Search Results - "Washington, M. K."

Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway by Zhang, B, Zhang, B, Chen, X, Bae, S, Singh, K, Washington, M K, Datta, P K

“…Background: Higher frequency of Smad4 inactivation or loss of expression is observed in metastasis of colorectal cancer (CRC) leading to unfavourable survival…”
Get full text

Intra-Patient Heterogeneity in Micro-satellite-stable Colorectal Metastases: Does Immunotherapy Have a Role in Colorectal Peritoneal Metastases? by Mirza, M. B., Smith, P. Marincola, Wang, Y., Naveed, A., Washington, M. K., Xu, Y., Idrees, K.

Get full text

Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer by Grady, W M, Parkin, R K, Mitchell, P S, Lee, J H, Kim, Y-H, Tsuchiya, K D, Washington, M K, Paraskeva, C, Willson, J K V, Kaz, A M, Kroh, E M, Allen, A, Fritz, B R, Markowitz, S D, Tewari, M

“…MicroRNAs are small, non-coding RNAs that influence gene regulatory networks by post-transcriptional regulation of specific messenger RNA targets. MicroRNA…”
Get full text

Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation by Dhawan, P, Ahmad, R, Chaturvedi, R, Smith, J J, Midha, R, Mittal, M K, Krishnan, M, Chen, X, Eschrich, S, Yeatman, T J, Harris, R C, Washington, M K, Wilson, K T, Beauchamp, R D, Singh, A B

“…Claudin-2 is a unique member of the claudin family of transmembrane proteins, as its expression is restricted to the leaky epithelium in vivo and correlates…”
Get full text

Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesis by Bhat, A A, Pope, J L, Smith, J J, Ahmad, R, Chen, X, Washington, M K, Beauchamp, R D, Singh, A B, Dhawan, P

“…In normal colon, claudin-7 is one of the highly expressed claudin proteins and its knockdown in mice results in altered epithelial cell homeostasis and…”
Get full text

PIK3CA and APC mutations are synergistic in the development of intestinal cancers by Deming, D A, Leystra, A A, Nettekoven, L, Sievers, C, Miller, D, Middlebrooks, M, Clipson, L, Albrecht, D, Bacher, J, Washington, M K, Weichert, J, Halberg, R B

“…Human colorectal cancers are known to possess multiple mutations, though how these mutations interact in tumor development and progression has not been fully…”
Get full text

Composite Tissue Vasculopathy and Degeneration Following Multiple Episodes of Acute Rejection in Reconstructive Transplantation by Unadkat, J. V., Schneeberger, S., Horibe, E. H., Goldbach, C., Solari, M. G., Washington, K. M., Gorantla, V. S., Cooper, G. M., Thomson, A. W., Andrew Lee, W. P.

“…Transplant vasculopathy has not been systematically investigated in composite tissue allotransplantation (CTA). The impact of multiple acute rejections (ARs)…”
Get full text

Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia by Ray, K C, Moss, M E, Franklin, J L, Weaver, C J, Higginbotham, J, Song, Y, Revetta, F L, Blaine, S A, Bridges, L R, Guess, K E, Coffey, R J, Crawford, H C, Washington, M K, Means, A L

“…Pancreatic cancer remains as one of the most deadly cancers with few treatment options at late stages and little information about how it develops through…”
Get full text

Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis by Ahmad, R, Chaturvedi, R, Olivares-Villagómez, D, Habib, T, Asim, M, Shivesh, P, Polk, D B, Wilson, K T, Washington, M K, Van Kaer, L, Dhawan, P, Singh, A B

Get full text

Dilated intercellular space in chronic laryngitis and gastro‐oesophageal reflux disease: at baseline and post‐lansoprazole therapy by Vaezi, M. F., Slaughter, J. C., Smith, B. S., Washington, M. K., Jerome, W. G., Garrett, C. G., Hagaman, D., Goutte, M.

