Elevated Interleukin-31 Levels in Serum, but Not CSF of Dogs with Steroid-Responsive Meningitis-Arteritis Suggest an Involvement in Its Pathogenesis

Elevated Interleukin-31 Levels in Serum, but Not CSF of Dogs with Steroid-Responsive Meningitis-Arteritis Suggest an Involvement in Its Pathogenesis

Steroid-responsive meningitis-arteritis (SRMA) is a predominantly Th-2 immune-mediated disease, but the exact pathomechanism remains unclear. Interleukin-31 (IL-31) is predominantly produced by T cells with a Th-2 phenotype during proinflammatory conditions. We hypothesize that IL-31 might be involv...

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Bibliographic Details
Published in:Animals (Basel) Vol. 13; no. 16; p. 2676
Main Authors: Lemke, Laura, Carlson, Regina, Warzecha, Katrin, Volk, Andrea V, Tipold, Andrea, Nessler, Jasmin
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-08-2023
MDPI
Subjects:
Atopic dermatitis
canine
Cerebrospinal fluid
Cytokines
Dermatitis
Dogs
Enzyme-linked immunosorbent assay
IL-31
Interleukins
Magnetic resonance imaging
Meningitis
meningoencephalitis of unknown origin
MUO
Neck pain
Normal distribution
Pathogenesis
SRMA
Statistical analysis
Steroids
T cells
Th-2 mediated inflammation
Veterinary medicine
Germany
United States > US
meningoencephalitis of unknown origin
canine
SRMA
MUO
Th-2 mediated inflammation
IL-31
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Summary:Steroid-responsive meningitis-arteritis (SRMA) is a predominantly Th-2 immune-mediated disease, but the exact pathomechanism remains unclear. Interleukin-31 (IL-31) is predominantly produced by T cells with a Th-2 phenotype during proinflammatory conditions. We hypothesize that IL-31 might be involved in the pathogenesis of SRMA. IL-31 was measured in archived samples (49 serum and 52 CSF samples) of dogs with SRMA, meningoencephalitis of unknown origin (MUO), infectious meningoencephalitis, and atopic dermatitis, and of healthy control dogs using a competitive canine IL-31 ELISA. The mean serum IL-31 level in dogs with SRMA ( = 18) was mildly higher compared to dogs with atopic dermatitis ( = 3, = 0.8135) and MUO ( = 15, = 0.7618) and markedly higher than in healthy controls ( = 10, = 0.1327) and dogs with infectious meningoencephalitis ( = 3, no statistics). Dogs with SRMA in the acute stage of the disease and without any pre-treatment had the highest IL-31 levels. The mean CSF IL-31 value for dogs with SRMA ( = 23) was quite similar to that for healthy controls ( = 8, = 0.4454) and did not differ markedly from dogs with MUO ( = 19, = 0.8724) and infectious meningoencephalitis. Based on this study, an involvement of IL-31 in the pathogenesis of the systemic Th-2 immune-mediated immune response in SRMA can be assumed as a further component leading to an aberrant immune reaction.
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content type line 23
ISSN:2076-2615
2076-2615
DOI:10.3390/ani13162676