Search Results - "Wasmuth, E"

The fractalkine receptor CX3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes by Karlmark, Karlin Raja, Zimmermann, Henning W., Roderburg, Christoph, Gassler, Nikolaus, Wasmuth, Hermann E., Luedde, Tom, Trautwein, Christian, Tacke, Frank

“…Chemokines modulate inflammatory responses that are prerequisites for organ fibrosis upon liver injury. Monocyte‐derived hepatic macrophages are critical for…”
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The chemokine CCL3 promotes experimental liver fibrosis in mice by Heinrichs, Daniel, Berres, Marie-Luise, Nellen, Andreas, Fischer, Petra, Scholten, David, Trautwein, Christian, Wasmuth, Hermann E, Sahin, Hacer

“…Liver fibrosis is associated with infiltrating immune cells and activation of hepatic stellate cells. We here aimed to investigate the effects of the CC…”
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Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice by Berres, Marie-Luise, Koenen, Rory R, Rueland, Anna, Zaldivar, Mirko Moreno, Heinrichs, Daniel, Sahin, Hacer, Schmitz, Petra, Streetz, Konrad L, Berg, Thomas, Gassler, Nikolaus, Weiskirchen, Ralf, Proudfoot, Amanda, Weber, Christian, Trautwein, Christian, Wasmuth, Hermann E

“…Activation of hepatic stellate cells in response to chronic inflammation represents a crucial step in the development of liver fibrosis. However, the molecules…”
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Functional role of chemokines in liver disease models by Trautwein, Christian, Sahin, Hacer, Wasmuth, Hermann E

“…Chemokines regulate the migration of immune cells into the liver in response to acute and chronic injuries and also have roles in stellate cell activation,…”
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Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74 by Heinrichs, Daniel, Knauel, Meike, Offermanns, Christian, Berres, Marie-Luise, Nellen, Andreas, Leng, Lin, Schmitz, Petra, Bucala, Richard, Trautwein, Christian, Weber, Christian, Bernhagen, Jürgen, Wasmuth, Hermann E

“…Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory cytokine that has been implicated in various inflammatory diseases. Chronic…”
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Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis by Queck, Alexander, Bode, Hannah, Uschner, Frank E, Brol, Maximilian J, Graf, Christiana, Schulz, Martin, Jansen, Christian, Praktiknjo, Michael, Schierwagen, Robert, Klein, Sabine, Trautwein, Christian, Wasmuth, Hermann E, Berres, Marie-Luise, Trebicka, Jonel, Lehmann, Jennifer

“…Monocyte chemotactic protein-1 (MCP-1) is a potent chemoattractant for monocytes. It is involved in pathogenesis of several inflammatory diseases. Hepatic…”
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Chemokines in liver inflammation and fibrosis by Wasmuth, Hermann E, Tacke, Frank, Trautwein, Christian

“…Chemokines are a class of small chemotactic molecules with cytokine-like functions, which are well known to orchestrate inflammatory responses within different…”
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Antifibrotic Effects of CXCL9 and Its Receptor CXCR3 in Livers of Mice and Humans by Wasmuth, Hermann E, Lammert, Frank, Zaldivar, Mirko Moreno, Weiskirchen, Ralf, Hellerbrand, Claus, Scholten, David, Berres, Marie-Luise, Zimmermann, Henning, Streetz, Konrad L, Tacke, Frank, Hillebrandt, Sonja, Schmitz, Petra, Keppeler, Hildegard, Berg, Thomas, Dahl, Edgar, Gassler, Nikolaus, Friedman, Scott L, Trautwein, Christian

“…Background & Aims Fibrosis is the hallmark of chronic liver diseases, yet many aspects of its mechanism remain to be defined. Chemokines are ubiquitous…”
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Value of magnifying chromoendoscopy and narrow band imaging (NBI) in classifying colorectal polyps: a prospective controlled study by Tischendorf, J J W, Wasmuth, H E, Koch, A, Hecker, H, Trautwein, C, Winograd, R

“…Chromoendoscopy in combination with magnifying endoscopy is useful in distinguishing neoplastic from non-neoplastic colorectal polyps. Narrow band imaging…”
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Overexpression of endoglin modulates TGF-β1-signalling pathways in a novel immortalized mouse hepatic stellate cell line by Meurer, Steffen K, Alsamman, Muhammad, Sahin, Hacer, Wasmuth, Hermann E, Kisseleva, Tatiana, Brenner, David A, Trautwein, Christian, Weiskirchen, Ralf, Scholten, David

“…Hepatic stellate cells (HSCs) play a major role in the pathogenesis of liver fibrosis. Working on primary HSCs requires difficult isolation procedures;…”
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Intrahepatic cholestasis of pregnancy: the severe form is associated with common variants of the hepatobiliary phospholipid transporter ABCB4 gene by Wasmuth, H E, Glantz, A, Keppeler, H, Simon, E, Bartz, C, Rath, W, Mattsson, L-Å, Marschall, H-U, Lammert, F

