within seconds. Changes in…”
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Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release by Few, Alexandra P, Nanou, Evanthia, Watari, Hirofumi, Sullivan, Jane M, Scheuer, Todd, Catterall, William A

“…We have identified an asynchronously activated Ca2+ current through voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels, which conduct P/Q- and N-type Ca2+…”
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Effects of first trimester binge alcohol exposure on developing white matter in fetal sheep by WATARI, Hirofumi, BORN, Donald E, GLEASON, Christine A

“…Heavy prenatal alcohol exposure is associated with neurodevelopmental abnormalities. Neuropathologic and neuroimaging studies have shown a wide range of…”
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Modulation of CaV2.1 channels by Ca²⁺/calmodulin-dependent protein kinase II bound to the C-terminal domain by Jiang, Xin, Lautermilch, Nathan J, Watari, Hirofumi, Westenbroek, Ruth E, Scheuer, Todd, Catterall, William A

“…Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of synaptic responses in the postsynaptic density, but understanding of its mechanisms…”
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Functional states shape the spatiotemporal representation of local and cortex-wide neural activity in mouse sensory cortex by Schwalm, Miriam, Tabuena, Dennis R, Easton, Curtis, Richner, Thomas J, Mourad, Pierre, Watari, Hirofumi, Moody, William J, Stroh, Albrecht

“…The spatiotemporal representation of neural activity during rest and upon sensory stimulation in cortical areas is highly dynamic and may be predominantly…”
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Hyperpolarization of resting membrane potential causes retraction of spontaneous transients during mouse embryonic circuit development by Watari, Hirofumi, Tose, Amanda J., Bosma, Martha M.

“…Key points A wave of electrical activity occurs in the developing brain for a certain period of time before sensory, motor and cognitive functions mature. This…”
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A Novel Role for γ-Secretase: Selective Regulation of Spontaneous Neurotransmitter Release from Hippocampal Neurons by Pratt, Kara G., Zhu, Ping, Watari, Hirofumi, Cook, David G., Sullivan, Jane M.

“…With a multitude of substrates, γ-secretase is poised to control neuronal function through a variety of signaling pathways. Presenilin 1 (PS1) is an integral…”
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Asynchronous Ca2+current conducted by voltage-gated Ca2+(Cav)-2.1 and Cav2.2 channels and its implications for asynchronous neurotransmitter release by Few, Alexandra P., Nanou, Evanthia, Watari, Hirofumi, Sullivan, Jane M., Scheuer, Todd, Catterall, William A.

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Asynchronous Ca 2 + current conducted by voltage-gated Ca 2+ (Ca V )-2.1 and Ca V 2.2 channels and its implications for asynchronous neurotransmitter release by Few, Alexandra P., Nanou, Evanthia, Watari, Hirofumi, Sullivan, Jane M., Scheuer, Todd, Catterall, William A.

“…We have identified an asynchronously activated Ca 2+ current through voltage-gated Ca 2+ (Ca V )-2.1 and Ca V 2.2 channels, which conduct P/Q- and N-type Ca 2+…”
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Asynchronous Ca^sup 2+^ current conducted by voltage-gated Ca^sup 2+^ (Ca^sub V^)-2.1 and Ca^sub V^2.2 channels and its implications for asynchronous neurotransmitter release by Few, Alexandra P, Nanou, Evanthia, Watari, Hirofumi, Sullivan, Jane M, Scheuer, Todd, Catterall, William A

“…We have identified an asynchronously activated ... current through voltage-gated ... ... and ... channels, which conduct P/Q- and N-type ... currents that…”
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Stage-dependent regulation of intracellular calcium by spontaneous activity in developing brainstem by Watari, Hirofumi

“…Spontaneous activity supports developmental processes in many brain regions during embryogenesis, and the spatial extent and frequency of the spontaneous…”
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Hyperpolarization of resting membrane potential causes retraction of spontaneous Ca(i)²⁺ transients during mouse embryonic circuit development by Watari, Hirofumi, Tose, Amanda J, Bosma, Martha M

“…Abstract  Spontaneous activity supports developmental processes in many brain regions during embryogenesis, and the spatial extent and frequency of the…”
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Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes by Okamura, Yasushi, Nishino, Atsuo, Murata, Yoshimichi, Nakajo, Koichi, Iwasaki, Hirohide, Ohtsuka, Yukio, Tanaka-Kunishima, Motoko, Takahashi, Nobuyuki, Hara, Yuji, Yoshida, Takashi, Nishida, Motohiro, Okado, Haruo, Watari, Hirofumi, Meinertzhagen, Ian A, Satoh, Nori, Takahashi, Kunitaro, Satou, Yutaka, Okada, Yasunobu, Mori, Yasuo

“…1 Section of Developmental Neurophysiology, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki, Aichi 2 National…”
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Modulation of Ca V 2.1 channels by Ca 2+ /calmodulin-dependent protein kinase II bound to the C-terminal domain by Jiang, Xin, Lautermilch, Nathan J., Watari, Hirofumi, Westenbroek, Ruth E., Scheuer, Todd, Catterall, William A.

“…Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) is a key regulator of synaptic responses in the postsynaptic density, but understanding of its…”
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Modulation of${\rm Ca}_{{\rm V}}2.1$Channels by Ca²⁺/calmodulin-Dependent Protein Kinase II Bound to the C-Terminal Domain by Jiang, Xin, Lautermilch, Nathan J., Watari, Hirofumi, Westenbroek, Ruth E., Scheuer, Todd, Catterall, William A.

“…Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of synaptic responses in the postsynaptic density, but understanding of its mechanisms…”
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Modulation of Ca sub(V)2.1 channels by Ca super(2+)/calmodulin-dependent protein kinase II bound to the C-terminal domain by Jiang, Xin, Lautermilch, Nathan J, Watari, Hirofumi, Westenbroek, Ruth E, Scheuer, Todd, Catterall, William A

“…Ca super(2+)/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of synaptic responses in the postsynaptic density, but understanding of its…”
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Modulation of Ca^sub v^2.1 channels by Ca^sup 2+^/calmodulin-dependent protein kinase II bound to the C-terminal domain by Jiang, Xin, Lautermilch, Nathan J, Watari, Hirofumi, Westenbroek, Ruth E, Scheuer, Todd, Catterall, William A

“…Ca.../calmodulin-dependent protein kinase II (CaMKII) is a key regulator of synaptic responses in the postsynaptic density, but understanding of its mechanisms…”
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A novel role for {gamma}-secretase: selective regulation of spontaneous neurotransmitter release from hippocampal neurons by Pratt, Kara G, Zhu, Ping, Watari, Hirofumi, Cook, David G, Sullivan, Jane M

“…With a multitude of substrates, γ-secretase is poised to control neuronal function through a variety of signaling pathways. Presenilin 1 (PS1) is an integral…”
Get full text