Search Results - "Warren, Anne Y."

WHO/ISUP classification, grading and pathological staging of renal cell carcinoma: standards and controversies by Warren, Anne Y., Harrison, David

“…Purpose Pathological parameters assessed on biopsies and resection specimens have a pivotal role in the diagnosis, prognosis and management of patients with…”
Get full text

The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma by van Leenders, Geert J.L.H., van der Kwast, Theodorus H., Grignon, David J., Evans, Andrew J., Kristiansen, Glen, Kweldam, Charlotte F., Litjens, Geert, McKenney, Jesse K., Melamed, Jonathan, Mottet, Nicholas, Paner, Gladell P., Samaratunga, Hemamali, Schoots, Ivo G., Simko, Jeffry P., Tsuzuki, Toyonori, Varma, Murali, Warren, Anne Y., Wheeler, Thomas M., Williamson, Sean R., Iczkowski, Kenneth A.

“…Five years after the last prostatic carcinoma grading consensus conference of the International Society of Urological Pathology (ISUP), accrual of new data and…”
Get full text

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors by Young, Matthew D, Mitchell, Thomas J, Vieira Braga, Felipe A, Tran, Maxine G B, Stewart, Benjamin J, Ferdinand, John R, Collord, Grace, Botting, Rachel A, Popescu, Dorin-Mirel, Loudon, Kevin W, Vento-Tormo, Roser, Stephenson, Emily, Cagan, Alex, Farndon, Sarah J, Del Castillo Velasco-Herrera, Martin, Guzzo, Charlotte, Richoz, Nathan, Mamanova, Lira, Aho, Tevita, Armitage, James N, Riddick, Antony C P, Mushtaq, Imran, Farrell, Stephen, Rampling, Dyanne, Nicholson, James, Filby, Andrew, Burge, Johanna, Lisgo, Steven, Maxwell, Patrick H, Lindsay, Susan, Warren, Anne Y, Stewart, Grant D, Sebire, Neil, Coleman, Nicholas, Haniffa, Muzlifah, Teichmann, Sarah A, Clatworthy, Menna, Behjati, Sam

“…Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor…”
Get full text

The Androgen Receptor Induces a Distinct Transcriptional Program in Castration-Resistant Prostate Cancer in Man by Sharma, Naomi L., Massie, Charlie E., Ramos-Montoya, Antonio, Zecchini, Vincent, Scott, Helen E., Lamb, Alastair D., MacArthur, Stewart, Stark, Rory, Warren, Anne Y., Mills, Ian G., Neal, David E.

“…The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commonest cancer in men in the UK. We present a comprehensive…”
Get full text

MRI-derived PRECISE scores for predicting pathologically-confirmed radiological progression in prostate cancer patients on active surveillance by Caglic, Iztok, Sushentsev, Nikita, Gnanapragasam, Vincent J., Sala, Evis, Shaida, Nadeem, Koo, Brendan C., Kozlov, Vasily, Warren, Anne Y., Kastner, Christof, Barrett, Tristan

“…Objectives To assess the predictive value and correlation to pathological progression of the Prostate Cancer Radiological Estimation of Change in Sequential…”
Get full text

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue by Cooper, Colin S, Eeles, Rosalind, Wedge, David C, Van Loo, Peter, Gundem, Gunes, Alexandrov, Ludmil B, Kremeyer, Barbara, Butler, Adam, Lynch, Andrew G, Camacho, Niedzica, Massie, Charlie E, Kay, Jonathan, Luxton, Hayley J, Edwards, Sandra, Kote-Jarai, Zsofia, Dennis, Nening, Merson, Sue, Leongamornlert, Daniel, Zamora, Jorge, Corbishley, Cathy, Thomas, Sarah, Nik-Zainal, Serena, Ramakrishna, Manasa, O'Meara, Sarah, Matthews, Lucy, Clark, Jeremy, Hurst, Rachel, Mithen, Richard, Bristow, Robert G, Boutros, Paul C, Fraser, Michael, Cooke, Susanna, Raine, Keiran, Jones, David, Menzies, Andrew, Stebbings, Lucy, Hinton, Jon, Teague, Jon, McLaren, Stuart, Mudie, Laura, Hardy, Claire, Anderson, Elizabeth, Joseph, Olivia, Goody, Victoria, Robinson, Ben, Maddison, Mark, Gamble, Stephen, Greenman, Christopher, Berney, Dan, Hazell, Steven, Livni, Naomi, Fisher, Cyril, Ogden, Christopher, Kumar, Pardeep, Thompson, Alan, Woodhouse, Christopher, Nicol, David, Mayer, Erik, Dudderidge, Tim, Shah, Nimish C, Gnanapragasam, Vincent, Voet, Thierry, Campbell, Peter, Futreal, Andrew, Easton, Douglas, Warren, Anne Y, Foster, Christopher S, Stratton, Michael R, Whitaker, Hayley C, McDermott, Ultan, Brewer, Daniel S, Neal, David E

