Anti-inflammatory and anti-allergic activities of Pentaherb formula, Moutan Cortex (Danpi) and gallic acid

Anti-inflammatory and anti-allergic activities of Pentaherb formula, Moutan Cortex (Danpi) and gallic acid

Pentaherb formula (PHF) has been proven to improve the quality of life of children with atopic dermatitis without side effects. The aim of this study was to elucidate the potential anti-inflammatory and anti-allergic activities of PHF, Moutan Cortex (Danpi/DP) and gallic acid (GA) using human basoph...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Vol. 18; no. 3; pp. 2483 - 2500
Main Authors: Liu, Kelly Y P, Hu, Shuiqing, Chan, Ben C L, Wat, Elaine C L, Lau, Clara B S, Hon, Kam L, Fung, Kwok P, Leung, Ping C, Hui, Patrick C L, Lam, Christopher W K, Wong, Chun K
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 25-02-2013
MDPI
Subjects:
Acids
anti-allergic
Anti-Allergic Agents - pharmacology
anti-inflammatory
Anti-Inflammatory Agents - pharmacology
Asthma
Basophils - drug effects
Basophils - metabolism
Cell Adhesion Molecules - metabolism
Cell Line
Chemokines
Chemokines - biosynthesis
Chinese medicine
Cytokines
Dermatitis
Dexamethasone - pharmacology
Drugs, Chinese Herbal - pharmacology
gallic acid
Gallic Acid - pharmacology
Hay fever
Humans
Inflammation
Inflammatory diseases
Interleukin-33
Interleukin-6 - biosynthesis
Interleukins - pharmacology
JNK Mitogen-Activated Protein Kinases - metabolism
Kinases
Leukocytes
moutan cortex
p38 Mitogen-Activated Protein Kinases - metabolism
Paeonia
pentaherb formula
Phosphorylation - drug effects
Quality of life
Rhinitis
Skin diseases
Hong Kong China
United Kingdom > UK
China
Wales
Macao
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Summary:Pentaherb formula (PHF) has been proven to improve the quality of life of children with atopic dermatitis without side effects. The aim of this study was to elucidate the potential anti-inflammatory and anti-allergic activities of PHF, Moutan Cortex (Danpi/DP) and gallic acid (GA) using human basophils (KU812 cells), which are crucial effector cells in allergic inflammation. PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p < 0.05). With the combined use of dexamethasone (0.01 μg/mL) and GA (10 μg/mL), the suppression of ICAM-1 expression and CCL5 and IL-6 release of IL-33-activated KU812 cells were significantly greater than the use of GA alone (all p < 0.05). The suppression of the IL-33-induced activation of intracellular signalling molecules p38 mitogen activated protein kinase, nuclear factor-kB and c-Jun amino-terminal kinase in GA-treated KU812 cells could be the underlying mechanism for the suppression on ICAM-1, chemokines and cytokines. The combined use of dexamethasone with the natural products PHF or DP or GA might therefore enhance the development of a novel therapeutic modality for allergic inflammatory diseases with high potency and fewer side effects.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules18032483