Search Results - "Watanabe, Rira"

Improving conventional enhanced permeability and retention (EPR) effects; what is the appropriate target? by Kobayashi, Hisataka, Watanabe, Rira, Choyke, Peter L

“…Nano-sized therapeutic agents have several advantages over low molecular weight agents such as a larger loading capacity, the ability to protect the payload…”
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Cancer Drug Delivery: Considerations in the Rational Design of Nanosized Bioconjugates by Kobayashi, Hisataka, Turkbey, Baris, Watanabe, Rira, Choyke, Peter L

“…In order to efficiently deliver anticancer agents to tumors, biocompatible nanoparticles or bioconjugates, including antibody–drug conjugates (ADCs), have…”
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Near infrared photoimmunotherapy in the treatment of disseminated peritoneal ovarian cancer by Sato, Kazuhide, Hanaoka, Hirofumi, Watanabe, Rira, Nakajima, Takahito, Choyke, Peter L, Kobayashi, Hisataka

“…Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of intravenously injected antibodies for targeting tumors…”
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Photoimmunotherapy targeting prostate-specific membrane antigen: are antibody fragments as effective as antibodies? by Watanabe, Rira, Hanaoka, Hirofumi, Sato, Kazuhide, Nagaya, Tadanobu, Harada, Toshiko, Mitsunaga, Makoto, Kim, Insook, Paik, Chang H, Wu, Anna M, Choyke, Peter L, Kobayashi, Hisataka

“…Photoimmunotherapy is a highly cell-selective cancer therapy based on an armed antibody conjugate with a phthalocyanine-based photosensitizer, IR700…”
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Comparative effectiveness of light emitting diodes (LEDs) and Lasers in near infrared photoimmunotherapy by Sato, Kazuhide, Watanabe, Rira, Hanaoka, Hirofumi, Nakajima, Takahito, Choyke, Peter L, Kobayashi, Hisataka

“…Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with the toxicity induced…”
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Glypican‑3 Targeted Human Heavy Chain Antibody as a Drug Carrier for Hepatocellular Carcinoma Therapy by Hanaoka, Hirofumi, Nagaya, Tadanobu, Sato, Kazuhide, Nakamura, Yuko, Watanabe, Rira, Harada, Toshiko, Gao, Wei, Feng, Mingqian, Phung, Yen, Kim, Insook, Paik, Chang H, Choyke, Peter L, Ho, Mitchell, Kobayashi, Hisataka

“…Glypican-3 (GPC3) represents an attractive target for hepatocellular carcinoma (HCC) therapy because it is highly expressed in HCC but not in adult normal…”
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Photoimmunotherapy: Comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor by Sato, Kazuhide, Watanabe, Rira, Hanaoka, Hirofumi, Harada, Toshiko, Nakajima, Takahito, Kim, Insook, Paik, Chang H., Choyke, Peter L., Kobayashi, Hisataka

“…Photoimmunotherapy (PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with the toxicity induced by…”
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The effects of conjugate and light dose on photo-immunotherapy induced cytotoxicity by Nakajima, Takahito, Sato, Kazuhide, Hanaoka, Hirofumi, Watanabe, Rira, Harada, Toshiko, Choyke, Peter L, Kobayashi, Hisataka

“…Photoimmunotherapy (PIT) is a highly cell-selective cancer therapy, which employs monoclonal antibodies conjugated to a potent photosensitizer (mAb-IR700)…”
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Real-time monitoring of hemodynamic changes in tumor vessels during photoimmunotherapy using optical coherence tomography by Liang, Chia-Pin, Nakajima, Takahito, Watanabe, Rira, Sato, Kazuhide, Choyke, Peter L, Chen, Yu, Kobayashi, Hisataka

“…Photoimmunotherapy (PIT) is a cell-specific cancer therapy based on an armed antibody conjugate that induces rapid and highly selective cancer cell necrosis…”
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Minibody-Indocyanine Green Based Activatable Optical Imaging Probes: The Role of Short Polyethylene Glycol Linkers by Watanabe, Rira, Sato, Kazuhide, Hanaoka, Hirofumi, Harada, Toshiko, Nakajima, Takahito, Kim, Insook, Paik, Chang H, Wu, Anna M, Choyke, Peter L, Kobayashi, Hisataka

“…Minibodies show rapider blood clearance than IgGs due to smaller size that improves target-to-background ratio (TBR) in in vivo imaging. Additionally, the…”
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Design of colon specific delivery system for mice by visualizing the gastrointestinal localization using in vivo imaging technology by Iwasaki, Masaru, Matsumoto, Wakaba, Kanda, Mayumi, Suzuki, Norio, Kawabata, Yuki, Watanabe, Rira, Yabe, Yoshiyuki, Kobayashi, Hideo, Takahashi, Masayuki

