Search Results - "Washburn, W N"

Suicide-inhibitory bifunctionally linked substrates (SIBLINKS) as phospholipase A2 inhibitors. Mechanistic implications by Washburn, W N, Dennis, E A

“…Novel phospholipids that function as mechanism-based inhibitors for phospholipase A2 (PLA2) are described. PLA2-catalyzed hydrolysis of the sn-2 ester of these…”
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Arylpropanolamines : Selective β3 agonists arising from strategies to mitigate phase I metabolic transformations by WASHBURN, W. N, HARPER, T. W, DEJNEKA, T, AHMED, S, CARINGAL, Y, HANGELAND, J, ZHANG, M, CHENG, P. T. W, RUSSELL, A. D, SKWISH, S, SLUSARCHYK, D. A, ALLEN, G. T, WU, G, FROHLICH, B. H, ABBOA-OFFEI, B. E, CAP, M, WALDRON, T. L, GEORGE, R. J, TESFAMARIAM, B, DICKINSON, K. E, SEYMOUR, A. A, SHER, P. M, GODFREY, J. D, MCCANN, P, GIROTRA, R, SHAO, C, ZHANG, H, GAVAI, A, MIKKILINENI, A

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BMS-196085 : A potent and selective full agonist of the human β3 adrenergic receptor by GAVAI, A. V, SHER, P. M, WANG, T. C, SUN, C. Q, SLUSARCHYK, D. A, SKWISH, S, ALLEN, G. T, HILLYER, D. E, FROHLICH, B. H, ABBOA-OFFEI, B. E, CAP, M, WALDRON, T. L, MIKKILINENI, A. B, GEORGE, R. J, TESFAMARIAM, B, HARPER, T. W, CIOSEK, C. P, YOUNG, D. A, DICKINSON, K. E, SEYMOUR, A. A, ARBEENY, C. M, WASHBURN, W. N, POSS, K. M, MCCANN, P. J, GIROTRA, R. N, FISHER, L. G, WU, G, BEDNARZ, M. S, MATHUR, A

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BMS-201620: a selective beta 3 agonist by Washburn, W.N., Sun, C.-Q., Bisacchi, G., Wu, G., Cheng, P.T., Sher, P.M., Ryono, D., Gavai, A.V., Poss, K., Girotra, R.N., McCann, P.J., Mikkilineni, A.B., Dejneka, T.C., Wang, T.C., Merchant, Z., Morella, M., Arbeeny, C.M., Harper, T.W., Slusarchyk, D.A., Skwish, S., Russell, A.D., Allen, G.T., Tesfamariam, B., Frohlich, B.H., Abboa-Offei, B.E., Cap, M., Waldron, T.L., George, R.J., Young, D., Dickinson, K.E., Seymour, A.A.

“…Graphic A series of N-(4-hydroxy-3-methylsulfonanilidoethanol)arylglycinamides were prepared and evaluated for their human β 3 adrenergic receptor agonist…”
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Intramolecular nucleophilic catalysis during alkaline hydrolysis of nonenolizable .beta.-keto esters by Washburn, William N, Cook, Ewell R

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Assay strategies and methods for phospholipases by Reynolds, L J, Washburn, W N, Deems, R A, Dennis, E A

“…Of the general considerations discussed, the two issues which are most important in choosing an assay are (1) what sensitivity is required to assay a…”
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BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor by Gavai, A V, Sher, P M, Mikkilineni, A B, Poss, K M, McCann, P J, Girotra, R N, Fisher, L G, Wu, G, Bednarz, M S, Mathur, A, Wang, T C, Sun, C Q, Slusarchyk, D A, Skwish, S, Allen, G T, Hillyer, D E, Frohlich, B H, Abboa-Offei, B E, Cap, M, Waldron, T L, George, R J, Tesfamariam, B, Harper, T W, Ciosek, Jr, C P, Young, D A, Dickinson, K E, Seymour, A A, Arbeeny, C M, Washburn, W N

“…A series of 4-hydroxy-3-methylsulfonanilido-1,2-diarylethylamines were prepared and evaluated for their human beta(3) adrenergic receptor agonist activity. SAR…”
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Bishomoaromatic stabilization of bicyclic anions by Washburn, William N

