Search Results - "Wassink, Melissa"

Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation by den Brok, Martijn H., Büll, Christian, Wassink, Melissa, de Graaf, Annemarie M., Wagenaars, Jori A., Minderman, Marthe, Thakur, Mayank, Amigorena, Sebastian, Rijke, Eric O., Schrier, Carla C., Adema, Gosse J.

“…Saponin-based adjuvants (SBAs) are being used in animal and human (cancer) vaccines, as they induce protective cellular immunity. Their adjuvant potency is a…”
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Targeting aberrant sialylation in cancer cells using a fluorinated sialic acid analog impairs adhesion, migration, and in vivo tumor growth by Büll, Christian, Boltje, Thomas J, Wassink, Melissa, de Graaf, Annemarie M A, van Delft, Floris L, den Brok, Martijn H, Adema, Gosse J

“…Cancer cells decorate their surface with a dense layer of sialylated glycans by upregulating the expression of sialyltransferases and other glycogenes…”
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Mechanical high-intensity focused ultrasound creates unique tumor debris enhancing dendritic cell-induced T cell activation by van den Bijgaart, Renske J E, Mekers, Vera E, Schuurmans, Fabian, Raaijmakers, Tonke K, Wassink, Melissa, Veltien, Andor, Dumont, Erik, Heerschap, Arend, Fütterer, Jurgen J, Adema, Gosse J

“…tumor ablation releases a unique repertoire of antigens from a heterogeneous population of tumor cells. High-intensity focused ultrasound (HIFU) is a…”
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Combined sialic acid and histone deacetylase (HDAC) inhibitor treatment up-regulates the neuroblastoma antigen GD2 by van den Bijgaart, Renske J.E., Kroesen, Michiel, Wassink, Melissa, Brok, Ingrid C., Kers-Rebel, Esther D., Boon, Louis, Heise, Torben, van Scherpenzeel, Monique, Lefeber, Dirk J., Boltje, Thomas J., den Brok, Martijn H., Hoogerbrugge, Peter M., Büll, Christian, Adema, Gosse J.

“…Neuroblastoma cells highly express the disialoganglioside GD2, a tumor-associated carbohydrate antigen, which is only sparsely expressed on healthy tissue. GD2…”
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Immune Adjuvant Efficacy of CpG Oligonucleotide in Cancer Treatment Is Founded Specifically upon TLR9 Function in Plasmacytoid Dendritic Cells by NIERKENS, Stefan, DEN BROK, Martijn H, ADEMA, Gosse J, JANSSEN, Edith M, GARCIA, Zacharias, TOGHER, Susan, WAGENAARS, Jori, WASSINK, Melissa, BOON, Louis, RUERS, Theo J, FIGDOR, Carl G, SCHOENBERGER, Stephen P

“…The differences in function, location, and migratory pattern of conventional dendritic cells (cDC) and plasmacytoid DCs (pDC) not only point to specialized…”
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A transplantable TH‐MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastoma by Kroesen, Michiel, Nierkens, Stefan, Ansems, Marleen, Wassink, Melissa, Orentas, Rimas J., Boon, Louis, Brok, Martijn H., Hoogerbrugge, Peter M., Adema, Gosse J.

“…Current multimodal treatments for patients with neuroblastoma (NBL), including anti‐disialoganglioside (GD2) monoclonal antibody (mAb) based immunotherapy,…”
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Anti-GD2 antibody and Vorinostat immunocombination therapy is highly effective in an aggressive orthotopic neuroblastoma model by van den Bijgaart, Renske J E, Kroesen, Michiel, Brok, Ingrid C, Reijnen, Daphne, Wassink, Melissa, Boon, Louis, Hoogerbrugge, Peter M, Adema, Gosse J

“…Neuroblastoma is a childhood malignancy and in the majority of patients, the primary tumor arises in one of the adrenal glands. Neuroblastoma cells highly…”
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Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes by Raaijmakers, Tonke K, van den Bijgaart, Renske J E, den Brok, Martijn H, Wassink, Melissa, de Graaf, Annemarie, Wagenaars, Jori A, Nierkens, Stefan, Ansems, Marleen, Scheffer, Gert Jan, Adema, Gosse J

“…BackgroundTumor ablation techniques, like cryoablation, are successfully used in the clinic to treat tumors. The tumor debris remaining in situ after ablation…”
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Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell-Mediated Tumor Immunity by Büll, Christian, Boltje, Thomas J, Balneger, Natasja, Weischer, Sarah M, Wassink, Melissa, van Gemst, Jasper J, Bloemendal, Victor R, Boon, Louis, van der Vlag, Johan, Heise, Torben, den Brok, Martijn H, Adema, Gosse J

“…Sialic acid sugars on the surface of cancer cells have emerged as potent immune modulators that contribute to the immunosuppressive microenvironment and tumor…”
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Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma by Kroesen, Michiel, Büll, Christian, Gielen, Paul R., Brok, Ingrid C., Armandari, Inna, Wassink, Melissa, Looman, Maaike W. G., Boon, Louis, den Brok, Martijn H., Hoogerbrugge, Peter M., Adema, Gosse J.

