Search Results - "Warth, Arne"

Spread through air spaces (STAS): a comprehensive update by Warth, Arne

“…The new concept of spread through air spaces (STAS) was introduced for pulmonary adenocarcinomas (ADC) in the 2015 World Health Organization (WHO)…”
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Prognostic Impact of Intra-alveolar Tumor Spread in Pulmonary Adenocarcinoma by Warth, Arne, Muley, Thomas, Kossakowski, Claudia A, Goeppert, Benjamin, Schirmacher, Peter, Dienemann, Hendrik, Weichert, Wilko

“…Tumor spread, in general, is the most important factor determining outcome in almost all malignant tumors. Lung tumors are unique with respect to potential…”
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Impact of Comorbidities on Mortality in Patients with Idiopathic Pulmonary Fibrosis by Kreuter, Michael, Ehlers-Tenenbaum, Svenja, Palmowski, Karin, Bruhwyler, Jacques, Oltmanns, Ute, Muley, Thomas, Heussel, Claus Peter, Warth, Arne, Kolb, Martin, Herth, Felix J F

“…Comorbidities significantly influence the clinical course of idiopathic pulmonary fibrosis (IPF). However, their prognostic impact is not fully understood. We…”
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The Novel Histologic International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification System of Lung Adenocarcinoma Is a Stage-Independent Predictor of Survival by WARTH, Arne, MULEY, Thomas, MEISTER, Michael, STENZINGER, Albrecht, THOMAS, Michael, SCHIRMACHER, Peter, SCHNABEL, Philipp A, BUDCZIES, Jan, HOFFMANN, Hans, WEICHERT, Wilko

“…Our aim was to analyze and validate the prognostic impact of the novel International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society…”
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Harmonized PD-L1 immunohistochemistry for pulmonary squamous-cell and adenocarcinomas by Scheel, Andreas H, Dietel, Manfred, Heukamp, Lukas C, Jöhrens, Korinna, Kirchner, Thomas, Reu, Simone, Rüschoff, Josef, Schildhaus, Hans-Ulrich, Schirmacher, Peter, Tiemann, Markus, Warth, Arne, Weichert, Wilko, Fischer, Rieke N, Wolf, Jürgen, Buettner, Reinhard

“…Immunohistochemistry of the PD-L1 protein may be predictive for anti-PD-1 and anti-PD-L1 immunotherapy in pulmonary adenocarcinoma and in clinically unselected…”
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Circulating and Tumor Myeloid-derived Suppressor Cells in Resectable Non-Small Cell Lung Cancer by Yamauchi, Yoshikane, Safi, Seyer, Blattner, Carolin, Rathinasamy, Anchana, Umansky, Ludmila, Juenger, Simone, Warth, Arne, Eichhorn, Martin, Muley, Thomas, Herth, Felix J F, Dienemann, Hendrik, Platten, Michael, Beckhove, Philipp, Utikal, Jochen, Hoffmann, Hans, Umansky, Viktor

“…Myeloid-derived suppressor cell (MDSC) expansion has been found to play a role in disease progression in patients with cancer. However, the characteristics of…”
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Prognostic impact and clinicopathological correlations of the cribriform pattern in pulmonary adenocarcinoma by Warth, Arne, Muley, Thomas, Kossakowski, Claudia, Stenzinger, Albrecht, Schirmacher, Peter, Dienemann, Hendrik, Weichert, Wilko

“…A novel classification of pulmonary adenocarcinoma (ADC) distinguishing five growth patterns has been established by the International Association for the…”
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EML4‐ALK fusion variant V3 is a high‐risk feature conferring accelerated metastatic spread, early treatment failure and worse overall survival in ALK+ non‐small cell lung cancer by Christopoulos, Petros, Endris, Volker, Bozorgmehr, Farastuk, Elsayed, Mei, Kirchner, Martina, Ristau, Jonas, Buchhalter, Ivo, Penzel, Roland, Herth, Felix J., Heussel, Claus P., Eichhorn, Martin, Muley, Thomas, Meister, Michael, Fischer, Jürgen R., Rieken, Stefan, Warth, Arne, Bischoff, Helge, Schirmacher, Peter, Stenzinger, Albrecht, Thomas, Michael

