Search Results - "Warsh, Jerry J"

Cytoprotection by lithium and valproate varies between cell types and cellular stresses by Lai, Justin S., Zhao, Chunnian, Warsh, Jerry J., Li, Peter P.

“…Despite much evidence that lithium and valproate, two commonly used mood stabilizers, exhibit neuroprotective properties against an array of insults, the…”
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Effect of oxidative stress on TRPM2 and TRPC3 channels in B lymphoblast cells in bipolar disorder by Roedding, Angela S, Gao, Andrew F, Au-Yeung, Wynne, Scarcelli, Tiffany, Li, Peter P, Warsh, Jerry J

“…Roedding AS, Gao AF, Au‐Yeung W, Scarcelli T, Li PP, Warsh JJ. Effect of oxidative stress on TRPM2 and TRPC3 channels in B lymphoblast cells in bipolar…”
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Increased bcl-2 Protein Levels in Rat Primary Astrocyte Culture Following Chronic Lithium Treatment by Keshavarz, Mojtaba, Emamghoreishi, Masoumeh, Nekooeian, Ali Akbar, J Warsh, Jerry, Zare, Hamid Reza

“…B cell CLL/lymphoma 2 protein, bcl-2, is an important anti-apoptotic factor that has been implicated in lithium's neuroprotective effect. However, most studies…”
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TRPM2 variants and bipolar disorder risk: confirmation in a family-based association study by Xu, Chun, Li, Peter P, Cooke, Robert G, Parikh, Sagar V, Wang, KeSheng, Kennedy, James L, Warsh, Jerry J

“…Objective:  Recent case‐control studies implicate the transient receptor potential melastatin 2 (TRPM2) channel in conferring risk for bipolar disorder (BD),…”
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Inhibition of glycogen synthase kinase-3 enhances the differentiation and reduces the proliferation of adult human olfactory epithelium neural precursors by Manceur, Aziza P., Tseng, Michael, Holowacz, Tamara, Witterick, Ian, Weksberg, Rosanna, McCurdy, Richard D., Warsh, Jerry J., Audet, Julie

“…The olfactory epithelium (OE) contains neural precursor cells which can be easily harvested from a minimally invasive nasal biopsy, making them a valuable cell…”
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CACNA1C SNP rs1006737 associates with bipolar I disorder independent of the Bcl-2 SNP rs956572 variant and its associated effect on intracellular calcium homeostasis by Uemura, Takuji, Green, Marty, Warsh, Jerry J.

“…Objectives. Intracellular calcium (Ca 2+ ) dyshomeostasis (ICDH) has been implicated in bipolar disorder (BD) pathophysiology. We previously showed that SNP…”
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Chronic LiCl pretreatment suppresses thrombin-stimulated intracellular calcium mobilization through TRPC3 in astroglioma cells by Uemura, Takuji, Green, Marty, Warsh, Jerry J

“…Objectives Transient receptor potential canonical type 3 (TRPC3) channels are activated in B lymphoblast cell lines from patients with bipolar disorder (BD),…”
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Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[11C]DASB and structural brain imaging study by Kish, Stephen J., Lerch, Jason, Furukawa, Yoshiaki, Tong, Junchao, McCluskey, Tina, Wilkins, Diana, Houle, Sylvain, Meyer, Jeffrey, Mundo, Emanuela, Wilson, Alan A., Rusjan, Pablo M., Saint-Cyr, Jean A., Guttman, Mark, Collins, D. Louis, Shapiro, Colin, Warsh, Jerry J., Boileau, Isabelle

“…Animal data indicate that the recreational drug ecstasy (3,4-methylenedioxymethamphetamine) can damage brain serotonin neurons. However, human neuroimaging…”
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Impaired Endoplasmic Reticulum Stress Response in B-Lymphoblasts From Patients With Bipolar-I Disorder by So, Jonathan, Warsh, Jerry J, Li, Peter P

“…Backgroud Aberrant intracellular calcium (Ca2+ ) signaling in patients with bipolar-I disorder (BD-I) suggests disturbed endoplasmic reticulum (ER) function in…”
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Does sodium oxybate inhibit brain dopamine release in humans? An exploratory neuroimaging study by Kish, Stephen J, O'Leary, Gerald, Mamelak, Mortimer, McCluskey, Tina, Warsh, Jerry J, Shapiro, Colin, Bies, Robert, Yu, Yifan, Pollock, Bruce, Tong, Junchao, Boileau, Isabelle

“…Objective To establish in an exploratory neuroimaging study whether γ‐hydroxybutyrate (sodium oxybate [SO]), a sedative, anti‐narcoleptic drug with abuse…”
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Elevated serotonin transporter binding in depressed patients with Parkinson's disease: A preliminary PET study with [11C]DASB by Boileau, Isabelle, Warsh, Jerry J., Guttman, Mark, Saint-Cyr, Jean A., McCluskey, Tina, Rusjan, Pablo, Houle, Sylvain, Wilson, Alan A., Meyer, Jeffrey H., Kish, Stephen J.

