Search Results - "Warshaw, M"

Mechanical Coupling between Myosin Molecules Causes Differences between Ensemble and Single-Molecule Measurements by Walcott, Sam, Warshaw, David M., Debold, Edward P.

“…In contracting muscle, individual myosin molecules function as part of a large ensemble, hydrolyzing ATP to power the relative sliding of actin filaments. The…”
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Understanding Cardiomyopathy Phenotypes Based on the Functional Impact of Mutations in the Myosin Motor by Moore, Jeffrey R, Leinwand, Leslie, Warshaw, David M

“…Hypertrophic (HCM) and dilated (DCM) cardiomyopathies are inherited diseases with a high incidence of death due to electric abnormalities or outflow tract…”
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Cargo transport: molecular motors navigate a complex cytoskeleton by Ross, Jennifer L, Ali, M Yusuf, Warshaw, David M

“…Intracellular cargo transport requires microtubule-based motors, kinesin and cytoplasmic dynein, and the actin-based myosin motors to maneuver through the…”
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Throttling back the heart's molecular motor by Warshaw, David M.

“…A small molecule inhibits mutated forms of myosin that cause cardiac hypertrophy [Also see Report by Green et al. ] A young athlete collapses and dies during…”
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Indoor Tanning and Risk of Melanoma: A Case-Control Study in a Highly Exposed Population by LAZOVICH, Deann, ISAKSSON VOGEL, Rachel, BERWICK, Marianne, WEINSTOCK, Martin A, ANDERSON, Kristin E, WARSAW, Erin M

“…Indoor tanning has been only weakly associated with melanoma risk; most reports were unable to adjust for sun exposure, confirm a dose-response, or examine…”
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Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism by Ji Young Mun, Previs, Michael J., Yu, Hope Y., Gulick, James, Tobacman, Larry S., Previs, Samantha Beck, Robbins, Jeffrey, Warshaw, David M., Craig, Roger

“…Myosin-binding protein C (MyBP-C) is an accessory protein of striated muscle thick filaments and a modulator of cardiac muscle contraction. Defects in the…”
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Sulfites: Allergen of the Year 2024 by Ekstein, Samuel F, Warshaw, Erin M

“…Sodium disulfite, also known as sodium metabisulfite or sodium pyrosulfite, is an inorganic compound, which may cause allergic contact dermatitis. Sulfites act…”
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Motor coupling through lipid membranes enhances transport velocities for ensembles of myosin Va by Nelson, Shane R, Trybus, Kathleen M, Warshaw, David M

“…Significance Intracellular cargo transport is carried out by ensembles of cytoskeleton-based molecular motors, such as myosin Va. Physiologically, motor…”
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Phosphorylation and calcium antagonistically tune myosin-binding protein C’s structure and function by Previs, Michael J., Mun, Ji Young, Michalek, Arthur J., Previs, Samantha Beck, Gulick, James, Robbins, Jeffrey, Warshaw, David M., Craig, Roger

“…During each heartbeat, cardiac contractility results from calcium-activated sliding of actin thin filaments toward the centers of myosin thick filaments to…”
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Two glycosylase families diffusively scan DNA using a wedge residue to probe for and identify oxidatively damaged bases by Nelson, Shane R, Dunn, Andrew R, Kathe, Scott D, Warshaw, David M, Wallace, Susan S

“…DNA glycosylases are enzymes that perform the initial steps of base excision repair, the principal repair mechanism that identifies and removes endogenous…”
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Collaborative Dynamic DNA Scanning by Nucleotide Excision Repair Proteins Investigated by Single- Molecule Imaging of Quantum-Dot-Labeled Proteins by Kad, Neil M., Wang, Hong, Kennedy, Guy G., Warshaw, David M., Van Houten, Bennett

“…How DNA repair proteins sort through a genome for damage is one of the fundamental unanswered questions in this field. To address this problem, we uniquely…”
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Myosin Va transport of liposomes in three-dimensional actin networks is modulated by actin filament density, position, and polarity by Lombardo, Andrew T., Nelson, Shane R., Kennedy, Guy G., Trybus, Kathleen M., Walcott, Sam, Warshaw, David M.

“…The cell’s dense 3D actin filament network presents numerous challenges to vesicular transport by teams of myosin Va (MyoVa) molecular motors. These teams must…”
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Molecular Mechanics of Cardiac Myosin-Binding Protein C in Native Thick Filaments by Previs, M. J., Previs, S. Beck, Gulick, J., Robbins, J., Warshaw, D. M.

“…The heart's pumping capacity results from highly regulated interactions of actomyosin molecular motors. Mutations in the gene for a potential regulator of…”
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A circular zone of attachment to the extracellular matrix provides directionality to the motility of Toxoplasma gondii in 3D by Stadler, Rachel V, Nelson, Shane R, Warshaw, David M, Ward, Gary E

“…is a protozoan parasite that infects 30-40% of the world's population. Infections are typically subclinical but can be severe and, in some cases, life…”
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Teledermatology for diagnosis and management of skin conditions: A systematic review by Warshaw, Erin M., MD, MS, Hillman, Yonatan J., BA, Greer, Nancy L., PhD, Hagel, Emily M., MS, MacDonald, Roderick, MS, Rutks, Indulis R., BS, Wilt, Timothy J., MD, MPH

“…Objective We performed a systematic review of the literature addressing teledermatology: (1) diagnostic accuracy/concordance; (2) management…”
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Occupational contact dermatitis: Retrospective analysis of North American Contact Dermatitis Group Data, 2001 to 2016 by DeKoven, Joel G., DeKoven, Benjamin M., Warshaw, Erin M., Mathias, C.G.T., Taylor, James S., Sasseville, Denis, Belsito, Donald V., Fowler, Joseph F., Pratt, Melanie D., Zug, Kathryn A., Maibach, Howard I., DeLeo, Vincent A., Silverberg, Jonathan I., Atwater, Amber R., Reeder, Margo J., Holness, D. Linn

“…Patch testing is an important diagnostic tool for suspected allergic contact dermatitis (ACD) in occupational settings. Provide an overview of occupational…”
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Reliability of store and forward teledermatology for skin neoplasms by Warshaw, Erin M., MD, MS, Gravely, Amy A., MA, Nelson, David B., PhD

“…Background Teledermatology may be less optimal for skin neoplasms than for rashes. Objectives We sought to determine agreement for skin neoplasms. Methods This…”
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Allergic contact dermatitis to topical antibiotics: Epidemiology, responsible allergens, and management by Gehrig, Kathryn A., MD, Warshaw, Erin M., MD, MS

“…Topical antibiotics are widely used to treat cutaneous, ocular, and otic infections. Allergic contact dermatitis to topical antibiotics is a rare but…”
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Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro by Lombardo, Andrew T., Nelson, Shane R., Ali, M. Yusuf, Kennedy, Guy G., Trybus, Kathleen M., Walcott, Sam, Warshaw, David M.

“…Intracellular cargo transport relies on myosin Va molecular motor ensembles to travel along the cell’s three-dimensional (3D) highway of actin filaments. At…”
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National Academy of Clinical Biochemistry Standards of Laboratory Practice: Recommendations for the Use of Cardiac Markers in Coronary Artery Diseases by Wu, Alan H.B, Apple, Fred S, Gibler, W. Brian, Jesse, Robert L, Warshaw, Myron M, Valdes, Roland, Jr

“…The Sixth Conference on the "Standards of Laboratory Practice Series", sponsored by the National Academy of Clinical Biochemistry (NACB), was held on August…”
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