“…Aliment Pharmacol Ther 2010; 32: 916–924 Summary Background  Dilation of intercellular spaces is reported to be an early morphological marker in…”
Get full text

Establishing a tumour bank: banking, informatics and ethics by QUALMAN, S. J, FRANCE, M, GRIZZLE, W. E, LIVOLSI, V. A, MOSKALUK, C. A, RAMIREZ, N. C, WASHINGTON, M. K

“…The six divisions of the Cooperative Human Tissue Network in the USA bank and distribute tens of thousands of tissue specimens to researchers annually. Major…”
Get full text

Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling by Ahmad, R, Kumar, B, Chen, Z, Chen, X, Müller, D, Lele, S M, Washington, M K, Batra, S K, Dhawan, P, Singh, A B

“…The hyperactivated Wnt/β-catenin signaling acts as a switch to induce epithelial to mesenchymal transition and promote colorectal cancer. However, due to its…”
Get full text

Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor α by Song, Si Young, Gannon ‡, Maureen, Washington §, M.K., Scoggins, Charles R., Meszoely, Ingrid M., Goldenring ∥, James R., Marino ¶, Christopher R., Sandgren #, Eric P., Coffey, Robert J., Wright ‡, Christopher V.E., Leach ,‡, Steven D.

“…Background & Aims: The progenitor cells responsible for transforming growth factor (TGF)-α–induced pancreatic ductal metaplasia and neoplasia remain…”
Get full text

The effects of frozen tissue storage conditions on the integrity of RNA and protein by Auer, H, Mobley, J A, Ayers, L W, Bowen, J, Chuaqui, R F, Johnson, L A, Livolsi, V A, Lubensky, I A, McGarvey, D, Monovich, L C, Moskaluk, C A, Rumpel, C A, Sexton, K C, Washington, M K, Wiles, K R, Grizzle, W E, Ramirez, N C

“…Unfixed tissue specimens most frequently are stored for long term research uses at either -80° C or in vapor phase liquid nitrogen (VPLN). There is little…”
Get more information

EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis by Hardbower, D M, Coburn, L A, Asim, M, Singh, K, Sierra, J C, Barry, D P, Gobert, A P, Piazuelo, M B, Washington, M K, Wilson, K T

“…Epidermal growth factor receptor (EGFR) signaling is a known mediator of colorectal carcinogenesis. Studies have focused on the role of EGFR signaling in…”
Get full text

ΔNp73α regulates MDR1 expression by inhibiting p53 function by Vilgelm, A, Wei, J X, Piazuelo, M B, Washington, M K, Prassolov, V, El-Rifai, W, Zaika, A

“…The p73 protein is a transcription factor and member of the p53 protein family that expresses as a complex variety of isoforms. ΔNp73α is an N-terminally…”
Get full text

Investigation of Antibody-Mediated Rejection in Composite Tissue Allotransplantation in a Rat Limb Transplant Model by Unadkat, J.V, Schneeberger, S, Goldbach, C, Solari, M.G, Washington, K.M, Afrooz, P.N, Pulikkottil, B.J, Zheng, X.X, Lee, W.P.A

“…Abstract Background Despite the widely accepted implication of antidonor antibodies and complement in solid organ transplantation, their role in reconstructive…”
Get full text

Neonatal colonization of mice with LGG promotes intestinal development and decreases susceptibility to colitis in adulthood by Yan, F, Liu, L, Cao, H, Moore, D J, Washington, M K, Wang, B, Peek, R M, Acra, S A, Polk, D B

“…Development of the intestinal microbiota during early life serves as a key regulatory stage in establishing the host–microbial relationship. This symbiotic…”
Get full text

Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL–10 −/− mice by Shattuck-Brandt, Rebecca L., Varilek, Gary W., Radhika, Aramandla, Yang, Fajun, Washington, M.Kay, DuBois, Raymond N.

“…Background & Aims: The pathological and molecular changes associated with colitis-associated colorectal cancer and sporadic colorectal cancer are considered to…”
Get full text

Composite Tissue Allotransplantation for the Reconstruction of Congenital Craniofacial Defects by Washington, K.M, Zanoun, R.R, Cadogan, K.A, Afrooz, P.N, Losee, J.E

“…Abstract Facial disfigurement in children with congenital craniofacial defects can lead to decreased self-esteem and poor self-perception. Traditional methods…”
Get full text