“…In order to identify anaplastic lymphoma kinase‐driven non‐small cell lung cancer (ALK+ NSCLC) patients with a worse outcome, who might require alternative…”
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The landscape of metastatic progression patterns across major human cancers by Budczies, Jan, von Winterfeld, Moritz, Klauschen, Frederick, Bockmayr, Michael, Lennerz, Jochen K, Denkert, Carsten, Wolf, Thomas, Warth, Arne, Dietel, Manfred, Anagnostopoulos, Ioannis, Weichert, Wilko, Wittschieber, Daniel, Stenzinger, Albrecht

“…The majority of patients with solid malignancies die from metastatic burden. However, our current understanding of the mechanisms and resulting patterns of…”
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Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages by Costa da Silva, Milene, Breckwoldt, Michael O, Vinchi, Francesca, Correia, Margareta P, Stojanovic, Ana, Thielmann, Carl Maximilian, Meister, Michael, Muley, Thomas, Warth, Arne, Platten, Michael, Hentze, Matthias W, Cerwenka, Adelheid, Muckenthaler, Martina U

“…Tumor-associated macrophages (TAMs) frequently help to sustain tumor growth and mediate immune suppression in the tumor microenvironment (TME). Here, we…”
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ROS1 expression and translocations in non-small-cell lung cancer: clinicopathological analysis of 1478 cases by Warth, Arne, Muley, Thomas, Dienemann, Hendrik, Goeppert, Benjamin, Stenzinger, Albrecht, Schnabel, Philipp A, Schirmacher, Peter, Penzel, Roland, Weichert, Wilko

“…Aims Molecular characterization of non‐small‐cell lung cancer (NSCLC) has revealed multiple druggable mutations for targeted therapies. Recently, chromosomal…”
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SMARCA4 and SMARCA2 Deficiency in Non-small Cell Lung Cancer: Immunohistochemical Survey of 316 Consecutive Specimens by Herpel, Esther, MD, Rieker, Ralf J., MD, Dienemann, Hendrik, MD, Muley, Thomas, PhD, Meister, Michael, PhD, Hartmann, Arndt, MD, Warth, Arne, MD, Agaimy, Abbas, MD

“…Abstract The chromatin remodeling Switch Sucrose Non-Fermentable (SWI/SNF) complex has been increasingly implicated in the pathogenesis and dedifferentiation…”
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Predictors of Survival After Operation Among Patients With Large Cell Neuroendocrine Carcinoma of the Lung by Eichhorn, Florian, MD, Dienemann, Hendrik, MD, PhD, Muley, Thomas, MD, Warth, Arne, MD, Hoffmann, Hans, MD, PhD

“…Background Large cell neuroendocrine carcinoma (LCNEC) represents a rare entity in non-small cell lung cancer, with only partially understood biology and poor…”
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FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas by Milewski, David, Balli, David, Ustiyan, Vladimir, Le, Tien, Dienemann, Hendrik, Warth, Arne, Breuhahn, Kai, Whitsett, Jeffrey A, Kalinichenko, Vladimir V, Kalin, Tanya V

“…Lung cancer remains one of the most prominent public health challenges, accounting for the highest incidence and mortality among all human cancers. While…”
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High-throughput diagnostic profiling of clinically actionable gene fusions in lung cancer by Pfarr, Nicole, Stenzinger, Albrecht, Penzel, Roland, Warth, Arne, Dienemann, Hendrik, Schirmacher, Peter, Weichert, Wilko, Endris, Volker

