Search Results - "Wasterlain, Claude"

Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus by Naylor, David E, Liu, Hantao, Niquet, Jerome, Wasterlain, Claude G

“…Abstract After 1 h of lithium-pilocarpine status epilepticus (SE), immunocytochemical labeling of NMDA receptor NR1 subunits reveals relocation of subunits…”
Get full text

Phenobarbital and midazolam increase neonatal seizure‐associated neuronal injury by Torolira, Daniel, Suchomelova, Lucie, Wasterlain, Claude G., Niquet, Jerome

“…Status epilepticus is common in neonates and infants, and is associated with neuronal injury and adverse developmental outcomes. γ‐Aminobutyric acidergic…”
Get full text

Midazolam–ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits by Niquet, Jerome, Baldwin, Roger, Norman, Keith, Suchomelova, Lucie, Lumley, Lucille, Wasterlain, Claude G.

“…Summary Objective Pharmacoresistance remains an unsolved therapeutic challenge in status epilepticus (SE) and in cholinergic SE induced by nerve agent…”
Get full text

Benzodiazepine-refractory status epilepticus: pathophysiology and principles of treatment by Niquet, Jerome, Baldwin, Roger, Suchomelova, Lucie, Lumley, Lucille, Naylor, David, Eavey, Roland, Wasterlain, Claude G.

“…Cholinergic status epilepticus (CSE) quickly becomes self‐sustaining, independent of its initial trigger, and resistant to benzodiazepines and other…”
Get full text

Treatment of experimental status epilepticus with synergistic drug combinations by Niquet, Jerome, Baldwin, Roger, Suchomelova, Lucie, Lumley, Lucille, Eavey, Roland, Wasterlain, Claude G.

“…Summary During status epilepticus (SE), synaptic γ‐aminobutyric acid A receptors (GABAARs) become internalized and inactive, whereas spare N‐methyl‐d‐aspartate…”
Get full text

Trafficking of GABAA Receptors, Loss of Inhibition, and a Mechanism for Pharmacoresistance in Status Epilepticus by Naylor, David E, Liu, Hantao, Wasterlain, Claude G

“…During status epilepticus (SE), GABAergic mechanisms fail and seizures become self-sustaining and pharmacoresistant. During lithiumpilocarpine-induced SE, our…”
Get full text

Simultaneous triple therapy for the treatment of status epilepticus by Niquet, Jerome, Baldwin, Roger, Norman, Keith, Suchomelova, Lucie, Lumley, Lucille, Wasterlain, Claude G

“…Abstract Early maladaptive internalization of synaptic GABAA receptors (GABAA R) and externalization of NMDA receptors (NMDAR) may explain the time-dependent…”
Get full text

Rational polytherapy in the treatment of cholinergic seizures by Niquet, Jerome, Lumley, Lucille, Baldwin, Roger, Rossetti, Franco, Suchomelova, Lucie, Naylor, David, Estrada, Ireri Betsabe Franco, Schultz, Mark, Furtado, Marcio de Araujo, Wasterlain, Claude G.

“…The initiation and maintenance phases of cholinergic status epilepticus (SE) are associated with maladaptive trafficking of synaptic GABAA and glutamate…”
Get full text

Status epilepticus: pathophysiology and management in adults by Chen, James W Y, Wasterlain, Claude G

“…As in Clark and Prout's classic work, we identify three phases of generalised convulsive status epilepticus, which we call impending, established, and subtle…”
Get more information

Evaluation of Midazolam-Ketamine-Allopregnanolone Combination Therapy against Cholinergic-Induced Status Epilepticus in Rats by Nguyen, Donna A, Stone, Michael F, Schultz, Caroline R, de Araujo Furtado, Marcio, Niquet, Jerome, Wasterlain, Claude G, Lumley, Lucille A

“…Status epilepticus (SE) is a life-threatening development of self-sustaining seizures that becomes resistant to benzodiazepines when treatment is delayed…”
Get more information

Widespread neuronal injury in a model of cholinergic status epilepticus in postnatal day 7 rat pups by Torolira, Daniel, Suchomelova, Lucie, Wasterlain, Claude G, Niquet, Jerome

“…Highlights • Cholinergic status epilepticus was induced with high-dose lithium and pilocarpine in postnatal day 7 rat pups. • EEGs showed continuous polyspikes…”
Get full text

Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus by Naylor, David E, Liu, Hantao, Wasterlain, Claude G

“…During status epilepticus (SE), GABAergic mechanisms fail and seizures become self-sustaining and pharmacoresistant. During lithiumpilocarpine-induced SE, our…”
Get full text

Efficacy of Lacosamide and Rufinamide as Adjuncts to Midazolam-Ketamine Treatment Against Cholinergic-Induced Status Epilepticus in Rats by Lumley, Lucille A, Nguyen, Donna A, de Araujo Furtado, Marcio, Niquet, Jerome, Linz, Emily O, Schultz, Caroline R, Stone, Michael F, Wasterlain, Claude G

“…Benzodiazepine pharmacoresistance develops when treatment of status epilepticus (SE) is delayed. This response may result from gamma-aminobutyric acid A…”
Get more information

Early polytherapy for benzodiazepine-refractory status epilepticus by Niquet, Jerome, Lumley, Lucille, Baldwin, Roger, Rossetti, Franco, Schultz, Mark, de Araujo Furtado, Marcio, Suchomelova, Lucie, Naylor, David, Franco-Estrada, Ireri, Wasterlain, Claude G.

“…The transition from single seizures to status epilepticus (SE) is associated with malaptive trafficking of synaptic gamma-aminobutyric acid (GABAA) and…”
Get full text

Trafficking of NMDA receptors during status epilepticus: Therapeutic implications by Wasterlain, Claude G., Naylor, David E., Liu, Hantao, Niquet, Jerome, Baldwin, Roger

“…Summary We used two models of status epilepticus (SE) to study trafficking of N‐methyl‐d‐aspartate (NMDA) receptors. SE is associated with increased surface…”
Get full text

Deep hypothermia for the treatment of refractory status epilepticus by Niquet, Jerome, Baldwin, Roger, Gezalian, Michael, Wasterlain, Claude G

“…Abstract In a rat model of status epilepticus (SE) induced by lithium and pilocarpine and refractory to midazolam, deep hypothermia (20 °C for 30 min) reduced…”
Get full text

Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs by Wasterlain, Claude G., Chen, James W. Y.

“…Summary We review recent advances in our understanding and treatment of status epilepticus (SE). Repeated seizures cause an internalization of γ‐aminobutyric…”
Get full text

Rational polytherapy in the treatment of acute seizures and status epilepticus by Wasterlain, Claude G., Baldwin, Roger, Naylor, David E., Thompson, Kerry W., Suchomelova, Lucie, Niquet, Jerome

“…Summary We used a model of severe cholinergic status epilepticus (SE) to study polytherapy aimed at reversing the effects of seizure‐induced loss of synaptic…”
Get full text

Interictal aggression in rats with chronic seizures after an early life episode of status epilepticus by Suchomelova, Lucie, Thompson, Kerry W., Baldwin, Roger A., Niquet, Jerome, Wasterlain, Claude G.

“…Objective In spite of anecdotal reports describing an association between chronic epilepsy and interictal aggressiveness, and of a few studies suggesting that…”
Get full text

The acute and chronic effects of the novel anticonvulsant lacosamide in an experimental model of status epilepticus by Wasterlain, Claude G, Stöhr, Thomas, Matagne, Alain

“…Summary The effective management of status epilepticus (SE) continues to be a therapeutic challenge. The aim of this study was to investigate the efficacy of…”
Get full text