Search Results - "Wassouf, Zinah"

The Role of Alpha-Synuclein and Other Parkinson's Genes in Neurodevelopmental and Neurodegenerative Disorders by Morato Torres, C Alejandra, Wassouf, Zinah, Zafar, Faria, Sastre, Danuta, Outeiro, Tiago Fleming, Schüle, Birgitt

“…Neurodevelopmental and late-onset neurodegenerative disorders present as separate entities that are clinically and neuropathologically quite distinct. However,…”
Get full text

Distinct impacts of alpha-synuclein overexpression on the hippocampal epigenome of mice in standard and enriched environments by Schaffner, Samantha L., Wassouf, Zinah, Hentrich, Thomas, Nuesch-Germano, Melanie, Kobor, Michael S., Schulze-Hentrich, Julia M.

“…Elevated alpha-synuclein (SNCA) gene expression is associated with transcriptional deregulation and increased risk of Parkinson's disease, which may be…”
Get full text

Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways by Schaffner, Samantha L, Wassouf, Zinah, Lazaro, Diana F, Xylaki, Mary, Gladish, Nicole, Lin, David T S, MacIsaac, Julia, Ramadori, Katia, Hentrich, Thomas, Schulze-Hentrich, Julia M, Outeiro, Tiago F, Kobor, Michael S

“…Parkinson's disease (PD) is a neurological disorder with complex interindividual etiology that is becoming increasingly prevalent worldwide. Elevated…”
Get full text

Unraveling Molecular Mechanisms of THAP1 Missense Mutations in DYT6 Dystonia by Cheng, Fubo, Walter, Michael, Wassouf, Zinah, Hentrich, Thomas, Casadei, Nicolas, Schulze-Hentrich, Julia, Barbuti, Peter, Krueger, Rejko, Riess, Olaf, Grundmann-Hauser, Kathrin, Ott, Thomas

“…Mutations in THAP1 (THAP domain-containing apoptosis-associated protein 1) are responsible for DYT6 dystonia. Until now, more than eighty different mutations…”
Get full text

Impaired dopamine- and adenosine-mediated signaling and plasticity in a novel rodent model for DYT25 dystonia by Yu-Taeger, Libo, Ott, Thomas, Bonsi, Paola, Tomczak, Celina, Wassouf, Zinah, Martella, Giuseppina, Sciamanna, Giuseppe, Imbriani, Paola, Ponterio, Giulia, Tassone, Annalisa, Schulze-Hentrich, Julia M., Goodchild, Rose, Riess, Olaf, Pisani, Antonio, Grundmann-Hauser, Kathrin, Nguyen, Huu Phuc

“…Dystonia is a neurological movement disorder characterized by sustained or intermittent involuntary muscle contractions. Loss-of-function mutations in the GNAL…”
Get full text

Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson's disease patients by Hentrich, Thomas, Wassouf, Zinah, Ehrhardt, Christine, Haas, Eva, Mills, James D, Aronica, Eleonora, Outeiro, Tiago Fleming, Hübener-Schmid, Jeannette, Riess, Olaf, Casadei, Nicolas, Schulze-Hentrich, Julia M

“…Parkinson's disease (PD) is an age-dependent neurodegenerative disorder. Besides characteristic motor symptoms, patients suffer from cognitive impairments…”
Get full text

Enriched Environmental Conditions Modify the Gut Microbiome Composition and Fecal Markers of Inflammation in Parkinson’s Disease by Singh, Yogesh, El-Hadidi, Mohamed, Admard, Jakob, Wassouf, Zinah, Schulze-Hentrich, Julia M., Kohlhofer, Ursula, Quintanilla-Martinez, Leticia, Huson, Daniel, Riess, Olaf, Casadei, Nicolas

“…Recent findings suggest an implication of the gut microbiome in Parkinson’s disease (PD) patients. PD onset and progression has also been linked with various…”
Get full text

Environmental Enrichment Prevents Transcriptional Disturbances Induced by Alpha-Synuclein Overexpression by Wassouf, Zinah, Hentrich, Thomas, Samer, Sebastian, Rotermund, Carola, Kahle, Philipp J, Ehrlich, Ingrid, Riess, Olaf, Casadei, Nicolas, Schulze-Hentrich, Julia M

