Search Results - "Washington, M."

The new (Version 9) American Joint Committee on Cancer tumor, node, metastasis staging for cervical cancer by Olawaiye, Alexander B., Baker, Thomas P., Washington, M. Kay, Mutch, David G.

“…The American Joint Committee on Cancer (AJCC) tumor, node, metastasis (TNM) staging for all cancer sites has been periodically updated as a published manual…”
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Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models by Schulte, Michael L, Fu, Allie, Zhao, Ping, Li, Jun, Geng, Ling, Smith, Shannon T, Kondo, Jumpei, Coffey, Robert J, Johnson, Marc O, Rathmell, Jeffrey C, Sharick, Joe T, Skala, Melissa C, Smith, Jarrod A, Berlin, Jordan, Washington, M Kay, Nickels, Michael L, Manning, H Charles

“…A small molecule selectively targeting the cell-surface glutamine transporter ASCT2 disrupts glutamine signaling and metabolism. This compound displays low…”
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Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases by Zhao, Linlin, Washington, M Todd

“…DNA replication is constantly challenged by DNA lesions, noncanonical DNA structures and difficult-to-replicate DNA sequences. Two major strategies to rescue a…”
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Conformational flexibility of fork-remodeling helicase Rad5 shown by full-ensemble hybrid methods by Gildenberg, Melissa S, Washington, M Todd

“…Several pathways exist to bypass DNA damage during replication. One such pathway is template switching. The Rad5 protein plays two important roles in template…”
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Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin by Erdogan, Begum, Ao, Mingfang, White, Lauren M, Means, Anna L, Brewer, Bryson M, Yang, Lijie, Washington, M Kay, Shi, Chanjuan, Franco, Omar E, Weaver, Alissa M, Hayward, Simon W, Li, Deyu, Webb, Donna J

“…Cancer-associated fibroblasts (CAFs) are major components of the carcinoma microenvironment that promote tumor progression. However, the mechanisms by which…”
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Observed high-altitude warming and snow cover retreat over Tibet and the Himalayas enhanced by black carbon aerosols by Xu, Y, Ramanathan, V, Washington, W. M

“…Himalayan mountain glaciers and the snowpack over the Tibetan Plateau provide the headwater of several major rivers in Asia. In situ observations of snow cover…”
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Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells by Zhu, Shoumin, Soutto, Mohammed, Chen, Zheng, Blanca Piazuelo, M., Kay Washington, M., Belkhiri, Abbes, Zaika, Alexander, Peng, Dunfa, El-Rifai, Wael

“…Dopamine and cAMP-regulated phosphoprotein, Mr 32000 (DARPP-32), is frequently overexpressed in early stages of gastric cancers. We utilized in vitro assays,…”
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Making choices: DNA replication fork recovery mechanisms by Kondratick, Christine M., Washington, M. Todd, Spies, Maria

“…DNA replication is laden with obstacles that slow, stall, collapse, and break DNA replication forks. At each obstacle, there is a decision to be made whether…”
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Eukaryotic translesion synthesis: Choosing the right tool for the job by Powers, Kyle T., Washington, M. Todd

“…Normal DNA replication is blocked by DNA damage in the template strand. Translesion synthesis is a major pathway for overcoming these replication blocks. In…”
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Paeniclostridium sordellii uterine infection is dependent on the estrous cycle by Bernard, Sarah C, Washington, M Kay, Lacy, D Borden

“…Human infections caused by the toxin-producing, anaerobic and spore-forming bacterium Paeniclostridium sordellii are associated with a treatment-refractory…”
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Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection by Peritore-Galve, F Christopher, Shupe, John A, Cave, Rory J, Childress, Kevin O, Washington, M Kay, Kuehne, Sarah A, Lacy, D Borden

“…Clostridioides difficile infection (CDI) is the leading cause of nosocomial diarrhea and pseudomembranous colitis in the USA. In addition to these symptoms,…”
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Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation by Banerjee, Amrita, Herring, Charles A., Chen, Bob, Kim, Hyeyon, Simmons, Alan J., Southard-Smith, Austin N., Allaman, Margaret M., White, James R., Macedonia, Mary C., Mckinley, Eliot T., Ramirez-Solano, Marisol A., Scoville, Elizabeth A., Liu, Qi, Wilson, Keith T., Coffey, Robert J., Washington, M. Kay, Goettel, Jeremy A., Lau, Ken S.

