Search Results - "Wassmer, Samuel C."

Harnessing the Potential of miRNAs in Malaria Diagnostic and Prevention by Gupta, Himanshu, Wassmer, Samuel C

“…Despite encouraging progress over the past decade, malaria remains a major global health challenge. Its severe form accounts for the majority of…”
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Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach by Wassmer, Samuel C, Taylor, Terrie E, Rathod, Pradipsinh K, Mishra, Saroj K, Mohanty, Sanjib, Arevalo-Herrera, Myriam, Duraisingh, Manoj T, Smith, Joseph D

“…More than a century after the discovery of Plasmodium spp. parasites, the pathogenesis of severe malaria is still not well understood. The majority of malaria…”
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Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children by Moxon, Christopher A., Wassmer, Samuel C., Milner, Danny A., Chisala, Ngawina V., Taylor, Terrie E., Seydel, Karl B., Molyneux, Malcolm E., Faragher, Brian, Esmon, Charles T., Downey, Colin, Toh, Cheng-Hock, Craig, Alister G., Heyderman, Robert S.

“…Cerebral malaria (CM) is a major cause of mortality in African children and the mechanisms underlying its development, namely how malaria-infected erythrocytes…”
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Malaria inflammation by xanthine oxidase‐produced reactive oxygen species by Ty, Maureen C, Zuniga, Marisol, Götz, Anton, Kayal, Sriti, Sahu, Praveen K, Mohanty, Akshaya, Mohanty, Sanjib, Wassmer, Samuel C, Rodriguez, Ana

“…Malaria is a highly inflammatory disease caused by Plasmodium infection of host erythrocytes. However, the parasite does not induce inflammatory cytokine…”
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PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury by Du, Xinyue, Ren, Baiyang, Li, Chang, Li, Qi, Kan, Shuo, Wang, Xin, Bai, Wenjuan, Wu, Chenyun, Kassegne, Kokouvi, Yan, Huibo, Niu, Xiaoyin, Yan, Min, Xu, Wenyue, Wassmer, Samuel C., Wang, Jing, Chen, Guangjie, Wang, Zhaojun

“…Excessive host immune responses contribute to severe malaria with high mortality. Here, we show that PRL2 in innate immune cells is highly related to…”
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Diagnosis of cerebral malaria: Tools to reduce Plasmodium falciparum associated mortality by Muppidi, Pranavi, Wright, Emily, Wassmer, Samuel C, Gupta, Himanshu

“…Cerebral malaria (CM) is a major cause of mortality in Plasmodium falciparum (Pf) infection and is associated with the sequestration of parasitised…”
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Editorial: Platelets as Players in Neuropathologies: Novel Diagnostic and Therapeutic Targets by Wassmer, Samuel C, Humpel, Christian, Orian, Jacqueline M

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Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection by Hochman, Sarah E, Madaline, Theresa F, Wassmer, Samuel C, Mbale, Emmie, Choi, Namjong, Seydel, Karl B, Whitten, Richard O, Varughese, Julie, Grau, Georges E R, Kamiza, Steve, Molyneux, Malcolm E, Taylor, Terrie E, Lee, Sunhee, Milner, Jr, Danny A, Kim, Kami

“…Cerebral malaria (CM) is a major contributor to malaria deaths, but its pathophysiology is not well understood. While sequestration of parasitized erythrocytes…”
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Plasma levels of hsa‐miR‐3158‐3p microRNA on admission correlate with MRI findings and predict outcome in cerebral malaria by Gupta, Himanshu, Sahu, Praveen K., Pattnaik, Rajyabardhan, Mohanty, Anita, Majhi, Megharay, Mohanty, Akshaya K., Pirpamer, Lukas, Hoffmann, Angelika, Mohanty, Sanjib, Wassmer, Samuel C.

“…Severe Plasmodium falciparum malaria (SM) remains a leading cause of mortality worldwide and is characterized by a combination of unregulated inflammatory…”
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Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India by Anvikar, Anupkumar R., van Eijk, Anna Maria, Shah, Asha, Upadhyay, Kamlesh J., Sullivan, Steven A., Patel, Ankita J., Joshi, Jaykumar M., Tyagi, Suchi, Singh, Ranvir, Carlton, Jane M., Gupta, Himanshu, Wassmer, Samuel C.

