Search Results - "Warnke, Stephan"

Protein Structure in the Gas Phase: The Influence of Side-Chain Microsolvation by Warnke, Stephan, von Helden, Gert, Pagel, Kevin

“…There is ongoing debate about the extent to which protein structure is retained after transfer into the gas phase. Here, using ion-mobility spectrometry, we…”
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Protomers of Benzocaine: Solvent and Permittivity Dependence by Warnke, Stephan, Seo, Jongcheol, Boschmans, Jasper, Sobott, Frank, Scrivens, James H, Bleiholder, Christian, Bowers, Michael T, Gewinner, Sandy, Schöllkopf, Wieland, Pagel, Kevin, von Helden, Gert

“…The immediate environment of a molecule can have a profound influence on its properties. Benzocaine, the ethyl ester of para-aminobenzoic acid that finds an…”
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Photodissociation of Conformer-Selected Ubiquitin Ions Reveals Site-Specific Cis/Trans Isomerization of Proline Peptide Bonds by Warnke, Stephan, Baldauf, Carsten, Bowers, Michael T, Pagel, Kevin, von Helden, Gert

“…Ultraviolet photodissociation (UVPD) of gas-phase proteins has attracted increased attention in recent years. This growing interest is largely based on the…”
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Infrared spectrum and structure of the homochiral serine octamer–dichloride complex by Seo, Jongcheol, Warnke, Stephan, Pagel, Kevin, Bowers, Michael T., von Helden, Gert

“…The amino acid serine is known to form a very stable octamer that has properties that set it apart from serine complexes of different sizes or from complexes…”
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The Structure of the Protonated Serine Octamer by Scutelnic, Valeriu, Perez, Marta A. S, Marianski, Mateusz, Warnke, Stephan, Gregor, Aurelien, Rothlisberger, Ursula, Bowers, Michael T, Baldauf, Carsten, von Helden, Gert, Rizzo, Thomas R, Seo, Jongcheol

“…The amino acid serine has long been known to form a protonated “magic-number” cluster containing eight monomer units that shows an unusually high abundance in…”
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Toward High-Throughput Cryogenic IR Fingerprinting of Mobility-Separated Glycan Isomers by Warnke, Stephan, Ben Faleh, Ahmed, Rizzo, Thomas R

“…Infrared (IR) spectroscopy is a powerful tool used to infer detailed structural information on molecules, often in conjunction with quantum-chemical…”
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How Cations Change Peptide Structure by Baldauf, Carsten, Pagel, Kevin, Warnke, Stephan, von Helden, Gert, Koksch, Beate, Blum, Volker, Scheffler, Matthias

“…Specific interactions between cations and proteins have a strong impact on peptide and protein structure. Herein, we shed light on the nature of the underlying…”
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Exploring the conformational preferences of 20-residue peptides in isolation: Ac-Ala19-Lys + H(+)vs. Ac-Lys-Ala19 + H(+) and the current reach of DFT by Schubert, Franziska, Rossi, Mariana, Baldauf, Carsten, Pagel, Kevin, Warnke, Stephan, von Helden, Gert, Filsinger, Frank, Kupser, Peter, Meijer, Gerard, Salwiczek, Mario, Koksch, Beate, Scheffler, Matthias, Blum, Volker

“…Reliable, quantitative predictions of the structure of peptides based on their amino-acid sequence information are an ongoing challenge. We here explore the…”
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Combining Ultrahigh-Resolution Ion-Mobility Spectrometry with Cryogenic Infrared Spectroscopy for the Analysis of Glycan Mixtures by Ben Faleh, Ahmed, Warnke, Stephan, Rizzo, Thomas R

“…The isomeric complexity of glycans make their analysis by traditional techniques particularly challenging. While the recent combination of ion mobility…”
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An infrared spectroscopy approach to follow β-sheet formation in peptide amyloid assemblies by Seo, Jongcheol, Hoffmann, Waldemar, Warnke, Stephan, Huang, Xing, Gewinner, Sandy, Schöllkopf, Wieland, Bowers, Michael T., von Helden, Gert, Pagel, Kevin

“…Amyloidogenic peptides and proteins play a crucial role in a variety of neurodegenerative disorders such as Alzheimer's and Parkinson's disease. These proteins…”
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Multistage Ion Mobility Spectrometry Combined with Infrared Spectroscopy for Glycan Analysis by Bansal, Priyanka, Ben Faleh, Ahmed, Warnke, Stephan, Rizzo, Thomas R.

