Search Results - "Washington, M Todd"

Eukaryotic translesion synthesis: Choosing the right tool for the job by Powers, Kyle T., Washington, M. Todd

“…Normal DNA replication is blocked by DNA damage in the template strand. Translesion synthesis is a major pathway for overcoming these replication blocks. In…”
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Conformational flexibility of fork-remodeling helicase Rad5 shown by full-ensemble hybrid methods by Gildenberg, Melissa S, Washington, M Todd

“…Several pathways exist to bypass DNA damage during replication. One such pathway is template switching. The Rad5 protein plays two important roles in template…”
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PCNA tool belts and polymerase bridges form during translesion synthesis by Boehm, Elizabeth M, Spies, Maria, Washington, M Todd

“…Large multi-protein complexes play important roles in many biological processes, including DNA replication and repair, transcription, and signal transduction…”
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Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases by Zhao, Linlin, Washington, M Todd

“…DNA replication is constantly challenged by DNA lesions, noncanonical DNA structures and difficult-to-replicate DNA sequences. Two major strategies to rescue a…”
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Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1 by Weaver, Tyler M., Click, Timothy H., Khoang, Thu H., Todd Washington, M., Agarwal, Pratul K., Freudenthal, Bret D.

“…Rev1 is a translesion DNA synthesis (TLS) polymerase involved in the bypass of adducted-guanine bases and abasic sites during DNA replication. During damage…”
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DNA Polymerase Fidelity: Beyond Right and Wrong by Washington, M. Todd

“…Accurate DNA replication depends on the ability of DNA polymerases to discriminate between correctly and incorrectly paired nucleotides. In this issue of…”
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Control of DNA Damage Bypass by Ubiquitylation of PCNA by Ripley, Brittany M, Gildenberg, Melissa S, Washington, M Todd

“…DNA damage leads to genome instability by interfering with DNA replication. Cells possess several damage bypass pathways that mitigate the effects of DNA…”
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KERA: analysis tool for multi-process, multi-state single-molecule data by Tibbs, Joseph, Ghoneim, Mohamed, Caldwell, Colleen C, Buzynski, Troy, Bowie, Wayne, Boehm, Elizabeth M, Washington, M Todd, Tabei, S M Ali, Spies, Maria

“…Abstract Molecular machines within cells dynamically assemble, disassemble and reorganize. Molecular interactions between their components can be observed at…”
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Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange by Freudenthal, Bret D, Ramaswamy, S, Washington, M Todd, Gakhar, Lokesh

“…The monoubiquitination of processivity factor PCNA at Lys164 in yeast leads to exchange of a replicative DNA polymerase with a translesion one. Now a…”
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Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops by Liu, Jie, Ede, Christopher, Wright, William D, Gore, Steven K, Jenkins, Shirin S, Freudenthal, Bret D, Todd Washington, M, Veaute, Xavier, Heyer, Wolf-Dietrich

“…Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome,…”
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Crystal structures of PCNA mutant proteins defective in gene silencing suggest a novel interaction site on the front face of the PCNA ring by Kondratick, Christine M, Litman, Jacob M, Shaffer, Kurt V, Washington, M Todd, Dieckman, Lynne M

“…Proliferating cell nuclear antigen (PCNA), a homotrimeric protein, is the eukaryotic sliding clamp that functions as a processivity factor for polymerases…”
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Structurally Distinct Ubiquitin- and Sumo-Modified PCNA: Implications for Their Distinct Roles in the DNA Damage Response by Tsutakawa, Susan E., Yan, Chunli, Xu, Xiaojun, Weinacht, Christopher P., Freudenthal, Bret D., Yang, Kun, Zhuang, Zhihao, Washington, M. Todd, Tainer, John A., Ivanov, Ivaylo

“…Proliferating cell nuclear antigen (PCNA) is a pivotal replication protein, which also controls cellular responses to DNA damage. Posttranslational…”
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Variations on a theme: Eukaryotic Y-family DNA polymerases by Washington, M. Todd, Carlson, Karissa D., Freudenthal, Bret D., Pryor, John M.

“…Most classical DNA polymerases, which function in normal DNA replication and repair, are unable to synthesize DNA opposite damage in the template strand. Thus…”
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Identification of New Mutations at the PCNA Subunit Interface that Block Translesion Synthesis by Kondratick, Christine M, Boehm, Elizabeth M, Dieckman, Lynne M, Powers, Kyle T, Sanchez, Julio C, Mueting, Samuel R, Washington, M Todd

“…Proliferating cell nuclear antigen (PCNA) plays an essential role in DNA replication and repair by interacting with a large number of proteins involved in…”
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Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA by Tsutakawa, Susan E, Van Wynsberghe, Adam W, Freudenthal, Bret D, Weinacht, Christopher P, Gakhar, Lokesh, Washington, M. Todd, Zhuang, Zhihao, Tainer, John A, Ivanov, Ivaylo

“…PCNA ubiquitination in response to DNA damage leads to the recruitment of specialized translesion polymerases to the damage locus. This constitutes one of the…”
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Dead-End Elimination with a Polarizable Force Field Repacks PCNA Structures by LuCore, Stephen D., Litman, Jacob M., Powers, Kyle T., Gao, Shibo, Lynn, Ava M., Tollefson, William T.A., Fenn, Timothy D., Washington, M. Todd, Schnieders, Michael J.

“…A balance of van der Waals, electrostatic, and hydrophobic forces drive the folding and packing of protein side chains. Although such interactions between…”
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Modeling Conformationally Flexible Proteins With X-ray Scattering and Molecular Simulations by Powers, Kyle T., Gildenberg, Melissa S., Washington, M. Todd

“…Proteins and protein complexes with high conformational flexibility participate in a wide range of biological processes. These processes include genome…”
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Distinct Structural Alterations in Proliferating Cell Nuclear Antigen Block DNA Mismatch Repair by Dieckman, Lynne M, Boehm, Elizabeth M, Hingorani, Manju M, Washington, M. Todd

“…During DNA replication, mismatches and small loops in the DNA resulting from insertions or deletions are repaired by the mismatch repair (MMR) machinery…”
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Pre-steady state kinetic studies show that an abasic site is a cognate lesion for the yeast Rev1 protein by Pryor, John M., Washington, M. Todd

“…► The mechanisms of nucleotide incorporation by yeast and human Rev1 are similar. ► Only a small fraction of Rev1 molecules are capable of rapid nucleotide…”
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Crystal Structure of SUMO-Modified Proliferating Cell Nuclear Antigen by Freudenthal, Bret D., Brogie, John E., Gakhar, Lokesh, Kondratick, Christine M., Washington, M. Todd

“…Eukaryotic proliferating cell nuclear antigen (PCNA) is a replication accessory protein that functions in DNA replication, repair, and recombination. The…”
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