“…Colin Cooper and colleagues report genome-wide sequences of multiple samples of multifocal cancer and morphologically normal tissue from the prostates of three…”
Get full text

Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer by Hong, Matthew K.H., Macintyre, Geoff, Wedge, David C., Van Loo, Peter, Patel, Keval, Lunke, Sebastian, Alexandrov, Ludmil B., Sloggett, Clare, Cmero, Marek, Marass, Francesco, Tsui, Dana, Mangiola, Stefano, Lonie, Andrew, Naeem, Haroon, Sapre, Nikhil, Phal, Pramit M., Kurganovs, Natalie, Chin, Xiaowen, Kerger, Michael, Warren, Anne Y., Neal, David, Gnanapragasam, Vincent, Rosenfeld, Nitzan, Pedersen, John S., Ryan, Andrew, Haviv, Izhak, Costello, Anthony J., Corcoran, Niall M., Hovens, Christopher M.

“…Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However, how the subclonal diversity of tumours changes during metastasis and…”
Get full text

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets by Wedge, David C., Gundem, Gunes, Mitchell, Thomas, Woodcock, Dan J., Martincorena, Inigo, Ghori, Mohammed, Zamora, Jorge, Butler, Adam, Whitaker, Hayley, Kote-Jarai, Zsofia, Alexandrov, Ludmil B., Van Loo, Peter, Massie, Charlie E., Dentro, Stefan, Warren, Anne Y., Verrill, Clare, Berney, Dan M., Dennis, Nening, Merson, Sue, Hawkins, Steve, Howat, William, Lu, Yong-Jie, Lambert, Adam, Kay, Jonathan, Kremeyer, Barbara, Karaszi, Katalin, Luxton, Hayley, Camacho, Niedzica, Marsden, Luke, Edwards, Sandra, Matthews, Lucy, Bo, Valeria, Leongamornlert, Daniel, McLaren, Stuart, Ng, Anthony, Yu, Yongwei, Zhang, Hongwei, Dadaev, Tokhir, Thomas, Sarah, Easton, Douglas F., Ahmed, Mahbubl, Bancroft, Elizabeth, Fisher, Cyril, Livni, Naomi, Nicol, David, Tavaré, Simon, Gill, Pelvender, Greenman, Christopher, Khoo, Vincent, Van As, Nicholas, Kumar, Pardeep, Ogden, Christopher, Cahill, Declan, Thompson, Alan, Mayer, Erik, Rowe, Edward, Dudderidge, Tim, Gnanapragasam, Vincent, Shah, Nimish C., Raine, Keiran, Jones, David, Menzies, Andrew, Stebbings, Lucy, Teague, Jon, Hazell, Steven, Corbishley, Cathy, de Bono, Johann, Attard, Gerhardt, Isaacs, William, Visakorpi, Tapio, Fraser, Michael, Boutros, Paul C., Bristow, Robert G., Workman, Paul, Sander, Chris, Hamdy, Freddie C., Futreal, Andrew, McDermott, Ultan, Al-Lazikani, Bissan, Lynch, Andrew G., Bova, G. Steven, Foster, Christopher S., Brewer, Daniel S., Neal, David E., Cooper, Colin S., Eeles, Rosalind A.

“…Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the…”
Get full text

Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer by Asim, Mohammad, Tarish, Firas, Zecchini, Heather I., Sanjiv, Kumar, Gelali, Eleni, Massie, Charles E., Baridi, Ajoeb, Warren, Anne Y., Zhao, Wanfeng, Ogris, Christoph, McDuffus, Leigh-Anne, Mascalchi, Patrice, Shaw, Greg, Dev, Harveer, Wadhwa, Karan, Wijnhoven, Paul, Forment, Josep V., Lyons, Scott R., Lynch, Andy G., O’Neill, Cormac, Zecchini, Vincent R., Rennie, Paul S., Baniahmad, Aria, Tavaré, Simon, Mills, Ian G., Galanty, Yaron, Crosetto, Nicola, Schultz, Niklas, Neal, David, Helleday, Thomas