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Fluorescence‐lifetime molecular imaging can detect invisible peritoneal ovarian tumors in bloody ascites by Nakajima, Takahito, Sano, Kohei, Sato, Kazuhide, Watanabe, Rira, Harada, Toshiko, Hanaoka, Hirofumi, Choyke, Peter L., Kobayashi, Hisataka

“…Blood contamination, such as bloody ascites or hemorrhages during surgery, is a potential hazard for clinical application of fluorescence imaging. In order to…”
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Characterization of Tumor Imaging with Microbubble-Based Ultrasound Contrast Agent, Sonazoid, in Rabbit Liver by Watanabe, Rira, Matsumura, Manabu, Chen, Chun-Jen, Kaneda, Yuki, Fujimaki, Masayoshi

“…In order to investigate improvement of hepatic tumor detectability by Sonazoid with phase inversion imaging, the contrast effects on the liver of metastatic…”
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Gray-Scale Liver Enhancement with Sonazoid (NC100100), a Novel Ultrasound Contrast Agent; Detection of Hepatic Tumors in a Rabbit Model by Watanabe, Rira, Matsumura, Manabu, Chen, Chun-Jen, Kaneda, Yuki, Ishihara, Masanao, Fujimaki, Masayoshi

“…The liver contrast effects of Sonazoid in two ultrasonographic imaging modes, gray-scale conventional and harmonic, were examined as a time-related study in…”
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Acoustic Cluster Therapy (ACT) – A novel concept for ultrasound mediated, targeted drug delivery by Sontum, Per, Kvåle, Svein, Healey, Andrew John, Skurtveit, Roald, Watanabe, Rira, Matsumura, Manabu, Østensen, Jonny

“…[Display omitted] A novel approach for ultrasound (US) mediated drug delivery – Acoustic Cluster Therapy (ACT) – is proposed, and basic characteristics of the…”
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Contrast-Enhanced Ultrasound with Perflubutane in the Assessment of Anti-Angiogenic Effects: Early Prediction of the Anticancer Activity of Bevacizumab in a Mouse Xenografted Model by Watanabe, Rira, Munemasa, Toshiko, Matsumura, Manabu

“…Abstract To investigate the feasibility of contrast-enhanced ultrasound (CEUS) with perflubutane for evaluating anti-angiogenic effects, we assessed the…”
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Mechanism of Hepatic Parenchyma-Specific Contrast of Microbubble-Based Contrast Agent for Ultrasonography: Microscopic Studies in Rat Liver by Watanabe, Rira, Matsumura, Manabu, Munemasa, Toshiko, Fujimaki, Masayoshi, Suematsu, Makoto

“…OBJECTIVE:The objective of this study was to elucidate the mechanism of hepatic parenchyma-specific contrast of Sonazoid (microbubble contrast agent) using…”
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Activatable Organic Near-Infrared Fluorescent Probes Based on a Bacteriochlorin Platform: Synthesis and Multicolor in Vivo Imaging with a Single Excitation by Harada, Toshiko, Sano, Kohei, Sato, Kazuhide, Watanabe, Rira, Yu, Zhanqian, Hanaoka, Hirofumi, Nakajima, Takahito, Choyke, Peter L, Ptaszek, Marcin, Kobayashi, Hisataka

“…Near infrared (NIR) fluorescent probes are ideal for in vivo imaging because they offer deeper tissue penetration and lower background autofluorescence…”
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Photoimmunotherapy of hepatocellular carcinoma-targeting Glypican-3 combined with nanosized albumin-bound paclitaxel by Hanaoka, Hirofumi, Nakajima, Takahito, Sato, Kazuhide, Watanabe, Rira, Phung, Yen, Gao, Wei, Harada, Toshiko, Kim, Insook, Paik, Chang H, Choyke, Peter L, Ho, Mitchell, Kobayashi, Hisataka

“…Effectiveness of Glypican-3 (GPC3)-targeted photoimmunotherapy (PIT) combined with the nanoparticle albumin-bound paclitaxel (nab-paclitaxel) for…”
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Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development: CINP/JSNP Working Group Report by Suhara, Tetsuya, Chaki, Shigeyuki, Kimura, Haruhide, Furusawa, Makoto, Matsumoto, Mitsuyuki, Ogura, Hiroo, Negishi, Takaaki, Saijo, Takeaki, Higuchi, Makoto, Omura, Tomohiro, Watanabe, Rira, Miyoshi, Sosuke, Nakatani, Noriaki, Yamamoto, Noboru, Liou, Shyh-Yuh, Takado, Yuhei, Maeda, Jun, Okamoto, Yasumasa, Okubo, Yoshiaki, Yamada, Makiko, Ito, Hiroshi, Walton, Noah M., Yamawaki, Shigeto

“…Abstract Despite large unmet medical needs in the field for several decades, CNS drug discovery and development has been largely unsuccessful. Biomarkers,…”
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