Search Results - "Warren, H. Shaw"

Strategies to improve drug development for sepsis by Fink, Mitchell P., Warren, H. Shaw

“…Key Points Sepsis, a common and sometimes fatal systemic illness, is triggered by microbial infection and often leads to impaired function of the lungs,…”
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Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens by Zeng, Melody Y., Cisalpino, Daniel, Varadarajan, Saranyaraajan, Hellman, Judith, Warren, H. Shaw, Cascalho, Marilia, Inohara, Naohiro, Núñez, Gabriel

“…The gut microbiota is compartmentalized in the intestinal lumen and induces local immune responses, but it remains unknown whether the gut microbiota can…”
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Resilience to Bacterial Infection: Difference between Species Could Be Due to Proteins in Serum by Warren, H. Shaw, Fitting, Catherine, Hoff, Eva, Adib-Conquy, Minou, Beasley-Topliffe, Laura, Tesini, Brenda, Liang, Xueya, Valentine, Catherine, Hellman, Judith, Hayden, Douglas, Cavaillon, Jean-Marc

“…Vertebrates vary in resistance and resilience to infectious diseases, and the mechanisms that regulate the tradeoff between these often opposing protective…”
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Mice are not men by Warren, H. Shaw, Tompkins, Ronald G., Moldawer, Lyle L., Seok, Junhee, Xu, Weihong, Mindrinos, Michael N., Maier, Ronald V., Xiao, Wenzhong, Davis, Ronald W.

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Intestinal alkaline phosphatase prevents metabolic syndrome in mice by Kaliannan, Kanakaraju, Hamarneh, Sulaiman R., Economopoulos, Konstantinos P., Alam, Sayeda Nasrin, Moaven, Omeed, Patel, Palak, Malo, Nondita S., Ray, Madhury, Abtahi, Seyed M., Muhammad, Nur, Raychowdhury, Atri, Teshager, Abeba, Mohamed, Mussa M. Rafat, Moss, Angela K., Ahmed, Rizwan, Hakimian, Shahrad, Narisawa, Sonoko, Millán, José Luis, Hohmann, Elizabeth, Warren, H. Shaw, Bhan, Atul K., Malo, Madhu S., Hodin, Richard A.

“…Metabolic syndrome comprises a cluster of related disorders that includes obesity, glucose intolerance, insulin resistance, dyslipidemia, and fatty liver…”
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Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates by Malo, Madhu S, Moaven, Omeed, Muhammad, Nur, Biswas, Brishti, Alam, Sayeda N, Economopoulos, Konstantinos P, Gul, Sarah Shireen, Hamarneh, Sulaiman R, Malo, Nondita S, Teshager, Abeba, Mohamed, Mussa M Rafat, Tao, Qingsong, Narisawa, Sonoko, Millán, José Luis, Hohmann, Elizabeth L, Warren, H Shaw, Robson, Simon C, Hodin, Richard A

“…The intestinal microbiota plays a pivotal role in maintaining human health and well-being. Previously, we have shown that mice deficient in the brush-border…”
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Myocardial Ischemia Activates an Injurious Innate Immune Signaling via Cardiac Heat Shock Protein 60 and Toll-like Receptor 4 by Li, Yan, Si, Rui, Feng, Yan, Chen, Howard H., Zou, Lin, Wang, E., Zhang, Ming, Warren, H. Shaw, Sosnovik, David E., Chao, Wei

“…Innate immune response after transient ischemia is the most common cause of myocardial inflammation and may contribute to injury, yet the detailed signaling…”
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Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red Cells by Graw, Jan A, Mayeur, Claire, Rosales, Ivy, Liu, Yumin, Sabbisetti, Venkata S, Riley, Frank E, Rechester, Osher, Malhotra, Rajeev, Warren, H Shaw, Colvin, Robert B, Bonventre, Joseph V, Bloch, Donald B, Zapol, Warren M

“…BACKGROUND:Extracellular hemoglobin and cell-free heme are toxic breakdown products of hemolyzed erythrocytes. Mammals synthesize the scavenger proteins…”
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MyD88-Dependent and MyD88-Independent Pathways in Synergy, Priming, and Tolerance between TLR Agonists by Bagchi, Aranya, Herrup, Elizabeth A, Warren, H. Shaw, Trigilio, James, Shin, Hae-Sook, Valentine, Catherine, Hellman, Judith

“…TLRs sense components of microorganisms and are critical host mediators of inflammation during infection. Different TLR agonists can profoundly alter…”
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Spontaneous neutrophil migration patterns during sepsis after major burns by Jones, Caroline N, Moore, Molly, Dimisko, Laurie, Alexander, Andrew, Ibrahim, Amir, Hassell, Bryan A, Warren, H Shaw, Tompkins, Ronald G, Fagan, Shawn P, Irimia, Daniel