“…This study investigated whether abnormalities in serotonin transporter binding occur in Parkinson's disease (PD) patients with concurrent depression. We…”
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Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder by Uemura, Takuji, Green, Marty, Corson, Timothy W, Perova, Tatiana, Li, Peter P, Warsh, Jerry J

“…Uemura T, Green M, Corson TW, Perova T, Li PP, Warsh JJ. Bcl‐2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder…”
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Differential cardiovascular and hypothalamic pituitary response to amphetamine in male pathological gamblers versus healthy controls by Zack, Martin, Boileau, Isabelle, Payer, Doris, Chugani, Bindiya, Lobo, Daniela S, Houle, Sylvain, Wilson, Alan A, Warsh, Jerry J, Kish, Stephen J

“…Cardiovascular and hypothalamic pituitary axis (HPA) disturbances have been observed in individuals who are pathological gamblers (PGs). These may partly…”
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Hyperactive intracellular calcium dynamics in B lymphoblasts from patients with bipolar I disorder by Perova, Tatiana, Wasserman, Michael J., Li, Peter P., Warsh, Jerry J.

“…Substantial evidence implicates abnormalities of intracellular calcium (Ca2+) dynamics in the pathophysiology of bipolar disorder (BD). However, the precise…”
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Differential modulation of intracellular Ca2+ responses in B lymphoblasts by mood stabilizers by Perova, Tatiana, Kwan, Melodie, Li, Peter P., Warsh, Jerry J.

“…Irregularities of intracellular calcium (Ca2+) homeostasis have been implicated in the pathophysiology of bipolar disorder (BD). Findings that chronic ex-vivo…”
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Parent of origin effect and allelic expression imbalance of the serotonin transporter in bipolar disorder and suicidal behaviour by Pinto, Crystal, Souza, Renan P., Lioult, Diane, Semeralul, Mawahib, Kennedy, James L., Warsh, Jerry J., Wong, Albert H., De Luca, Vincenzo

“…Suicide and suicidal behaviour are a major health concern worldwide particularly in patients with mood disorders. Family, adoption and twin studies show that…”
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Association of the iPLA2β gene with bipolar disorder and assessment of its interaction with TRPM2 gene polymorphisms by Xu, Chun, Warsh, Jerry J, Wang, Keng S, Mao, Chun X, Kennedy, James L

“…Altered intracellular calcium homeostasis and oxidative stress are involved in the pathophysiology of bipolar disorder (BD)-I. To explore the genes…”
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The Human Nucleus Accumbens Is Highly Susceptible to G Protein Down‐Regulation by Methamphetamine and Heroin by McLeman, Elizabeth R., Warsh, Jerry J., Ang, Lee, Li, Peter P., Kalasinsky, Kathleen S., Ross, Brian M., Tong, Junchao, Schmunk, Gregory, Adams, Vernard, Kish, Stephen J.

“…: Although the nucleus accumbens is assumed to be a critical brain “pleasure center,” its function in humans is unknown. As animal data suggest that a unique…”
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Serum calcium-independent phospholipase A2 activity in bipolar affective disorder by Ross, Brian M, Hughes, Bronwen, Kish, Stephen J, Warsh, Jerry J

“…Objective:  Phospholipases A2 (PLA2) are a family of enzymes involved in membrane phospholipid metabolism and cell signalling. The gene encoding one form, type…”
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Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder by Xu, Chun, Macciardi, Fabio, Li, Peter P., Yoon, Il-Sang, Cooke, Robert G., Hughes, Bronwen, Parikh, Sagar V., McIntyre, Roger S., Kennedy, James L., Warsh, Jerry J.

“…Disturbed intracellular calcium (Ca2+) homeostasis has been implicated in bipolar disorder (BD). Reduced mRNA levels of the transient receptor potential Ca2+…”
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