“…The structural complexity of glycans makes their characterization challenging, not only because of the presence of various isomeric forms of the precursor…”
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Identification of N -glycan positional isomers by combining IMS and vibrational fingerprinting of structurally determinant CID fragments by Bansal, Priyanka, Ben Faleh, Ahmed, Warnke, Stephan, Rizzo, Thomas R

“…While glycans are present on the surface of cells in all living organisms and play key roles in most biological processes, their isomeric complexity makes…”
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Retention of Native Protein Structures in the Absence of Solvent: A Coupled Ion Mobility and Spectroscopic Study by Seo, Jongcheol, Hoffmann, Waldemar, Warnke, Stephan, Bowers, Michael T., Pagel, Kevin, von Helden, Gert

“…Can the structures of small to medium‐sized proteins be conserved after transfer from the solution phase to the gas phase? A large number of studies have been…”
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Separation and Identification of Glycan Anomers Using Ultrahigh-Resolution Ion-Mobility Spectrometry and Cryogenic Ion Spectroscopy by Warnke, Stephan, Ben Faleh, Ahmed, Scutelnic, Valeriu, Rizzo, Thomas R.

“…The analysis of carbohydrates, or glycans, is challenging for established structure-sensitive gas-phase methods. The multitude of possible stereo-, regio-, and…”
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Combining Liquid Chromatography and Cryogenic IR Spectroscopy in Real Time for the Analysis of Oligosaccharides by Abikhodr, Ali H., Warnke, Stephan, Ben Faleh, Ahmed, Rizzo, Thomas R.

“…While the combination of liquid chromatography (LC) and mass spectrometry (MS) serves as a robust approach for oligosaccharide analysis, it has difficulty…”
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Identification of Mobility-Resolved N‑Glycan Isomers by Ben Faleh, Ahmed, Warnke, Stephan, Bansal, Priyanka, Pellegrinelli, Robert P., Dyukova, Irina, Rizzo, Thomas R.

“…Glycan analysis has evolved considerably during the last decade. The advent of high-resolution ion-mobility spectrometry has enabled the separation of isomers…”
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How General Is Anomeric Retention during Collision-Induced Dissociation of Glycans? by Pellegrinelli, Robert P, Yue, Lei, Carrascosa, Eduardo, Warnke, Stephan, Ben Faleh, Ahmed, Rizzo, Thomas R

“…Despite the essential role that glycans play in many biological processes, their isomeric complexity makes their structural determination particularly…”
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Validated Multimethod Approach for Full Characterization of 2′-Fucosyl- d -lactose as an Industrially Produced Human Milk Oligosaccharide by Neu, Volker, Hoffmann, Waldemar, Weiß, Thomas D., Puhl, Michael, Abikhodr, Ali, Warnke, Stephan, Ben Faleh, Ahmed, Klinck, Sandra, Pommer, Maria, Kellner, Sarah, Maier, Walter

“…Human milk oligosaccharides are of high interest as active ingredients in infant formulas and dietary food supplements. Full characterization of members of…”
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New Approach for the Identification of Isobaric and Isomeric Metabolites by Ben Faleh, Ahmed, Warnke, Stephan, Van Wieringen, Teun, Abikhodr, Ali H., Rizzo, Thomas R.

“…The structural elucidation of metabolite molecules is important in many branches of the life sciences. However, the isomeric and isobaric complexity of…”
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Analyzing the higher order structure of proteins with conformer-selective ultraviolet photodissociation by Warnke, Stephan, von Helden, Gert, Pagel, Kevin

“…The top‐down approach in protein sequencing requires simple methods in which the analyte can be readily dissociated at every position along the backbone. In…”
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