Search Results - "Wasif, Saif"

Pharmacokinetically Guided Dose Adjustment of 5-Fluorouracil: A Rational Approach to Improving Therapeutic Outcomes by Saif, M. Wasif, Choma, Adrienne, Salamone, Salvatore J., Chu, Edward

“…Chemotherapy dosing of the fluoropyrimidine 5-fluorouracil (5-FU) is currently based on body surface area. However, body surface area–based dosing has been…”
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Safety and Efficacy of Oxaliplatin and Fluoropyrimidine Regimens With or Without Bevacizumab As First-Line Treatment of Metastatic Colorectal Cancer: Results of the TREE Study by HOCHSTER, Howard S, HART, Lowell L, SCHWARTZBERG, Lee, HEDRICK, Eric, RAMANATHAN, Ramesh K, CHILDS, Barrett H, HAINSWORTH, John D, COHN, Allen L, WONG, Lucas, FEHRENBACHER, Louis, ABUBAKR, Yousif, WASIF SAIF, M

“…To evaluate the safety and efficacy of three oxaliplatin and fluoropyrimidine regimens, with or without bevacizumab, as first-line treatment for metastatic…”
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The Role of Src in Colon Cancer and Its Therapeutic Implications by Chen, Jiezhong, Elfiky, Aymen, Han, Mei, Chen, Chen, Saif, M. Wasif

“…Abstract Src is a member of a superfamily of membrane-associated nonreceptor protein tyrosine kinases. It is stimulated by receptors of growth hormone,…”
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Disparities in colorectal cancer in African-Americans vs Whites： Before and after diagnosis by Dimou, Anastasios, Syrigos, Kostas N, Saif, Muhammad Wasif

“…There are differences between African-American and white patients with colorectal cancer, concerning their characteristics before and after diagnosis. Whites…”
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Cutaneous Metastasis of Primary Small Intestinal Neuroendocrine Tumor: 2496 by Dhingra, Rohit, Saif, Wasif M., Tse, Julie Y.

“…Introduction: Neuroendocrine tumors (NETs) are neoplasms commonly found within the gastrointestinal tract (GIT) that originate from endocrine cells. These are…”
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Gastrointestinal perforation due to bevacizumab in colorectal cancer by Saif, Muhammad Wasif, Elfiky, Aymen, Salem, Ronald R

“…Bevacizumab is the first U.S. Food and Drug Association-approved vascular endothelial growth factor-targeted agent that greatly increases progression-free and…”
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Neoadjuvant therapy for pancreatic cancer: an ongoing debate by Russo, Suzanne, Wasif Saif, M.

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Treatment of Locally Advanced Pancreatic Cancer: The Role of Radiation Therapy by Johung, Kimberly, M.D., Ph.D, Saif, Muhammad Wasif, M.D., M.B.B.S, Chang, Bryan W., M.D

“…Pancreatic cancer remains associated with an extremely poor prognosis. Surgical resection can be curative, but the majority of patients present with locally…”
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The role of mTOR in the management of solid tumors: An overview by Strimpakos, Alex S, Karapanagiotou, Eleni M, Saif, M. Wasif, Syrigos, Kostas N

“…Summary Mammalian target of rapamycin (mTOR) is a key protein kinase controlling signal transduction from various growth factors and upstream proteins to the…”
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Management of Pancreatic Cancer During COVID-19 Pandemic: To Treat or Not to Treat? by Patel, Rajvi, Saif, Muhammad Wasif

“…Pancreatic cancer is a very aggressive disease and survival remains dismal even with treatment. Currently, management of patients with pancreatic cancer has…”
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Role of Pregabalin in Treatment of Oxaliplatin-induced Sensory Neuropathy by WASIF SAIF, Muhammad, SYRIGOS, Kostas, KALEY, Kristin, ISUFI, Iris

“…Oxaliplatin use in gastrointestinal malignancies is limited by neurotoxicity. This study aimed to assess the efficacy of pregabalin (LYRICA(R)) in the…”
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Gastric cancer and trastuzumab: first biologic therapy in gastric cancer by Gunturu, Krishna S., Woo, Yanghee, Beaubier, Nike, Remotti, Helen E., Saif, M. Wasif

“…Gastric cancer remains difficult to cure and has a poor overall prognosis. Chemotherapy and multimodality therapy has shown some benefit in the treatment of…”
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Selecting treatment options in refractory metastatic colorectal cancer by Byrne, Margaret, Saif, Muhammad Wasif

“…Survival of patients with metastatic colorectal cancer (mCRC) has significantly improved in the last decade. Survival gains are not driven by advances in…”
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Small cell carcinoma of the colon arising in a carcinoid tumor by Saif, M Wasif

“…Small cell carcinomas of the gastrointestinal tract are rare and clinically aggressive tumors. A case is presented of a 70 year-old woman who presented with…”
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Update on the role of nanoliposomal irinotecan in the treatment of metastatic pancreatic cancer by Rahman, FNU Asad ur, Ali, Saeed, Saif, Muhammad Wasif

“…Median survival for patients with metastatic pancreatic cancer (MPC) treated with combination chemotherapeutic agents such as gemcitabine-based regimens and…”
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Adenocarcinoma ex goblet cell carcinoid in a renal transplant patient: a case report and review of the literature by Saif, M Wasif

“…Adenocarcinoma ex goblet cell carcinoid is a rare neoplasm of appendiceal origin that contains features of both carcinoid tumor and adenocarcinoma. We report…”
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Overcoming the stromal barrier: technologies to optimize drug delivery in pancreatic cancer by Dimou, Anastasios, Syrigos, Konstantinos N., Saif, Muhammad Wasif

“…Pancreatic cancer has historically proven resistant to anticancer agents. On the one hand, drugs might be more efficient if higher levels could be achieved at…”
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Attenuated regimen of biweekly gemcitabine/nab-paclitaxel in patients aged 65 years or older with advanced pancreatic cancer by Rehman, Hasan, Chi, Jeffrey, Hakim, Nausheen, Goyal, Shreya Prasad, Olazagasti, Coral, Jose, Jyothi, Moriarty, Linda, Saif, Muhammad Wasif

“…Background: Treatment with gemcitabine/nab-paclitaxel confers a survival benefit over gemcitabine monotherapy in patients with advanced pancreatic cancer…”
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A DPYD Variant (Y186C) Specific to Individuals of African Descent in a Patient With Life-Threatening 5-FU Toxic Effects: Potential for an Individualized Medicine Approach by Saif, Muhammad Wasif, MD, Lee, Adam M., PhD, Offer, Steven M., PhD, McConnell, Kathleen, RN, Relias, Valerie, PharmD, Diasio, Robert B., MD

“…Abstract 5-Fluorouracil (5-FU) is commonly administered as a therapeutic agent for the treatment of various aggressive cancers. Severe toxic reactions to 5-FU…”
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New Drug and Possible New Toxicity - Squamous Cell Carcinoma Following Imatinib in Patients with Gastrointestinal Stromal Tumors by Inayat, Faisal, Saif, Muhammad Wasif

“…Molecularly targeted therapy has revolutionized the treatment of advanced gastrointestinal stromal tumors (GISTs). Specifically, the consistent dependence of…”
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