Search Results - "Wasserman, R"

Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase by Wasserman, Michael R., Schauer, Grant D., O’Donnell, Michael E., Liu, Shixin

“…The eukaryotic replicative helicase CMG is a closed ring around double-stranded (ds)DNA at origins yet must transition to single-stranded (ss)DNA for helicase…”
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Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability by Meng, Fei-Long, Du, Zhou, Federation, Alexander, Hu, Jiazhi, Wang, Qiao, Kieffer-Kwon, Kyong-Rim, Meyers, Robin M., Amor, Corina, Wasserman, Caitlyn R., Neuberg, Donna, Casellas, Rafael, Nussenzweig, Michel C., Bradner, James E., Liu, X. Shirley, Alt, Frederick W.

“…Activation-induced cytidine deaminase (AID) initiates both somatic hypermutation (SHM) for antibody affinity maturation and DNA breakage for antibody class…”
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Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation by Wasserman, Michael R, Alejo, Jose L, Altman, Roger B, Blanchard, Scott C

“…Monitoring ribosomal translocation from five structural perspectives with pre–steady state smFRET defines intramolecular conformational events within the…”
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High-resolution structure of the Escherichia coli ribosome by Noeske, Jonas, Wasserman, Michael R, Terry, Daniel S, Altman, Roger B, Blanchard, Scott C, Cate, Jamie H D

“…High-resolution structure of the E. coli ribosome highlights rRNA and protein modifications and provides details on solvation characteristics and the…”
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Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses by Wang, Ling, Johnson, Zachary Lee, Wasserman, Michael R, Levring, Jesper, Chen, Jue, Liu, Shixin

“…ATP-binding cassette (ABC) transporters are molecular pumps ubiquitous across all kingdoms of life. While their structures have been widely reported, the…”
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Nucleosome-directed replication origin licensing independent of a consensus DNA sequence by Li, Sai, Wasserman, Michael R., Yurieva, Olga, Bai, Lu, O’Donnell, Michael E., Liu, Shixin

“…The numerous enzymes and cofactors involved in eukaryotic DNA replication are conserved from yeast to human, and the budding yeast Saccharomyces cerevisiae…”
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Crystal structure of the human PRMT5:MEP50 complex by Antonysamy, Stephen, Bonday, Zahid, Campbell, Robert M, Doyle, Brandon, Druzina, Zhanna, Gheyi, Tarun, Han, Bomie, Jungheim, Louis N, Qian, Yuewei, Rauch, Charles, Russell, Marijane, Sauder, J. Michael, Wasserman, Stephen R, Weichert, Kenneth, Willard, Francis S, Zhang, Aiping, Emtage, Spencer

“…Protein arginine methyltransferases (PRMTs) play important roles in several cellular processes, including signaling, gene regulation, and transport of proteins…”
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Reduction in medication errors in hospitals due to adoption of computerized provider order entry systems by Radley, David C, Wasserman, Melanie R, Olsho, Lauren Ew, Shoemaker, Sarah J, Spranca, Mark D, Bradshaw, Bethany

“…Medication errors in hospitals are common, expensive, and sometimes harmful to patients. This study's objective was to derive a nationally representative…”
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Vitamin D and the dual processes of intestinal calcium absorption by Wasserman, R H

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The bright future of single-molecule fluorescence imaging by Juette, Manuel F, Terry, Daniel S, Wasserman, Michael R, Zhou, Zhou, Altman, Roger B, Zheng, Qinsi, Blanchard, Scott C

“…•The potential impact of multi-color single-molecule FRET imaging.•Key requirement: ultra-stable fluorophores spanning the visible spectrum.•Intramolecularly…”
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Evaluation of correlation between dose and clinical outcomes in subcutaneous immunoglobulin replacement therapy by Orange, J. S., Belohradsky, B. H., Berger, M., Borte, M., Hagan, J., Jolles, S., Wasserman, R. L., Baggish, J. S., Saunders, R., Grimbacher, B.

“…Summary The importance of serum immunoglobulin (Ig)G concentration in IgG replacement therapy for primary immunodeficiency diseases is established in certain…”
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Subcutaneous immunoglobulin: facilitated infusion and advances in administration by Wasserman, R. L.