“…Background: Intrahepatic cholestasis of pregnancy (ICP) is characterised by troublesome maternal pruritus, raised serum bile acid levels and increased fetal…”
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Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis by Beraza, N, Malato, Y, Vander Borght, S, Liedtke, C, Wasmuth, H E, Dreano, M, de Vos, R, Roskams, T, Trautwein, C

“…Non-alcoholic-steatohepatitis (NASH) leading to fibrosis, end-stage cirrhosis and hepatocellular carcinoma is an increasing health problem in the Western…”
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Lack of interleukin‐6/glycoprotein 130/signal transducers and activators of transcription‐3 signaling in hepatocytes predisposes to liver steatosis and injury in mice by Kroy, Daniela C., Beraza, Naiara, Tschaharganeh, Darjus F., Sander, Leif E., Erschfeld, Stephanie, Giebeler, Arne, Liedtke, Christian, Wasmuth, Hermann E., Trautwein, Christian, Streetz, Konrad L.

“…A deregulated cytokine balance is involved in triggering the sequence from steatosis to nonalcoholic steatohepatitis, ultimately leading to liver fibrosis and…”
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Platelet Factor 4 Attenuates Experimental Acute Liver Injury in Mice by Drescher, Hannah K, Brandt, Elisa F, Fischer, Petra, Dreschers, Stephan, Schwendener, Reto A, Kowalska, M Anna, Canbay, Ali, Wasmuth, Hermann E, Weiskirchen, Ralf, Trautwein, Christian, Berres, Marie-Luise, Kroy, Daniela C, Sahin, Hacer

“…Platelet factor 4 (PF4) is a pleiotropic inflammatory chemokine, which has been implicated in various inflammatory disorders including liver fibrosis. However,…”
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c-Met Confers Protection Against Chronic Liver Tissue Damage and Fibrosis Progression After Bile Duct Ligation in Mice by Giebeler, Arne, Boekschoten, Mark V, Klein, Christian, Borowiak, Malgorzata, Birchmeier, Carmen, Gassler, Nikolaus, Wasmuth, Hermann E, Müller, Michael, Trautwein, Christian, Streetz, Konrad L

“…Background & Aims The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met) system is an essential inducer of hepatocyte growth and…”
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Patients with acute on chronic liver failure display ‘sepsis-like’ immune paralysis by Wasmuth, Hermann E., Kunz, Dagmar, Yagmur, Eray, Timmer-Stranghöner, Annette, Vidacek, Daniel, Siewert, Elmar, Bach, Jens, Geier, Andreas, Purucker, Edmund A., Gressner, Axel M., Matern, Siegfried, Lammert, Frank

“…Cellular immune depression is linked to high mortality in sepsis, but has yet to be systematically analysed in liver cirrhosis. The aim of the present study…”
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Unexpected Pro-Fibrotic Effect of MIF in Non-Alcoholic Steatohepatitis Is Linked to a Shift in NKT Cell Populations by Heinrichs, Daniel, Brandt, Elisa F, Fischer, Petra, Köhncke, Janine, Wirtz, Theresa H, Guldiken, Nurdan, Djudjaj, Sonja, Boor, Peter, Kroy, Daniela, Weiskirchen, Ralf, Bucala, Richard, Wasmuth, Hermann E, Strnad, Pavel, Trautwein, Christian, Bernhagen, Jürgen, Berres, Marie-Luise

“…Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory cytokine with anti-fibrotic properties in toxic liver injury models and…”
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Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver by Geier, Andreas, Dietrich, Christoph G, Voigt, Sebastian, Ananthanarayanan, Meenakshisundaram, Lammert, Frank, Schmitz, Anne, Trauner, Michael, Wasmuth, Hermann E, Boraschi, Diana, Balasubramaniyan, Natarajan, Suchy, Frederick J, Matern, Siegfried, Gartung, Carsten

“…Proinflammatory cytokines such as TNF-alpha and IL-1beta lead to downregulation of hepatic organic anion transporters in cholestasis. This adapted response is…”
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Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans by Lammert, Frank, Hillebrandt, Sonja, Wasmuth, Hermann E, Weiskirchen, Ralf, Hellerbrand, Claus, Keppeler, Hildegard, Werth, Alexa, Schirin-Sokhan, Ramin, Wilkens, Gabriele, Geier, Andreas, Lorenzen, Johann, Köhl, Jörg, Gressner, Axel M, Matern, Siegfried

“…Fibrogenesis or scarring of the liver is a common consequence of all chronic liver diseases. Here we refine a quantitative trait locus that confers…”
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Molecular Dissection of gp130-dependent Pathways in Hepatocytes during Liver Regeneration by Dierssen, Uta, Beraza, Naiara, Lutz, Holger H., Liedtke, Christian, Ernst, Matthias, Wasmuth, Hermann E., Trautwein, Christian

“…Interleukin-6 (IL-6) via its signal transducer gp130 is an important mediator of liver regeneration involved in protecting from lipopolysaccharide…”
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