Search Results - "Warren, Noelle"
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Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders
Published in Journal of medicinal chemistry (09-03-2017)“…A series of potent and selective [1,2,4]triazolo[1,5-a]pyrimidine PDE2a inhibitors is reported. The design and improvement of the binding properties of this…”
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A Critical Evaluation of a Nicotine Vaccine within a Self-Administration Behavioral Model
Published in Molecular pharmaceutics (05-04-2010)“…(S)-Nicotine is a psychostimulant legal drug responsible for causing addiction to tobacco smoking. Tobacco smoking has been irrevocably linked to a number of…”
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Target Engagement of a Phosphodiesterase 2A Inhibitor Affecting Long-Term Memory in the Rat
Published in The Journal of pharmacology and experimental therapeutics (01-09-2019)“…Inhibition of phosphodiesterase 2A (PDE2A) has been proposed as a potential approach to enhance cognitive functioning and memory through boosting intracellular…”
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The Behavioral Profile of the Potent and Selective mGlu5 Receptor Antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in Rodent Models of Anxiety
Published in Neuropsychopharmacology (01-11-2004)“…Previous reports have demonstrated the anxiolytic effect of the potent and systemically active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist…”
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