Search Results - "Waskell, L"

Cytochrome b5, its functions, structure and membrane topology by Vergéres, G, Waskell, L

“…The first part of the present communication reviews recent advances in our understanding of the known physiological functions of cytochrome b5. In addition,…”
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Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: A new drug-drug interaction by LAU, Wei C, WASKELL, Lucy A, WATKINS, Paul B, NEER, Charlene J, HOROWITZ, Kevin, HOPP, Amy S, TAIT, Alan R, CARVILLE, David G. M, GUYER, Kirk E, BATES, Eric R

“…We observed that the prodrug clopidogrel was less effective in inhibiting platelet aggregation with coadministration of atorvastatin during point-of-care…”
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Construction of a 3D model of cytochrome P450 2B4 by Chang, Y T, Stiffelman, O B, Vakser, I A, Loew, G H, Bridges, A, Waskell, L

“…A three-dimensional structural model of rabbit phenobarbital-inducible cytochrome P450 2B4 (LM2) was constructed by homology modeling techniques previously…”
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NMR Studies of the Association of Cytochrome b5 with Cytochrome c by HOM, Kellie, MA, Qi-Feng, WOLFE, Gary, ZHANG, Hong, STORCH, Elizabeth M., DAGGETT, Valerie, BASUS, Vladimir J., WASKELL, Lucy

“…In an effort to gain greater insight into the molecular mechanism of the electron-transfer reactions of cytochrome b(5), the bovine cytochrome b(5)-horse…”
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Expression of cytochrome b5 in yeast and characterization of mutants of the membrane-anchoring domain by VERGERES, G, WASKELL, L

“…The soluble and membrane-bound forms of the synthetic rat cytochrome b5 gene have been expressed in Saccharomyces cerevisiae. In order to examine the topology…”
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Characterization of halothane oxidation by hepatic microsomes and purified cytochromes P-450 using a gas chromatographic mass spectrometric assay by Gruenke, L D, Konopka, K, Koop, D R, Waskell, L A

“…A sensitive assay for trifluoroacetic acid, the major product of the oxidative metabolism of halothane, has been developed to study the biotransformation of…”
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The function of tyrosine 74 of cytochrome b5 by Vergères, G, Chen, D Y, Wu, F F, Waskell, L

“…Tyrosine 74, which is part of a hydrophobic patch on the surface of rat cytochrome b5, also forms van der Waals contacts with the heme prosthetic group of the…”
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The identification of the heat-stable microsomal protein required for methoxyflurane metabolism as cytochrome b5 by Canova-Davis, E, Waskell, L

“…Methoxyflurane is an anesthetic whose metabolism by cytochrome P-450LM2 has been shown to be dependent upon a heat-stable microsomal protein (Canova-Davis, E.,…”
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Kinetics of the reduction of cytochrome b5 with mutations in its membrane-binding domain by Wu, F F, Vergères, G, Waskell, L

“…In an attempt to understand which amino acids in the membrane anchor of cytochrome b5 might be determinants of its ability to support the cytochrome…”
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Investigation of the rate limiting step for electron transfer from NADPH:cytochrome P450 reductase to cytochrome b5: a laser flash-photolysis study by Bhattacharyya, A K, Hurley, J K, Tollin, G, Waskell, L

“…The reduction kinetics of the one-electron-reduced cytochrome P450 reductase:cytochrome b5 complex (P450R1e:b5ox) has been investigated by the laser…”
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Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation by Cournoyer, Jason J., Pittman, Jason L., Ivleva, Vera B., Fallows, Eric, Waskell, Lucy, Costello, Catherine E., O'Connor, Peter B.

“…Deamidation of asparaginyl and isomerization of aspartyl residues in proteins proceed through a succinimide intermediate producing a mixture of aspartyl and…”
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Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase by Bridges, A, Gruenke, L, Chang, Y T, Vakser, I A, Loew, G, Waskell, L

“…A model of cytochrome P450 2B4, which was constructed by homology modeling with the four known crystal structures of the cytochromes P450 (Chang, T.-T.,…”
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Site of action of substrates requiring cytochrome b5 for oxidation by cytochrome P450 by Waskell, L A, Vigne, J L, Vergeres, G

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Peroxynitrite Inactivation of Human Cytochrome P450s 2B6 and 2E1: Heme Modification and Site-Specific Nitrotyrosine Formation by Lin, Hsia-lien, Myshkin, Eugene, Waskell, Lucy, Hollenberg, Paul F

“…This study examined the reaction of peroxynitrite (PN) with two human cytochrome P450s, P450 2B6 (2B6) and P450 2E1 (2E1). After the reaction with PN, the…”
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Identification by proton nuclear magnetic resonance of the histidines in cytochrome b5 modified by diethyl pyrocarbonate by Altman, John, Lipka, James J, Kuntz, Irwin, Waskell, Lucy

“…Diethyl pyrocarbonate (DEP) is an electrophilic reagent that is used to modify reversibly the histidine residues of proteins. Unfortunately, the lability of…”
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Methoxyflurane acts at the substrate binding site of cytochrome P450 LM2 to induce a dependence on cytochrome b5 by Lipka, J J, Waskell, L A

“…Rabbit cytochrome P450 isozyme 2 requires cytochrome b5 to metabolize the volatile anesthetic methoxyflurane but not the substrate benzphetamine [E…”
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I-653 resists degradation in rats by Koblin, D D, Eger, 2nd, E I, Johnson, B H, Konopka, K, Waskell, L

“…The ability of rats pretreated with phenobarbital to metabolize a new volatile anesthetic, I-653, was compared with the metabolism of halothane, isoflurane,…”
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Fluoride metabolites after prolonged exposure of volunteers and patients to desflurane by SUTTON, T. S, KOBLIN, D. D, GRUENKE, L. D, WEISKOPF, R. B, RAMPIL, I. J, WASKELL, L, EGER, E. I

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Theoretical study of the ligand-CYP2B4 complexes: Effect of structure on binding free energies and heme spin state by Harris, Danni L., Park, Jin-Young, Gruenke, Larry, Waskell, Lucy

“…The molecular origins of temperature‐dependent ligand‐binding affinities and ligand‐induced heme spin state conversion have been investigated using free energy…”
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Ethanol-inducible cytochrome P450 in rabbits metabolizes enflurane by Hoffman, J, Konopka, K, Buckhorn, C, Koop, D R, Waskell, L

“…Following anaesthesia with enflurane, some patients receiving isoniazid have increased serum concentrations of fluoride ion, presumably because of induction of…”
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