“…Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition…”
Get full text

Embryonal precursors of Wilms tumor by Coorens, Tim H H, Treger, Taryn D, Al-Saadi, Reem, Moore, Luiza, Tran, Maxine G B, Mitchell, Thomas J, Tugnait, Suzanne, Thevanesan, Christine, Young, Matthew D, Oliver, Thomas R W, Oostveen, Minou, Collord, Grace, Tarpey, Patrick S, Cagan, Alex, Hooks, Yvette, Brougham, Mark, Reynolds, Ben C, Barone, Giuseppe, Anderson, John, Jorgensen, Mette, Burke, G A Amos, Visser, Johannes, Nicholson, James C, Smeulders, Naima, Mushtaq, Imran, Stewart, Grant D, Campbell, Peter J, Wedge, David C, Martincorena, Iñigo, Rampling, Dyanne, Hook, Liz, Warren, Anne Y, Coleman, Nicholas, Chowdhury, Tanzina, Sebire, Neil, Drost, Jarno, Saeb-Parsy, Kourosh, Stratton, Michael R, Straathof, Karin, Pritchard-Jones, Kathy, Behjati, Sam

“…Adult cancers often arise from premalignant clonal expansions. Whether the same is true of childhood tumors has been unclear. To investigate whether Wilms…”
Get full text

Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study by Lalonde, Emilie, MSc, Ishkanian, Adrian S, MD, Sykes, Jenna, MMath, Fraser, Michael, PhD, Ross-Adams, Helen, PhD, Erho, Nicholas, MSc, Dunning, Mark J, PhD, Halim, Silvia, MSc, Lamb, Alastair D, FRCS, Moon, Nathalie C, MMath, Zafarana, Gaetano, PhD, Warren, Anne Y, FRCPath, Meng, Xianyue, MSc, Thoms, John, MD, Grzadkowski, Michal R, BMath, Berlin, Alejandro, MD, Have, Cherry L, BSc, Ramnarine, Varune R, BCS, Yao, Cindy Q, MSc, Malloff, Chad A, MSc, Lam, Lucia L, BSc, Xie, Honglei, MMath, Harding, Nicholas J, PhD, Mak, Denise Y F, PhD, Chu, Kenneth C, PhD, Chong, Lauren C, BCS, Sendorek, Dorota H, BSc, P'ng, Christine, BSc, Collins, Colin C, Prof, Squire, Jeremy A, Prof, Jurisica, Igor, Prof, Cooper, Colin, PhD, Eeles, Rosalind, Prof, Pintilie, Melania, MSc, Dal Pra, Alan, MD, Davicioni, Elai, PhD, Lam, Wan L, Prof, Milosevic, Michael, MD, Neal, David E, Prof, van der Kwast, Theodorus, Prof, Boutros, Paul C, Prof, Bristow, Robert G, Prof

“…Summary Background Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided…”
Get full text

A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma by Syafruddin, Saiful E., Rodrigues, Paulo, Vojtasova, Erika, Patel, Saroor A., Zaini, M. Nazhif, Burge, Johanna, Warren, Anne Y., Stewart, Grant D., Eisen, Tim, Bihary, Dóra, Samarajiwa, Shamith A., Vanharanta, Sakari

“…Transcriptional networks are critical for the establishment of tissue-specific cellular states in health and disease, including cancer. Yet, the…”
Get full text

Elongin C (ELOC/TCEB1)-associated von Hippel–Lindau disease by Andreou, Avgi, Yngvadottir, Bryndis, Bassaganyas, Laia, Clark, Graeme, Martin, Ezequiel, Whitworth, James, Cornish, Alex J, Houlston, Richard S, Rich, Philip, Egan, Catherine, Hodgson, Shirley V, Warren, Anne Y, Snape, Katie, Maher, Eamonn R

“…Abstract Around 95% of patients with clinical features that meet the diagnostic criteria for von Hippel–Lindau disease (VHL) have a detectable inactivating…”
Get full text

Repeatability of diffusion-weighted MRI of the prostate using whole lesion ADC values, skew and histogram analysis by Barrett, Tristan, Lawrence, Edward M., Priest, Andrew N., Warren, Anne Y., Gnanapragasam, Vincent J., Gallagher, Ferdia A., Sala, Evis

“…To investigate the repeatability of diffusion-weighted imaging parameter including ADC-derived histogram values in prostate cancer. 10 patients with prostate…”
Get full text

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer by Ju, Young Seok, Alexandrov, Ludmil B, Gerstung, Moritz, Martincorena, Inigo, Nik-Zainal, Serena, Ramakrishna, Manasa, Davies, Helen R, Papaemmanuil, Elli, Gundem, Gunes, Shlien, Adam, Bolli, Niccolo, Behjati, Sam, Tarpey, Patrick S, Nangalia, Jyoti, Massie, Charles E, Butler, Adam P, Teague, Jon W, Vassiliou, George S, Green, Anthony R, Du, Ming-Qing, Unnikrishnan, Ashwin, Pimanda, John E, Teh, Bin Tean, Munshi, Nikhil, Greaves, Mel, Vyas, Paresh, El-Naggar, Adel K, Santarius, Tom, Collins, V Peter, Grundy, Richard, Taylor, Jack A, Hayes, D Neil, Malkin, David, Foster, Christopher S, Warren, Anne Y, Whitaker, Hayley C, Brewer, Daniel, Eeles, Rosalind, Cooper, Colin, Neal, David, Visakorpi, Tapio, Isaacs, William B, Bova, G Steven, Flanagan, Adrienne M, Futreal, P Andrew, Lynch, Andy G, Chinnery, Patrick F, McDermott, Ultan, Stratton, Michael R, Campbell, Peter J