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C1 esterase inhibitor concentrate in 1085 Hereditary Angioedema attacks – final results of the I.M.P.A.C.T.2 study by Craig, T. J., Bewtra, A. K., Bahna, S. L., Hurewitz, D., Schneider, L. C., Levy, R. J., Moy, J. N., Offenberger, J., Jacobson, K. W., Yang, W. H., Eidelman, F., Janss, G., Packer, F. R., Rojavin, M. A., Machnig, T., Keinecke, H.‐O., Wasserman, R. L.

“…To cite this article: Craig TJ, Bewtra AK, Bahna SL, Hurewitz D, Schneider LC, Levy RJ, Moy JN, Offenberger J, Jacobson KW, Yang WH, Eidelman F, Janss G,…”
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The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates by Basu, Uttiya, Meng, Fei-Long, Keim, Celia, Grinstein, Veronika, Pefanis, Evangelos, Eccleston, Jennifer, Zhang, Tingting, Myers, Darienne, Wasserman, Caitlyn R., Wesemann, Duane R., Januszyk, Kurt, Gregory, Richard I., Deng, Haiteng, Lima, Christopher D., Alt, Frederick W.

“…Activation-induced cytidine deaminase (AID) initiates immunoglobulin (Ig) heavy-chain (IgH) class switch recombination (CSR) and Ig variable region somatic…”
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Allosteric control of the ribosome by small-molecule antibiotics by Wang, Leyi, Pulk, Arto, Wasserman, Michael R, Feldman, Michael B, Altman, Roger B, Cate, Jamie H Doudna, Blanchard, Scott C

“…Antibiotics target protein synthesis by binding and inhibiting key functional centers of the ribosome. Single-molecule imaging and X-ray crystallography…”
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Text-message responsiveness to blood glucose monitoring reminders is associated with HbA 1c benefit in teenagers with Type 1 diabetes by McGill, D E, Volkening, L K, Butler, D A, Wasserman, R M, Anderson, B J, Laffel, L M

“…To evaluate an 18-month text-messaging intervention in teenagers with Type 1 diabetes and to assess factors associated with text responsiveness and glycaemic…”
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Final Moments. II. Observational Properties and Physical Modeling of Circumstellar-material-interacting Type II Supernovae by Jacobson-Galán, W. V., Dessart, L., Davis, K. W., Kilpatrick, C. D., Margutti, R., Foley, R. J., Chornock, R., Terreran, G., Hiramatsu, D., Newsome, M., Padilla Gonzalez, E., Pellegrino, C., Howell, D. A., Filippenko, A. V., Anderson, J. P., Angus, C. R., Auchettl, K., Bostroem, K. A., Brink, T. G., Cartier, R., Coulter, D. A., de Boer, T., Drout, M. R., Earl, N., Ertini, K., Farah, J. R., Farias, D., Gall, C., Gao, H., Gerlach, M. A., Guo, F., Haynie, A., Hosseinzadeh, G., Ibik, A. L., Jha, S. W., Jones, D. O., Langeroodi, D., LeBaron, N, Magnier, E. A., Piro, A. L., Raimundo, S. I., Rest, A., Rest, S., Rich, R. Michael, Rojas-Bravo, C., Sears, H., Taggart, K., Villar, V. A., Wainscoat, R. J., Wang, X-F., Wasserman, A. R., Yan, S., Yang, Y., Zhang, J., Zheng, W.

“…Abstract We present ultraviolet/optical/near-infrared observations and modeling of Type II supernovae (SNe II) whose early time ( δ t < 2 days) spectra show…”
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Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes by Juette, Manuel F, Carelli, Jordan D, Rundlet, Emily J, Brown, Alan, Shao, Sichen, Ferguson, Angelica, Wasserman, Michael R, Holm, Mikael, Taunton, Jack, Blanchard, Scott C

“…Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals,…”
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Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions by Wasserman, Michael R., Pulk, Arto, Zhou, Zhou, Altman, Roger B., Zinder, John C., Green, Keith D., Garneau-Tsodikova, Sylvie, Doudna Cate, Jamie H., Blanchard, Scott C.

“…Dynamic remodelling of intersubunit bridge B2, a conserved RNA domain of the bacterial ribosome connecting helices 44 (h44) and 69 (H69) of the small and large…”
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Human Activities Attract Harmful Mosquitoes in a Tropical Urban Landscape by Lee, J. M., Wasserman, R. J., Gan, J. Y., Wilson, R. F., Rahman, S., Yek, S. H.

“…Knowledge of the interrelationship of mosquito communities and land use changes is of paramount importance to understand the potential risk of mosquito disease…”
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