Non-nutritive sweeteners: no class effect on the glycaemic or appetite responses to ingested glucose

There is considerable interest in whether non-nutritive sweeteners are sensed in the gastrointestinal tract to modulate appetitive or absorptive responses to ingested carbohydrate. We determined the effect of a panel of non-nutritive sweeteners, aspartame, saccharin and acesulfame-K, delivered in do...

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Bibliographic Details
Published in:	European journal of clinical nutrition Vol. 68; no. 5; pp. 629 - 631
Main Authors:	Bryant, C E, Wasse, L K, Astbury, N, Nandra, G, McLaughlin, J T
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-05-2014 Nature Publishing Group
Subjects:	631/443/319 692/700/2814 Absorptivity Adolescent Appetite Appetite - drug effects Artificial sweeteners Aspartame Aspartame - administration & dosage Biological and medical sciences Blood Blood Glucose - metabolism Blood sugar Body Mass Index Carbohydrates Clinical Nutrition Epidemiology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastrointestinal system Gastrointestinal tract Gastrointestinal Tract - drug effects Gastrointestinal Tract - metabolism Genetic aspects Glucose Glucose - administration & dosage Healthy Volunteers Human subjects Humans Hunger Internal Medicine Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Non-Nutritive Sweeteners - administration & dosage Non-Nutritive Sweeteners - classification Nutrients Physiological aspects Pilot Projects Public Health Saccharin Saccharin - administration & dosage short-communication Sweeteners Thiazines - administration & dosage Vertebrates: anatomy and physiology, studies on body, several organs or systems Young Adult United States United Kingdom Appetite Metabolic diseases Sweetener Glucose Nitric oxide Glycemia
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Summary:	There is considerable interest in whether non-nutritive sweeteners are sensed in the gastrointestinal tract to modulate appetitive or absorptive responses to ingested carbohydrate. We determined the effect of a panel of non-nutritive sweeteners, aspartame, saccharin and acesulfame-K, delivered in doses that would be consumed in normal usage. Each was given in combination with glucose, assessing their effect on glycemic responses and appetite in 10 healthy human subjects. There was no additional effect of aspartame or saccharin on the blood glucose response to oral glucose at any time point, although acesulfame-K exerted a small effect. However, none had an effect on perceptions of hunger or fullness. We conclude that there is no consistent evidence that non-nutrient sweeteners, when acutely consumed with glucose in dietetically relevant doses, have a class effect in modulating blood glucose in healthy human subjects. However, acesulfame-K may require further exploration.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0954-3007 1476-5640
DOI:	10.1038/ejcn.2014.19