Search Results - "Watała, Cezary"
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Single-Nucleotide Polymorphisms in Genes Maintaining the Stability of Mitochondrial DNA Affect the Occurrence, Onset, Severity and Treatment of Major Depressive Disorder
Published in International journal of molecular sciences (01-10-2023)“…One of the key features of major depressive disorder (MDD, depression) is increased oxidative stress manifested by elevated levels of mtROS, a hallmark of…”
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The Association of Oxidative and Antioxidant Potential with Cardiometabolic Risk Profile in the Group of 60- to 65-Year-Old Seniors from Central Poland
Published in Antioxidants (27-05-2022)“…Pathogenesis of cardiovascular diseases is caused by, inter alia, oxidative stress. On the other hand, cardiovascular risk factors may cause redox imbalance…”
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3
Modifications of disulfide bonds in breast cancer cell migration and invasiveness
Published in American journal of cancer research (01-01-2019)“…Cancer metastasis involves the adhesion of cancer cells to the endothelium. This process can be mediated by integrins which are surface receptors responsible…”
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Effect of acetylsalicylic acid intake on platelet derived microvesicles in healthy subjects
Published in Platelets (Edinburgh) (17-02-2020)“…Platelet-derived microvesicles (pMVs) are released from platelets in physiological and pathological conditions and exhibit a wide range of prothrombotic,…”
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Hyaluronic Acid-Based Nanocapsules as Efficient Delivery Systems of Garlic Oil Active Components with Anticancer Activity
Published in Nanomaterials (Basel, Switzerland) (20-05-2021)“…Diallyl disulfide (DADS) and diallyl trisulfide (DATS) are garlic oil compounds exhibiting beneficial healthy properties including anticancer action. However,…”
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What is the most important determinant of cardiometabolic risk in 60–65-year-old subjects: physical activity-related behaviours, overall energy expenditure or occupational status? A cross-sectional study in three populations with different employment status in Poland
Published in BMJ open (30-07-2019)“…ObjectivesThe aim of the study was to determine whether cardiovascular risk factors may differ according to occupational status and whether physical activity…”
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An inverse relationship between plasma glutathione concentration and fasting glycemia in patients with coronary artery disease and concomitant type 2 diabetes: A pilot study
Published in Advances in clinical and experimental medicine : official organ Wroclaw Medical University (01-12-2017)“…There have been occasional reports indicating that plasma concentrations of reduced glutathione (GSH) may be associated in some way with blood glucose. This…”
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Coronary Artery Disease Is Related to Methylation Disorders Caused by the c.1286A>C MTHFR Polymorphism and to Low Serum 5-MTHF and Folic Acid Concentrations—Preliminary Results
Published in Reports (MDPI) (01-01-2024)“…Background: Single nucleotide polymorphisms in gene encoding is the key enzyme in the folates pathway, methyltetrahydrofolate reductase (MTHFR), which causes…”
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Regulation of cell function by isoforms of C-reactive protein: a comparative analysis
Published in Acta biochimica polonica (01-01-2009)“…Despite the emerging evidence suggesting a proatherogenic role of C-reactive protein (CRP) in atherosclerosis, the contribution of CRP in pathogenesis of…”
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Taxon analysis of seed plants used in studies of blood platelet function
Published in Postȩpy higieny i medycyny doświadczalnej (28-11-2013)“…The characterization of isolated polyphenolic compounds present in the diet--especially in the context of their therapeutic effect (for instance their…”
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Blood Platelets as an Important but Underrated Circulating Source of TGFβ
Published in International journal of molecular sciences (26-04-2021)“…When treating diseases related primarily to tissue remodeling and fibrosis, it is desirable to regulate TGFβ concentration and modulate its biological effects…”
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Can the antiplatelet effects of cangrelor be reliably studied in mice under in vivo and in vitro conditions using flow cytometry?
Published in Pharmacological reports (2013)“…The effects of blood platelet inhibitors are often not quite equivalent under in vivo and in vitro conditions. Amongst various models of human pathology using…”
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The Multiple Faces of C-Reactive Protein-Physiological and Pathophysiological Implications in Cardiovascular Disease
Published in Molecules (Basel, Switzerland) (30-05-2019)“…C-reactive protein (CRP) is an intriguing protein which plays a variety of roles in either physiological or pathophysiological states. For years it has been…”
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Anti-diabetic effects of 1-methylnicotinamide (MNA) in streptozocin-induced diabetes in rats
Published in Pharmacological reports (01-01-2009)“…1-Methylnicotinamide (MNA), a major endogenous metabolite of nicotinamide, possesses anti-thrombotic and anti-inflammatory activity, and reverses endothelial…”
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Estradiol as the Trigger of Sirtuin-1-Dependent Cell Signaling with a Potential Utility in Anti-Aging Therapies
Published in International journal of molecular sciences (01-09-2023)“…Aging entails the inevitable loss of the structural and functional integrity of cells and tissues during the lifetime. It is a highly hormone-dependent…”
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Changes in response to clopidogrel therapy in patients after percutaneous coronary interventions as assessed by different platelet function tests
Published in Polskie archiwum medycyny wewne̦trznej (18-08-2016)“…INTRODUCTION Recently, the responder status to clopidogrel therapy has been observed to change over time. OBJECTIVES The aim of the study was to investigate…”
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Mitochondrial functioning abnormalities observed in blood platelets of chronic smoke-exposed guinea pigs - a pilot study
Published in International journal of chronic obstructive pulmonary disease (01-01-2018)“…COPD represents a major global health issue, which is often accompanied by cardiovascular diseases. A considerable body of evidence suggests that…”
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Modified C-reactive protein interacts with platelet glycoprotein Ibα
Published in Pharmacological reports (2011)“…Herein, we investigated the possible mechanisms by which recombinant modified CRP (mrCRP) modulates blood platelet function. Modified CRP could activate blood…”
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1-Methylnicotinamide (MNA) prevents endothelial dysfunction in hypertriglyceridemic and diabetic rats
Published in Pharmacological reports (01-01-2008)“…For many years, 1-methylnicotinamide (MNA), a primary metabolite of nicotinamide, has been considered inactive. Recently however, it has been discovered that…”
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Sample size and significance - somewhere between statistical power and judgment prostration
Published in Archives of medical science (01-03-2007)“…When performing scientific research we are so "embraced" to use the tool of inductive logic in our reasoning that we often express more generalized opinions on…”
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