“…Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy…”
Get full text

Gene regulatory mechanisms underpinning prostate cancer susceptibility by Whitington, Thomas, Gao, Ping, Song, Wei, Ross-Adams, Helen, Lamb, Alastair D, Yang, Yuehong, Svezia, Ilaria, Klevebring, Daniel, Mills, Ian G, Karlsson, Robert, Halim, Silvia, Dunning, Mark J, Egevad, Lars, Warren, Anne Y, Neal, David E, Grönberg, Henrik, Lindberg, Johan, Wei, Gong-Hong, Wiklund, Fredrik

“…Thomas Whitington and colleagues present a detailed characterization of gene regulatory mechanisms underlying prostate cancer susceptibility. Their analysis…”
Get full text

Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer by Sushentsev, Nikita, McLean, Mary A., Warren, Anne Y., Benjamin, Arnold J. V., Brodie, Cara, Frary, Amy, Gill, Andrew B., Jones, Julia, Kaggie, Joshua D., Lamb, Benjamin W., Locke, Matthew J., Miller, Jodi L., Mills, Ian G., Priest, Andrew N., Robb, Fraser J. L., Shah, Nimish, Schulte, Rolf F., Graves, Martin J., Gnanapragasam, Vincent J., Brindle, Kevin M., Barrett, Tristan, Gallagher, Ferdia A.

“…Hyperpolarised magnetic resonance imaging (HP  13 C-MRI) is an emerging clinical technique to detect [1- 13 C]lactate production in prostate cancer (PCa)…”
Get full text

Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression by Sciacovelli, Marco, Dugourd, Aurelien, Jimenez, Lorea Valcarcel, Yang, Ming, Nikitopoulou, Efterpi, Costa, Ana S. H., Tronci, Laura, Caraffini, Veronica, Rodrigues, Paulo, Schmidt, Christina, Ryan, Dylan Gerard, Young, Timothy, Zecchini, Vincent R., Rossi, Sabrina H., Massie, Charlie, Lohoff, Caroline, Masid, Maria, Hatzimanikatis, Vassily, Kuppe, Christoph, Von Kriegsheim, Alex, Kramann, Rafael, Gnanapragasam, Vincent, Warren, Anne Y., Stewart, Grant D., Erez, Ayelet, Vanharanta, Sakari, Saez-Rodriguez, Julio, Frezza, Christian

“…Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is…”
Get full text

Multiparametric MRI for assessment of early response to neoadjuvant sunitinib in renal cell carcinoma by Ursprung, Stephan, Priest, Andrew N, Zaccagna, Fulvio, Qian, Wendi, Machin, Andrea, Stewart, Grant D, Warren, Anne Y, Eisen, Timothy, Welsh, Sarah J, Gallagher, Ferdia A, Barrett, Tristan

“…To detect early response to sunitinib treatment in metastatic clear cell renal cancer (mRCC) using multiparametric MRI. Participants with mRCC undergoing…”
Get full text

Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging by ALLEN, Michael D, PHUONG LUONG, LATTANZIO, Laura, CHMIELEWSKA-KASSASSIR, Malgorzata, TOMLINSON, Ian, ROYLANCE, Rebecca, WHITAKER, Hayley C, WARREN, Anne Y, NEAL, David, FREZZA, Christian, BELTRAN, Luis, JONES, Louise J, HUDSON, Chantelle, CHELALA, Claude, WU, Bor-Wen, BOMALASKI, John S, JACKSON, Robert C, LU, Yong-Jie, CROOK, Tim, LEMOINE, Nicholas R, MATHER, Stephen, FOSTER, Julie, SOSABOWSKI, Jane, LEYTON, Julius, AVRIL, Norbert, LI, Chien-Feng, SZLOSAREK, Peter W, DELAGE, Barbara, GHAZALY, Essam, CUTTS, Rosalind, MING YUAN, SYED, Nelofer, LO NIGRO, Cristiana

“…Targeted therapies have yet to have significant impact on the survival of patients with bladder cancer. In this study, we focused on the urea cycle enzyme…”
Get full text