“…Neuroblastoma (NBL) is a childhood malignancy of the sympathetic nervous system. For high-risk NBL patients, the mortality rate is still over 50%, despite…”
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In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology by Hoogenboom, Martijn, Eikelenboom, Dylan, den Brok, Martijn H., Veltien, Andor, Wassink, Melissa, Wesseling, Pieter, Dumont, Erik, Fütterer, Jurgen J., Adema, Gosse J., Heerschap, Arend

“…Boiling histotripsy (BH) is a new high intensity focused ultrasound (HIFU) ablation technique to mechanically fragmentize soft tissue into submicrometer…”
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In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology: In vivo MR Guided Boiling Histotripsy by Hoogenboom, Martijn, Eikelenboom, Dylan, den Brok, Martijn H., Veltien, Andor, Wassink, Melissa, Wesseling, Pieter, Dumont, Erik, Fütterer, Jurgen J., Adema, Gosse J., Heerschap, Arend

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A transplantable TH-MYCN transgenic tumor model in C57B1/6 mice for preclinical immunological studies in neuroblastoma by KROESEN, Michiel, NIERKENS, Stefan, ANSEMS, Marleen, WASSINK, Melissa, ORENTAS, Rimas J, BOON, Louis, DEN BROK, Martijn H, HOOGERBRUGGE, Peter M, ADEMA, Gosse J

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Effects of light brushing on clinical pain intensity and experimental pain sensitivity in fibromyalgia patients by Wassink, Melissa

“…Context: The Graston Technique (GT) is an instrument-assisted soft tissue mobilization technique based on the concepts of manual therapy, which has been proven…”
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Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals by Hoogenboom, Martijn, van Amerongen, Martinus J, Eikelenboom, Dylan C, Wassink, Melissa, den Brok, Martijn H, Hulsbergen-van de Kaa, Christina, Dumont, Erik, Adema, Gosse J, Heerschap, Arend, Fütterer, Jurgen J

“…Thermal and mechanical high intensity focused ultrasound (HIFU) ablation techniques are in development for non-invasive treatment of cancer. However, knowledge…”
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Abstract 8670: Homocysteine Induces Reactive Oxygen Species-dependent Apoptosis of Arterial Smooth Muscle Cells Coinciding with (peri)nuclear Nox4 Translocation by Hahn, Nynke E, Sipkens, Jessica A, wassink, Melissa, Vonk, Alexander B, Stehouwer, Coen D, Rauwerda, Jan A, van Hinsbergh, Victor W, Meischl, Christof, Niessen, Hans W, Krijnen, Paul A

“…Abstract only Background: Elevated levels of homocysteine form a vascular risk factor. Although a jeopardizing role of homocysteine on endothelial cells has…”
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Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox) by Sipkens, Jessica A, Krijnen, Paul A J, Hahn, Nynke E, Wassink, Melissa, Meischl, Christof, Smith, Desirée E C, Musters, René J P, Stehouwer, Coen D A, Rauwerda, Jan A, van Hinsbergh, Victor W M, Niessen, Hans W M

“…We previously found that homocysteine (Hcy) induced plasma membrane flip-flop, apoptosis, and necrosis in cardiomyocytes. Inactivation of flippase by Hcy…”
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Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47^sup phox by Sipkens, Jessica A, Krijnen, Paul A; J, Hahn, Nynke E, Wassink, Melissa, Meischl, Christof, Smith, Desirée E; C, Musters, René J; P, Stehouwer, Coen D; A, Rauwerda, Jan A, van Hinsbergh, Victor W; M, Niessen, Hans W; M

“…We previously found that homocysteine (Hcy) induced plasma membrane flip-flop, apoptosis, and necrosis in cardiomyocytes. Inactivation of flippase by Hcy…”
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Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear [p47.sup.phox] by Sipkens, Jessica A, Krijnen, Paul A.J, Hahn, Nynke E, Wassink, Melissa, Meischl, Christof, Smith, Desiree E.C, Musters, Rene J.P, Stehouwer, Coen D.A, Rauwerda, Jan A, van Hinsbergh, Victor W.M, Niessen, Hans W.M

“…We previously found that homocysteine (Hcy) induced plasma membrane flip-flop, apoptosis, and necrosis in cardiomyocytes. Inactivation of flippase by Hcy…”
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Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47phox by Sipkens, Jessica A., Krijnen, Paul A. J., Hahn, Nynke E., Wassink, Melissa, Meischl, Christof, Smith, Desirée E. C., Musters, René J. P., Stehouwer, Coen D. A., Rauwerda, Jan A., van Hinsbergh, Victor W. M., Niessen, Hans W. M.

“…We previously found that homocysteine (Hcy) induced plasma membrane flip-flop, apoptosis, and necrosis in cardiomyocytes. Inactivation of flippase by Hcy…”
Get full text