“…Onset and progression of neurodegenerative disorders, including synucleinopathies such as Parkinson's disease, have been associated with various environmental…”
Get full text

Distinct Stress Response and Altered Striatal Transcriptome in Alpha-Synuclein Overexpressing Mice by Wassouf, Zinah, Hentrich, Thomas, Casadei, Nicolas, Jaumann, Mirko, Knipper, Marlies, Riess, Olaf, Schulze-Hentrich, Julia M

“…Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor symptoms and a plethora of non-motor and neuropsychiatric features that…”
Get full text

Alpha‐synuclein at the nexus of genes and environment: the impact of environmental enrichment and stress on brain health and disease by Wassouf, Zinah, Schulze‐Hentrich, Julia M.

“…Accumulation of alpha‐synuclein protein aggregates is the hallmark neuropathologic feature of synucleinopathies such as Parkinson’s disease. Rare point…”
Get full text

α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses by Sugeno, Naoto, Jäckel, Sandra, Voigt, Aaron, Wassouf, Zinah, Schulze-Hentrich, Julia, Kahle, Philipp J.

“…α-Synuclein (αS) is a protein linked to Parkinson’s disease (PD) and related neurodegenerative disorders. It is mostly localized within synapses, but αS has…”
Get full text

B05 Environment-driven influences and neuroprotection in the BACHD RAT model for huntington disease by Wassouf, Zinah, Hentrich, Thomas, Novati, Arianna, Riess, Olaf, Nguyen, Huu Phuc, Schulze-Hentrich, Julia M

“…BackgroundHuntington disease (HD) is a progressive neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene. Despite being a monogenic…”
Get full text

SNCA overexpression disturbs hippocampal gene expression trajectories in midlife by Hentrich, Thomas, Wassouf, Zinah, Riess, Olaf, Schulze-Hentrich, Julia M

“…Synucleinopathies like Parkinson's disease and dementia with Lewy bodies originate from a complex and still largely enigmatic interplay of genetic…”
Get full text

Pathophysiological interplay between O-GlcNAc transferase and the Machado–Joseph disease protein ataxin-3 by Sena, Priscila Pereira, Weber, Jonasz J., Watchon, Maxinne, Robinson, Katherine J., Wassouf, Zinah, Hauser, Stefan, Helm, Jacob, Abeditashi, Mahkameh, Schmidt, Jana, Hübener-Schmid, Jeannette, Schöls, Ludger, Laird, Angela S., Riess, Olaf, Schmidt, Thorsten

“…Aberrant O-GlcNAcylation, a protein posttranslational modification defined by the O-linked attachment of the monosaccharide N-acetylglucosamine (O-GlcNAc), has…”
Get full text

B04 Environment-dependent modulation of striatal gene expression in the BACHD RAT model by Novati, Arianna, Hentrich, Thomas, Wassouf, Zinah, Weber, Jonasz, Yu-Taeger, Libo, Déglon, Nicole, Hoa Huu Phuc Nguyen, Schulze-Hentrich, Julia

“…BackgroundHuntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in exon 1 of the huntingtin (HTT)…”
Get full text

miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy by Xylaki, Mary, Paiva, Isabel, Al-Azzani, Mohammed, Gerhardt, Ellen, Jain, Gaurav, Islam, Md Rezaul, Vasili, Eftychia, Wassouf, Zinah, Schulze-Hentrich, Julia M., Fischer, André, Outeiro, Tiago Fleming

“…Background: Synucleinopathies are disorders characterized by the abnormal accumulation of α-synuclein (aSyn). Synaptic compromise is observed in…”
Get full text

Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease by Novati, Arianna, Hentrich, Thomas, Wassouf, Zinah, Weber, Jonasz J., Yu-Taeger, Libo, Déglon, Nicole, Nguyen, Huu Phuc, Schulze-Hentrich, Julia M.

“…Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin ( HTT ) gene which results in progressive…”
Get full text

[alpha]-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses by Sugeno, Naoto, Jäckel, Sandra, Voigt, Aaron, Wassouf, Zinah, Schulze-hentrich, Julia, Kahle, Philipp J

“…α-Synuclein (αS) is a protein linked to Parkinson's disease (PD) and related neurodegenerative disorders. It is mostly localized within synapses, but αS has…”
Get full text