“…The mounting evidence supporting the capacity of Plasmodium vivax to cause severe disease has prompted the need for a better characterization of the resulting…”
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Magnetic Resonance Imaging of Cerebral Malaria Patients Reveals Distinct Pathogenetic Processes in Different Parts of the Brain by Mohanty, Sanjib, Benjamin, Laura A, Majhi, Megharay, Panda, Premanand, Kampondeni, Sam, Sahu, Praveen K, Mohanty, Akshaya, Mahanta, Kishore C, Pattnaik, Rajyabardhan, Mohanty, Rashmi R, Joshi, Sonia, Mohanty, Anita, Turnbull, Ian W, Dondorp, Arjen M, Taylor, Terrie E, Wassmer, Samuel C

“…The mechanisms underlying the rapidly reversible brain swelling described in patients with cerebral malaria (CM) are unknown. Using a 1.5-Tesla (T) magnetic…”
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Characterization of Lymphocyte Subsets in Lymph Node and Spleen Sections in Fatal Pediatric Malaria by Mandala, Wilson L, Ward, Steve, Taylor, Terrie E, Wassmer, Samuel C

“…Secondary lymphoid tissues play a major role in the human immune response to infection. Previous studies have shown that acute falciparum malaria is associated…”
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Platelets Potentiate Brain Endothelial Alterations Induced by Plasmodium falciparum by Wassmer, Samuel C, Combes, Valéry, Candal, Francisco J, Juhan-Vague, Irène, Grau, Georges E

“…Brain lesions of cerebral malaria (CM) are characterized by a sequestration of Plasmodium falciparum-parasitized red blood cells (PRBC) and platelets within…”
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Cell vesiculation and immunopathology: implications in cerebral malaria by Coltel, Nicolas, Combes, Valéry, Wassmer, Samuel C., Chimini, Giovanna, Grau, Georges E.

“…Microparticles are plasma membrane fragments that are generated and released under physiological conditions. They are also released when tissue and/or systemic…”
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The kidney–brain pathogenic axis in severe falciparum malaria by Conroy, Andrea L., Datta, Dibyadyuti, Hoffmann, Angelika, Wassmer, Samuel C.

“…New evidence highlights a potential role for kidney injury in the development of neurocognitive sequelae in children with severe falciparum malaria.In…”
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The brain–kidney–retinal axis in severe falciparum malaria by Conroy, Andrea L., Datta, Dibyadyuti, Hoffmann, Angelika, Wassmer, Samuel C.

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CD8+ T cells and human cerebral malaria: a shifting episteme by Rénia, Laurent, Grau, Georges Er, Wassmer, Samuel C

“…Mosquito-transmitted Plasmodium falciparum infection can cause human cerebral malaria (HCM) with high mortality rates. The abundance of infected red blood…”
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Gliding motility of Plasmodium merozoites by Yahata, Kazuhide, Hart, Melissa N., Davies, Heledd, Asada, Masahito, Wassmer, Samuel C., Templeton, Thomas J., Treeck, Moritz, Moon, Robert W., Kaneko, Osamu

“…Plasmodium malaria parasites are obligate intracellular protozoans that use a unique form of locomotion, termed gliding motility, to move through host tissues…”
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Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood-brain barrier in cerebral malaria by Adams, Yvonne, Olsen, Rebecca W, Bengtsson, Anja, Dalgaard, Nanna, Zdioruk, Mykola, Satpathi, Sanghamitra, Behera, Prativa K, Sahu, Praveen K, Lawler, Sean E, Qvortrup, Klaus, Wassmer, Samuel C, Jensen, Anja T R

“…Cerebral malaria (CM) is caused by the binding of Plasmodium falciparum-infected erythrocytes (IEs) to the brain microvasculature, leading to inflammation,…”
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Author Correction for Hochman et al., Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection by Hochman, Sarah E, Madaline, Theresa F, Wassmer, Samuel C, Mbale, Emmie, Choi, Namjong, Seydel, Karl B, Whitten, Richard O, Varughese, Julie, Grau, Georges E R, Kamiza, Steve, Molyneux, Malcolm E, Taylor, Terrie E, Lee, Sunhee, Milner, Jr, Danny A, Kim, Kami

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