“…Finely tuned to respond quickly to infections, neutrophils have amazing abilities to migrate fast and efficiently towards sites of infection and inflammation…”
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Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition by Goldberg, Ross F, Austen, William G. Jr, Zhang, Xiaobo, Munene, Gitonga, Mostafa, Golam, Biswas, Shaluk, McCormack, Michael, Eberlin, Kyle R, Nguyen, John T, Tatlidede, Hamit S, Warren, H. Shaw, Narisawa, Sonoko, Millán, Jose L, Hodin, Richard A

“…Under conditions of starvation and disease, the gut barrier becomes impaired, and trophic feeding to prevent gut mucosal atrophy has become a standard…”
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Development of a Genomic Metric That Can Be Rapidly Used to Predict Clinical Outcome in Severely Injured Trauma Patients by Cuenca, Alex G, Gentile, Lori F, Lopez, M Cecilia, Ungaro, Ricardo, Liu, Huazhi, Xiao, Wenzhong, Seok, Junhee, Mindrinos, Michael N, Ang, Darwin, Baslanti, Tezcan Ozrazgat, Bihorac, Azra, Efron, Philip A, Cuschieri, Joseph, Warren, H Shaw, Tompkins, Ronald G, Maier, Ronald V, Baker, Henry V, Moldawer, Lyle L

“…OBJECTIVE:Many patients have complicated recoveries following severe trauma due to the development of organ injury. Physiological and anatomical…”
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Endothelial dysfunction inhibits the ability of haptoglobin to prevent hemoglobin-induced hypertension by Graw, Jan A, Yu, Binglan, Rezoagli, Emanuele, Warren, H Shaw, Buys, Emmanuel S, Bloch, Donald B, Zapol, Warren M

“…Intravascular hemolysis produces injury in a variety of human diseases including hemoglobinopathies, malaria, and sepsis. The adverse effects of increased…”
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Acute inflammatory response to endotoxin in mice and humans by Copeland, Shannon, Warren, H Shaw, Lowry, Stephen F, Calvano, Steve E, Remick, Daniel

“…Endotoxin injection has been widely used to study the acute inflammatory response. In this study, we directly compared the inflammatory responses to endotoxin…”
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Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages by Liang, Xueya, Lin, Tian, Sun, Guangjie, Beasley‐Topliffe, Laura, Cavaillon, Jean‐Marc, Warren, H. Shaw

“…The heme‐binding protein hemopexin limits TLR4 and TLR2 agonist‐induced macrophage cytokine production through a mechanism distinct from heme oxygenase‐1…”
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Hemopexin in severe inflammation and infection: mouse models and human diseases by Lin, Tian, Maita, Dayana, Thundivalappil, Sujatha R, Riley, Frank E, Hambsch, Jasmin, Van Marter, Linda J, Christou, Helen A, Berra, Lorenzo, Fagan, Shawn, Christiani, David C, Warren, H Shaw

“…Cell-free plasma hemoglobin is associated with poor outcome in patients with sepsis. Extracellular hemoglobin and secondarily released heme amplify…”
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Prevalence and Outcomes of Antimicrobial Treatment for Staphylococcus aureus Bacteremia in Outpatients with ESRD by CHAN, Kevin E, SHAW WARREN, H, THADHANI, Ravi I, STEELE, David J. R, HYMES, Jeffrey L, MADDUX, Franklin W, HAKIM, Raymond M

“…Staphylococcus bacteremia is a common and life-threatening medical emergency, but it is treatable with appropriate antibiotic therapy. To identify…”
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Reversing Established Sepsis with Antagonists of Endogenous High-Mobility Group Box 1 by Yang, Huan, Ochani, Mahendar, Li, Jianhua, Qiang, Xiaoling, Tanovic, Mahira, Harris, Helena E., Susarla, Srinivas M., Ulloa, Luis, Wang, Hong, DiRaimo, Robert, Czura, Christopher J., Wang, Haichao, Roth, Jesse, Warren, H. Shaw, Fink, Mitchell P., Fenton, Matthew J., Andersson, Ulf, Tracey, Kevin J.

“…Despite significant advances in intensive care therapy and antibiotics, severe sepsis accounts for 9% of all deaths in the United States annually. The…”
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Synergistic Inflammation Is Induced by Blood Degradation Products with Microbial Toll-Like Receptor Agonists and Is Blocked by Hemopexin by Lin, Tian, Kwak, Young Ho, Sammy, Fatima, He, Ping, Thundivalappil, Sujatha, Sun, Guangjie, Chao, Wei, Warren, H. Shaw

“…Detection of microbial components by immune cells via Toll-like receptors (TLRs) with subsequent induction of inflammation is essential for host defense…”
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Different Bactericidal and Inflammatory Activities of Human and Mouse Blood by Lin, Tian, Moorlag, Simone J.C.F.M, Liu, Jialin, Ahmed, Mohamed Yehia Hassan, Thundivalappil, Sujatha R, Riley, Frank E, Warren, H Shaw

“…ABSTRACTWe performed side-by-side experiments to compare the behavior of four strains of Escherichia coli and one strain of Pseudomonas aeruginosa in fresh…”
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