Search Results - "Wason, Arpit"
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CPAP promotes timely cilium disassembly to maintain neural progenitor pool
Published in The EMBO journal (15-04-2016)“…A mutation in the centrosomal‐P4.1‐associated protein (CPAP) causes Seckel syndrome with microcephaly, which is suggested to arise from a decline in neural…”
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Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length
Published in Nature communications (16-06-2016)“…Centrioles and cilia are microtubule-based structures, whose precise formation requires controlled cytoplasmic tubulin incorporation. How cytoplasmic tubulin…”
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Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis
Published in Proceedings of the National Academy of Sciences - PNAS (21-01-2014)“…Pericentriolar material (PCM) recruitment to centrioles forms a key step in centrosome biogenesis. Deregulation of this process leads to centrosome aberrations…”
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Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2
Published in BMC cell biology (26-05-2023)“…DYX1C1 (DNAAF4) and DCDC2 are two of the most replicated dyslexia candidate genes in genetic studies. They both have demonstrated roles in neuronal migration,…”
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Inhibition of CPAP–tubulin interaction prevents proliferation of centrosome‐amplified cancer cells
Published in The EMBO journal (15-01-2019)“…Centrosome amplification is a hallmark of human cancers that can trigger cancer cell invasion. To survive, cancer cells cluster amplified extra centrosomes and…”
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Excess free histone H3 localizes to centrosomes for proteasome-mediated degradation during mitosis in metazoans
Published in Cell cycle (Georgetown, Tex.) (17-08-2016)“…The cell tightly controls histone protein levels in order to achieve proper packaging of the genome into chromatin, while avoiding the deleterious consequences…”
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Excess free histone H3 localizes to centrosomes for proteasome-mediated degradation during mitosis in metazoans
Published in Cell Cycle (17-08-2016)“…The cell tightly controls histone protein levels in order to achieve proper packaging of the genome into chromatin, while avoiding the deleterious consequences…”
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