“…Countries endemic for parasitic infestations have a lower incidence of Crohn’s disease (CD) than nonendemic countries, and there have been anecdotal reports of…”
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R.I.P. to the PIP: PCNA-binding motif no longer considered specific: PIP motifs and other related sequences are not distinct entities and can bind multiple proteins involved in genome maintenance by Boehm, Elizabeth M, Washington, M Todd

“…Many proteins responsible for genome maintenance interact with one another via short sequence motifs. The best known of these are PIP motifs, which mediate…”
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Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps by Chen, Bob, Scurrah, Cherie’ R., McKinley, Eliot T., Simmons, Alan J., Ramirez-Solano, Marisol A., Zhu, Xiangzhu, Markham, Nicholas O., Heiser, Cody N., Vega, Paige N., Rolong, Andrea, Kim, Hyeyon, Sheng, Quanhu, Drewes, Julia L., Zhou, Yuan, Southard-Smith, Austin N., Xu, Yanwen, Ro, James, Jones, Angela L., Revetta, Frank, Berry, Lynne D., Niitsu, Hiroaki, Islam, Mirazul, Pelka, Karin, Hofree, Matan, Chen, Jonathan H., Sarkizova, Siranush, Ng, Kimmie, Giannakis, Marios, Boland, Genevieve M., Aguirre, Andrew J., Anderson, Ana C., Rozenblatt-Rosen, Orit, Regev, Aviv, Hacohen, Nir, Kawasaki, Kenta, Sato, Toshiro, Goettel, Jeremy A., Grady, William M., Zheng, Wei, Washington, M. Kay, Cai, Qiuyin, Sears, Cynthia L., Goldenring, James R., Franklin, Jeffrey L., Su, Timothy, Huh, Won Jae, Vandekar, Simon, Roland, Joseph T., Liu, Qi, Coffey, Robert J., Shrubsole, Martha J., Lau, Ken S.

“…Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular heterogeneity, and immunogenic potential may reveal diagnostic and…”
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Loss of FOXA1/2 Is Essential for the Epithelial-to-Mesenchymal Transition in Pancreatic Cancer by YAN SONG, WASHINGTON, M. Kay, CRAWFORD, Howard C

“…FOXA1 and FOXA2, members of the forkhead transcription factor family, are critical for epithelial differentiation in many endoderm-derived organs, including…”
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The Many Roles of PCNA in Eukaryotic DNA Replication by Boehm, E M, Gildenberg, M S, Washington, M T

“…Proliferating cell nuclear antigen (PCNA) plays critical roles in many aspects of DNA replication and replication-associated processes, including translesion…”
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Nod1 Imprints Inflammatory and Carcinogenic Responses toward the Gastric Pathogen Helicobacter pylori by Suarez, Giovanni, Romero-Gallo, Judith, Piazuelo, Maria B, Sierra, Johanna C, Delgado, Alberto G, Washington, M Kay, Shah, Shailja C, Wilson, Keith T, Peek, Jr, Richard M

“…( ) is the strongest known risk for gastric cancer. The type IV secretion system is an oncogenic locus that translocates peptidoglycan into host cells, where…”
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Heme sensing and detoxification by HatRT contributes to pathogenesis during Clostridium difficile infection by Knippel, Reece J, Zackular, Joseph P, Moore, Jessica L, Celis, Arianna I, Weiss, Andy, Washington, M Kay, DuBois, Jennifer L, Caprioli, Richard M, Skaar, Eric P

“…Clostridium difficile is a Gram-positive, spore-forming anaerobic bacterium that infects the colon, causing symptoms ranging from infectious diarrhea to…”
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Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway by Zhang, B, Zhang, B, Chen, X, Bae, S, Singh, K, Washington, M K, Datta, P K

“…Background: Higher frequency of Smad4 inactivation or loss of expression is observed in metastasis of colorectal cancer (CRC) leading to unfavourable survival…”
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EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis by Ardito, Christine M., Grüner, Barbara M., Takeuchi, Kenneth K., Lubeseder-Martellato, Clara, Teichmann, Nicole, Mazur, Pawel K., DelGiorno, Kathleen E., Carpenter, Eileen S., Halbrook, Christopher J., Hall, Jason C., Pal, Debjani, Briel, Thomas, Herner, Alexander, Trajkovic-Arsic, Marija, Sipos, Bence, Liou, Geou-Yarh, Storz, Peter, Murray, Nicole R., Threadgill, David W., Sibilia, Maria, Washington, M. Kay, Wilson, Carole L., Schmid, Roland M., Raines, Elaine W., Crawford, Howard C., Siveke, Jens T.

“…Initiation of pancreatic ductal adenocarcinoma (PDA) is definitively linked to activating mutations in the KRAS oncogene. However, PDA mouse models show that…”
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