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Arylpropanolamines: Selective beta sub(3) agonists arising from strategies to mitigate phase I metabolic transformations by Washburn, W N, Harper, T W, Wu, G, Godfrey, J D, McCann, P, Girotra, R, Shao, C, Zhang, H, Gavai, A, Mikkilineni, A, Dejneka, T, Ahmed, S, Caringal, Y, Hangeland, J, Zhang, M, Cheng, PTW, Russell, AD, Skwish, S, Slusarchyk, DA, Allen, G T, Frohlich, B H, Abboa-Offei, B E, Cap, M, Waldron, T L, George, R J, Tesfamariam, B, Dickinson, KE, Seymour, A A, Sher, P M

“…Utilization of N-substituted-4-hydroxy-3-methylsulfonanilidoethanolamines 1 as selective beta sub(3) agonists is complicated by their propensity to undergo…”
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Arylpropanolamines: selective beta3 agonists arising from strategies to mitigate phase I metabolic transformations by Washburn, W N, Harper, T W, Wu, G, Godfrey, J D, McCann, P, Girotra, R, Shao, C, Zhang, H, Gavai, A, Mikkilineni, A, Dejneka, T, Ahmed, S, Caringal, Y, Hangeland, J, Zhang, M, Cheng, P T W, Russell, A D, Skwish, S, Slusarchyk, D A, Allen, G T, Frohlich, B H, Abboa-Offei, B E, Cap, M, Waldron, T L, George, R J, Tesfamariam, B, Dickinson, K E, Seymour, A A, Sher, P M

“…Utilization of N-substituted-4-hydroxy-3-methylsulfonanilidoethanolamines 1 as selective beta(3) agonists is complicated by their propensity to undergo…”
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Beta 3 agonists. Part 1: evolution from inception to BMS-194449 by Washburn, W.N., Sher, P.M., Poss, K.M., Girotra, R.N., McCann, P.J., Gavai, A.V., Mikkilineni, A.B., Mathur, A., Cheng, P., Dejneka, T.C., Sun, C.Q., Wang, T.C., Harper, T.W., Russell, A.D., Slusarchyk, D.A., Skwish, S., Allen, G.T., Hillyer, D.E., Frohlich, B.H., Abboa-Offei, B.E., Cap, M., Waldron, T.L., George, R.J., Tesfamariam, B., Ciosek, C.P., Ryono, D., Young, D.A., Dickinson, K.E., Seymour, A.A., Arbeeny, C.M., Gregg, R.E.

“…Screening of the BMS collection identified 4-hydroxy-3-methylsulfonanilidoethanolamines as full beta 3 agonists. Substitution of the ethanolamine nitrogen with…”
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Role of the symbiotic algae of Plexaura homomalla in prostaglandin biosynthesis by Corey, E. J, Washburn, William N

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Introduction of a 9(11) double bond into steroids by selective free-radical halogenation by Breslow, Ronald, Dale, James A, Kalicky, Paul, Liu, Sophia Y, Washburn, William N

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C-Arylglucoside synthesis: triisopropylsilane as a selective reagent for the reduction of an anomeric C-phenyl ketal by Ellsworth, Bruce A., Doyle, Abigail G., Patel, Manorama, Caceres-Cortes, Janet, Meng, Wei, Deshpande, Prashant P., Pullockaran, Annie, Washburn, William N.

“…Reduction of tetra- O-benzyl-protected 1 C-phenylglucoside using triethylsilane and BF 3·OEt 2 has been reported (Czernecki, S.; Ville, G. J. Org. Chem. 1989,…”
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Suicide-inhibitory bifunctionally substrates (SIBLINKS) as phospholipase A2 inhibitors : mechanistic implications by WASHBURN, W. N, DENNIS, E. A

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Asymmetric induction arising from ο/π interactions by WASHBURN, W. N, HILLSON, R. A

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Studies on the prostaglandin A 2 synthetase complex from Plexaura homomalla by Corey, E J, Washburn, W N, Chen, J C

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Asymmetric induction arising from .sigma./.pi. interactions by Washburn, William N, Hillson, Randall A

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Formation of the totally degenerate bicyclo[3.2.2]nonatrienyl radical by electron transfer by Washburn, William N

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Generation of bicyclo[3.1.0]hexatriene. Reactive intermediate by Washburn, William N

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