Search Results - "Warnock, Geoffrey"
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Microvascular dysfunction and sympathetic hyperactivity in women with supra-normal left ventricular ejection fraction (snLVEF)
Published in European journal of nuclear medicine and molecular imaging (01-12-2020)“…Background Recently, a new disease phenotype characterized by supra-normal left ventricular ejection fraction (snLVEF) has been suggested, based on large…”
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Assessment of cholesterol homeostasis in the living human brain
Published in Science translational medicine (05-10-2022)“…Alterations in brain cholesterol homeostasis have been broadly implicated in neurological disorders. Notwithstanding the complexity by which cholesterol…”
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Sex-dependent association between inflammation, neural stress responses, and impaired myocardial function
Published in European journal of nuclear medicine and molecular imaging (01-07-2020)“…Purpose Evidence to date has failed to reveal unique female determinants of cardiovascular disease. However, a strong association was recently observed between…”
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Sex Differences in the Association between Inflammation and Ischemic Heart Disease
Published in Thrombosis and haemostasis (01-09-2019)“…Inflammation plays a fundamental role in mediating all stages of atherosclerosis. Given the higher prevalence of inflammatory rheumatologic conditions in women…”
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Role of sex hormones in modulating myocardial perfusion and coronary flow reserve
Published in European journal of nuclear medicine and molecular imaging (01-06-2022)“…Background A growing body of evidence highlights sex differences in the diagnostic accuracy of cardiovascular imaging modalities. Nonetheless, the role of sex…”
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Simultaneous dynamic glucose-enhanced (DGE) MRI and fiber photometry measurements of glucose in the healthy mouse brain
Published in NeuroImage (Orlando, Fla.) (01-01-2023)“…•Fiber photometry with FRET biosensors complements MRI with cell-specific data.•Data from FRET fiber photometry are consistent with two-photon microscopy…”
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A Clinical PET Imaging Tracer ([ 18 F]DASA-23) to Monitor Pyruvate Kinase M2-Induced Glycolytic Reprogramming in Glioblastoma
Published in Clinical cancer research (01-12-2021)“…Pyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, a key process of cancer metabolism. PKM2 is preferentially expressed by glioblastoma (GBM)…”
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Evaluation of Atlas-Based Attenuation Correction for Integrated PET/MR in Human Brain: Application of a Head Atlas and Comparison to True CT-Based Attenuation Correction
Published in Journal of Nuclear Medicine (01-02-2016)“…Attenuation correction (AC) for integrated PET/MR imaging in the human brain is still an open problem. In this study, we evaluated a simplified atlas-based AC…”
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Rest/stress myocardial perfusion imaging by positron emission tomography with 18F-Flurpiridaz: A feasibility study in mice
Published in Journal of nuclear cardiology (01-02-2023)“…Myocardial perfusion imaging by positron emission tomography (PET-MPI) is the current gold standard for quantification of myocardial blood flow…”
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Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry
Published in Critical care (London, England) (29-11-2021)“…Sepsis is often associated with multiple organ failure; however, changes in brain volume with sepsis are not well understood. We assessed brain atrophy in the…”
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Quantification of perivascular inflammation does not provide incremental prognostic value over myocardial perfusion imaging and calcium scoring
Published in European journal of nuclear medicine and molecular imaging (01-06-2021)“…Aims Perivascular fat attenuation index (FAI) has emerged as a novel coronary computed tomography angiography (CCTA)–based biomarker predicting cardiovascular…”
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When SUV Matters: FDG PET/CT at Baseline Correlates with Survival in Soft Tissue and Ewing Sarcoma
Published in Life (Basel, Switzerland) (24-08-2021)“…Introduction: The role of positron-emission tomography/computed-tomography (PET/CT) in the management of sarcomas and as a prognostic tool has been studied…”
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Myocardial 18F-FDG Uptake Pattern for Cardiovascular Risk Stratification in Patients Undergoing Oncologic PET/CT
Published in Journal of clinical medicine (17-07-2020)“…Objective: Positron emission tomography/computed tomography with 18F-fluorodeoxy-glucose (18F-FDG-PET/CT) has become the standard staging modality in various…”
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Zero Echo Time MRAC on FDG-PET/MR Maintains Diagnostic Accuracy for Alzheimer's Disease; A Simulation Study Combining ADNI-Data
Published in Frontiers in neuroscience (26-11-2020)“…Attenuation correction using zero-echo time (ZTE) - magnetic resonance imaging (MRI) (ZTE-MRAC) has become one of the standard methods for brain-positron…”
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The impact of atlas-based MR attenuation correction on the diagnosis of FDG-PET/MR for Alzheimer’s diseases— A simulation study combining multi-center data and ADNI-data
Published in PloS one (03-06-2020)“…Background The purpose of this study was to assess the impact of vendor-provided atlas-based MRAC on FDG PET/MR for the evaluation of Alzheimer's disease (AD)…”
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SAFIR-I: Design and Performance of a High-Rate Preclinical PET Insert for MRI
Published in Sensors (Basel, Switzerland) (23-10-2021)“…(1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert for the Bruker BioSpec 70/30…”
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Age- and sex-dependent changes of resting amygdalar activity in individuals free of clinical cardiovascular disease
Published in Journal of nuclear cardiology (01-04-2021)“…Amygdalar metabolic activity was shown to independently predict cardiovascular outcomes. However, little is known about age- and sex-dependent variability in…”
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[11C]mHED PET follows a two-tissue compartment model in mouse myocardium with norepinephrine transporter (NET)-dependent uptake, while [18F]LMI1195 uptake is NET-independent
Published in EJNMMI research (29-09-2020)“…Purpose Clinical positron emission tomography (PET) imaging of the presynaptic norepinephrine transporter (NET) function provides valuable diagnostic…”
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Potential Impact of Statins on Neuronal Stress Responses in Patients at Risk for Cardiovascular Disease
Published in Journal of personalized medicine (01-04-2021)“…Recent studies indicate that enhanced neuronal stress responses are associated with adverse cardiovascular outcomes. A chronic inflammatory state seems to…”
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NEMA NU4-2008 Image Quality Performance Report for the microPET Focus 120 and for Various Transmission and Reconstruction Methods
Published in Journal of Nuclear Medicine (01-10-2009)“…This work aimed to evaluate the image quality and accuracy of attenuation and scatter corrections provided with the microPET Focus 120 scanner using the…”
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