Search Results - "Warren, A.J."

261 Immunohistochemically detected p53 overexpression in bone marrow trephine biopsies discriminates del(5q) from other cytogenetic subtypes of myelodysplastic syndrome by Trim, N.L, Murphy, T, Warren, A.J, Erber, W.N

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The Mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis by Dobson, C.L., Warren, A.J., Pannell, R., Forster, A., Lavenir, I., Corral, J., Smith, A.J.H., Rabbitts, T.H.

“…The MLL gene from human chromosome 11q23 is involved in >30 different chromosomal translocations resulting in a plethora of different MLL fusion proteins. Each…”
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1 A mouse model highlights a role for p53 in 5q− syndrome by Barlow, J.L, Drynan, L.F, Trim, N.L, Hewett, D.R, Holmes, L.R, Lorenzo-Abalde, S, Lane, A.L, John, H.E, Pannell, R, Wong, S.H, Warren, A.J, Erber, W.N, Wainscoat, J.S, Boultwood, J, McKenzie, A.N

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38 Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome by Finch, A.J, Hilcenko, C, Basse, N, Drynan, L, Goyenechea, B, Menne, T.F, Fernández, Á. González, Simpson, P, D'Santos, C.S, Arends, M.J, Donadieu, J, Bellanné-Chantelot, C, Costanzo, M, Boone, C, McKenzie, A.N, Freund, S.M, Warren, A.J

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Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts by Papaemmanuil, E, Cazzola, M, Boultwood, J, Malcovati, L, Vyas, P, Bowen, D, Pellagatti, A, Wainscoat, J.S, Hellstrom-Lindberg, E, Gambacorti-Passerini, C, Godfrey, A.L, Rapado, I, Cvejic, A, Rance, R, McGee, C, Ellis, P, Mudie, L.J, Stephens, P.J, McLaren, S, Massie, C.E, Tarpey, P.S, Varela, I, Nik-Zainal, S, Davies, H.R, Shlien, A, Jones, D, Raine, K, Hinton, J, Butler, A.P, Teague, J.W, Baxter, E.J, Score, J, Galli, A, Della Porta, M.G, Travaglino, E, Groves, M, Tauro, S, Munshi, N.C, Anderson, K.C, El-Naggar, A, Fischer, A, Mustonen, V, Warren, A.J, Cross, N.C.P, Green, A.R, Futreal, P.A, Stratton, M.R, Campbell, P.J

“…Abnormalities in a gene encoding a messenger RNA splicing enzyme were found in nearly two thirds of patients with myelodysplastic syndromes characterized by…”
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Structural and functional analysis of a bacterial cellulase by proteolysis by Gilkes, N R, Kilburn, D G, Miller, R C, Warren, R A

“…CenA is an endo-β 1,4-glucanase from the cellulolytic bacterium Cellulomonas fimi. It is a bifunctional enzyme comprising an amino-terminal cellulose-binding…”
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RNA expression profiling reveals alterations in lipid metabolism-related molecules in response to antipsychotic drug treatment: Insights into the pathophysiology of psychiatric disorders by Thomas, E.A., Warren, A.J., Lo, D., Sutcliffe, J.G.

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The Hox11 gene is essential for cell survival during spleen development by Dear, T N, Colledge, W H, Carlton, M B, Lavenir, I, Larson, T, Smith, A J, Warren, A J, Evans, M J, Sofroniew, M V, Rabbitts, T H

“…The HOX11 homeobox gene was identified via the translocation t(10;14) in T cell leukaemia. To determine the function of this gene in mice, null mutations were…”
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A scheme for designating enzymes that hydrolyse the polysaccharides in the cell walls of plants by Henrissat, B, Teeri, T.T, Warren, R.A.J

“…A scheme is proposed for designating enzymes that hydrolyse the polysaccharides in the cell walls of plants. These enzymes are predominantly β-1,4-glycanases…”
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Characterization of a β‐N‐acetylhexosaminidase and a β‐N‐acetylglucosaminidase/β‐glucosidase from Cellulomonas fimi by Mayer, Christoph, Vocadlo, David J., Mah, Melanie, Rupitz, Karen, Stoll, Dominik, Warren, R. A. J., Withers, Stephen G.

“…The Gram‐positive soil bacterium Cellulomonas fimi is shown to produce at least two intracellular β‐N‐acetylglucosaminidases, a family 20…”
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MICROBIAL HYDROLYSIS OF POLYSACCHARIDES by Warren, R. A. J

“…Microorganisms are efficient degraders of starch, chitin, and the polysaccharides in plant cell walls. Attempts to purify hydrolases led to the realization…”
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Domains in microbial β-1,4-glycanases : sequence conservation, function, and enzyme families by GILKES, N. R, HENRISSAT, B, KILBURN, D. G, MILLER, R. C, WARREN, R. A. J

“…Several types of domain occur in beta-1, 4-glycanases. The best characterized of these are the catalytic domains and the cellulose-binding domains. The domains…”
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Changing Enzymic Reaction Mechanisms by Mutagenesis: Conversion of a Retaining Glucosidase to an Inverting Enzyme by Wang, Qingping, Graham, R. W, Trimbur, D, Warren, R. A. J, Withers, S. G

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Identification of the Acid/Base Catalyst in Agrobacterium faecalis .beta.-Glucosidase by Kinetic Analysis of Mutants by Wang, Q, Trimbur, D, Graham, R, Warren, R. A. J, Withers, S. G

“…The catalytic mechanism of the retaining beta-glucosidase (Abg) from Agrobacterium faecalis involves a double-displacement process in which an…”
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Enzymatic Synthesis of Carbon−Fluorine Bonds by Zechel, David L, Reid, Stephen P, Nashiru, Oyekanmi, Mayer, Christoph, Stoll, Dominik, Jakeman, David L, Warren, R. Antony J, Withers, Stephen G

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Glycosylation by Pichia pastoris decreases the affinity of a family 2a carbohydrate-binding module from Cellulomonas fimi: a functional and mutational analysis by Boraston, A B, Warren, R A, Kilburn, D G

“…When produced by Pichia pastoris, three of the five Asn-Xaa-Ser/Thr sequences (corresponding to Asn-24, Asn-73 and Asn-87) in the carbohydrate-binding module…”
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β-1,3-Glucan Binding by a Thermostable Carbohydrate-Binding Module from Thermotoga maritima by Boraston, Alisdair B, Warren, R. Antony J, Kilburn, Douglas G

“…The C-terminal 155 amino acids of the putative laminarinase, Lam16A, from T. maritima comprise a highly thermostable family 4 CBM that binds β-1,3- and…”
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Specificity and Affinity of Substrate Binding by a Family 17 Carbohydrate-Binding Module from Clostridium cellulovorans Cellulase 5A by Boraston, Alisdair B, Chiu, Patrick, Warren, R. Antony J, Kilburn, Douglas G

“…The C-terminal carbohydrate-binding module (CBM17) from Clostridium cellulovorans cellulase 5A is a β-1,4-glucan binding module with a preference for soluble…”
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Identification of Glu-519 as the catalytic nucleophile in beta-mannosidase 2A from Cellulomonas fimi by Stoll, D, He, S, Withers, S G, Warren, R A

“…Incubation of the beta-mannosidase Man2A from Cellulomonas fimi with 2-deoxy-2-fluoro-beta-D-mannosyl fluoride (2FMan beta F) resulted in time-dependent…”
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Genetic and morphological study of aggregation in the cellular slime mold Polyspondylium violaceum [Fungi] by Warren A.J, Warren W.D, Cox E.C

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