“…Molecular profiling of non‐small cell lung cancers (NSCLC) has a strong impact on clinical decision making and current oncological therapies. Besides detection…”
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Transbronchial cryobiopsy increases diagnostic confidence in interstitial lung disease: a prospective multicentre trial by Hetzel, Jürgen, Wells, Athol U, Costabel, Ulrich, Colby, Thomas V, Walsh, Simon L F, Verschakelen, Johny, Cavazza, Alberto, Tomassetti, Sara, Ravaglia, Claudia, Böckeler, Michael, Spengler, Werner, Kreuter, Michael, Eberhardt, Ralf, Darwiche, Kaid, Torrego, Alfons, Pajares, Virginia, Muche, Rainer, Musterle, Regina, Horger, Marius, Fend, Falko, Warth, Arne, Heußel, Claus Peter, Piciucchi, Sara, Dubini, Alessandra, Theegarten, Dirk, Franquet, Tomas, Lerma, Enrique, Poletti, Venerino, Häntschel, Maik

“…The accurate diagnosis of individual interstitial lung diseases (ILD) is often challenging, but is a critical determinant of appropriate management. If a…”
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A Novel Grading System Based on Tumor Budding and Cell Nest Size is a Strong Predictor of Patient Outcome in Esophageal Squamous Cell Carcinoma by Jesinghaus, Moritz, Boxberg, Melanie, Konukiewitz, Björn, Slotta-Huspenina, Julia, Schlitter, Anna M, Steiger, Katja, Specht, Katja, Wieczorek, Kathrin, Warth, Arne, Schmidt, Thomas, Hartmann, Arndt, Demir, Ihsan E, Feith, Markus, Ott, Katja, Weichert, Wilko

“…The determination of prognosis in patients with esophageal squamous cell carcinoma (ESCC) is primarily based on staging according to the TNM-classification,…”
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Procedure-Specific Risk Prediction for Recurrence in Patients Undergoing Lobectomy or Sublobar Resection for Small (≤2 cm) Lung Adenocarcinoma: An International Cohort Analysis by Bains, Sarina, Eguchi, Takashi, Warth, Arne, Yeh, Yi-Chen, Nitadori, Jun-Ichi, Woo, Kaitlin M, Chou, Teh-Ying, Dienemann, Hendrik, Muley, Thomas, Nakajima, Jun, Shinozaki-Ushiku, Aya, Wu, Yu-Chung, Lu, Shaohua, Kadota, Kyuichi, Jones, David R, Travis, William D, Tan, Kay See, Adusumilli, Prasad S

“…This work was performed to develop and validate procedure-specific risk prediction for recurrence following resection for early-stage lung adenocarcinoma (ADC)…”
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Global DNA methylation reflects spatial heterogeneity and molecular evolution of lung adenocarcinomas by Dietz, Steffen, Lifshitz, Aviezer, Kazdal, Daniel, Harms, Alexander, Endris, Volker, Winter, Hauke, Stenzinger, Albrecht, Warth, Arne, Sill, Martin, Tanay, Amos, Sültmann, Holger

“…Lung adenocarcinoma (ADC) is the most prevalent subtype of lung cancer and characterized by considerable morphological and mutational heterogeneity. However,…”
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Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway by Goeppert, Benjamin, Konermann, Carolin, Schmidt, Christopher Roman, Bogatyrova, Olga, Geiselhart, Lea, Ernst, Christina, Gu, Lei, Becker, Natalia, Zucknick, Manuela, Mehrabi, Arianeb, Hafezi, Mohammadreza, Klauschen, Frederick, Stenzinger, Albrecht, Warth, Arne, Breuhahn, Kai, Renner, Marcus, Weichert, Wilko, Schirmacher, Peter, Plass, Christoph, Weichenhan, Dieter

“…The molecular mechanisms underlying the genesis of cholangiocarcinomas (CCs) are poorly understood. Epigenetic changes such as aberrant hypermethylation and…”
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