Search Results - "Warner, Timothy D"

Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2 by Lucotti, Serena, Cerutti, Camilla, Soyer, Magali, Gil-Bernabé, Ana M, Gomes, Ana L, Allen, Philip D, Smart, Sean, Markelc, Bostjan, Watson, Karla, Armstrong, Paul C, Mitchell, Jane A, Warner, Timothy D, Ridley, Anne J, Muschel, Ruth J

“…Because metastasis is associated with the majority of cancer-related deaths, its prevention is a clinical aspiration. Prostanoids are a large family of…”
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Circulating MicroRNAs as Novel Biomarkers for Platelet Activation by Willeit, Peter, Zampetaki, Anna, Dudek, Katarzyna, Kaudewitz, Dorothee, King, Alice, Kirkby, Nicholas S, Crosby-Nwaobi, Roxanne, Prokopi, Marianna, Drozdov, Ignat, Langley, Sarah R, Sivaprasad, Sobha, Markus, Hugh S, Mitchell, Jane A, Warner, Timothy D, Kiechl, Stefan, Mayr, Manuel

“…RATIONALE:MicroRNA (miRNA) biomarkers are attracting considerable interest. Effects of medication, however, have not been investigated thus far. OBJECTIVE:To…”
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96-well plate-based aggregometry by Chan, Melissa V., Armstrong, Paul C., Warner, Timothy D.

“…While there are many bench and bedside tests to assess platelet reactivity, ex vivo light transmission aggregometry (LTA) remains the gold standard. LTA,…”
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What can we learn from senescent platelets, their transcriptomes and proteomes? by Allan, Harriet E., Vadgama, Ami, Armstrong, Paul C., Warner, Timothy D.

“…Research into the natural aging process of platelets has garnered much research interest in recent years, and there have long been associations drawn between…”
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Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies by Armstrong, Paul C, Hoefer, Thomas, Knowles, Rebecca B, Tucker, Arthur, Hayman, Melissa A, Ferreira, Plinio M, Chan, Melissa V, Warner, Timothy D

“…OBJECTIVE—Aspirin together with thienopyridine P2Y12 inhibitors, commonly clopidogrel, is a cornerstone of antiplatelet therapy. However, many patients…”
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COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs by Warner, Timothy D, Prof, Mitchell, Jane A, Prof

“…High doses of COX-2-selective drugs could increase the risk of thrombotic events, but in direct comparisons with traditional NSAIDs at standard doses few…”
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Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system by Kirkby, Nicholas S, Lundberg, Martina H, Harrington, Louise S, Leadbeater, Philip D. M, Milne, Ginger L, Potter, Claire M. F, Al-Yamani, Malak, Adeyemi, Oladipupo, Warner, Timothy D, Mitchell, Jane A

“…Prostacyclin is an antithrombotic hormone produced by the endothelium, whose production is dependent on cyclooxygenase (COX) enzymes of which two isoforms…”
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Cyclooxygenase-3 (COX-3): Filling in the Gaps toward a COX Continuum? by Warner, Timothy D., Mitchell, Jane A.

“…Despite the long history and widespread use of nonsteroid antiinflammatory drugs (NSAIDs), researchers still have an incomplete understanding of how the NSAIDs…”
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Blockade of the purinergic P2Y₁₂ receptor greatly increases the platelet inhibitory actions of nitric oxide by Kirkby, Nicholas S., Lundberg, Martina H., Chan, Melissa V., Vojnovic, Ivana, Solomon, Antonia B., Emerson, Michael, Mitchell, Jane A., Warner, Timothy D.

“…Circulating platelets are constantly exposed to nitric oxide (NO) released from the vascular endothelium. This NO acts to reduce platelet reactivity, and in so…”
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COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks by Kirkby, Nicholas S, Lundberg, Martina H, Wright, William R, Warner, Timothy D, Paul-Clark, Mark J, Mitchell, Jane A

“…Cyxlo-oxygenase (COX)-2 inhibitors, including traditional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with increased cardiovascular side…”
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Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry by Chan, Melissa V., Leadbeater, Philip D., Watson, Steve P., Warner, Timothy D.

“…In this short article, submitted as part of the review on platelet function testing, we illustrate the quantitative and qualitative differences between…”
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Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function by Chan, Melissa V, Hayman, Melissa A, Sivapalaratnam, Suthesh, Crescente, Marilena, Allan, Harriet E, Edin, Matthew L, Zeldin, Darryl C, Milne, Ginger L, Stephens, Jonathan, Greene, Daniel, Hanif, Moghees, O'Donnell, Valerie B, Dong, Liang, Malkowski, Michael G, Lentaigne, Claire, Wedderburn, Katherine, Stubbs, Matthew, Downes, Kate, Ouwehand, Willem H, Turro, Ernest, BioResource, Nihr, Hart, Daniel P, Freson, Kathleen, Laffan, Michael A, Warner, Timothy D

“…We have identified a rare missense variant on chromosome 9, position 125145990 (GRCh37), in exon 8 in PTGS1 (the gene encoding cyclo-oxygenase 1, COX-1, the…”
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Farnesoid X Receptor Ligands Inhibit Vascular Smooth Muscle Cell Inflammation and Migration by Li, Yoyo T.Y, Swales, Karen E, Thomas, Gareth J, Warner, Timothy D, Bishop-Bailey, David

“…OBJECTIVE—The farnesoid X receptor/bile acid receptor (FXR; NR1H4) is a ligand-activated transcription factor that regulates bile acid and lipid homeostasis,…”
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Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia by di Villa Bianca, Roberta d'Emmanuele, Mitidieri, Emma, Di Minno, Matteo N. D., Kirkby, Nicholas S., Warner, Timothy D., Di Minno, Giovanni, Cirino, Giuseppe, Sorrentino, Raffaella

“…Homocysteine is metabolized to methionine by the action of 5,10 methylenetetrahydrofolate reductase (MTHFR). Alternatively, by the transulfuration pathway,…”
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Endogenous epoxygenases are modulators of monocyte/macrophage activity by Bystrom, Jonas, Wray, Jessica A, Sugden, Mary C, Holness, Mark J, Swales, Karen E, Warner, Timothy D, Edin, Matthew L, Zeldin, Darryl C, Gilroy, Derek W, Bishop-Bailey, David

“…Arachidonic acid is metabolized through three major metabolic pathways, the cyclooxygenase, lipoxygenase and CYP450 enzyme systems. Unlike cyclooxygenase and…”
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LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression by Kirkby, Nicholas S, Zaiss, Anne K, Urquhart, Paula, Jiao, Jing, Austin, Philip J, Al-Yamani, Malak, Lundberg, Martina H, MacKenzie, Louise S, Warner, Timothy D, Nicolaou, Anna, Herschman, Harvey R, Mitchell, Jane A

“…There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have…”
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Nonsteroid Drug Selectivities for Cyclo-Oxygenase-1 Rather than Cyclo-Oxygenase-2 Are Associated with Human Gastrointestinal Toxicity: A Full in vitro Analysis by Warner, Timothy D., Giuliano, Francesco, Vojnovic, Ivana, Bukasa, Antoaneta, Mitchell, Jane A., Vane, John R.

“…The beneficial actions of nonsteroid anti-inflammatory drugs (NSAID) can be associated with inhibition of cyclo-oxygenase (COX)-2 whereas their harmful side…”
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SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet procoagulant activity by Cappelletto, Ambra, Allan, Harriet E, Crescente, Marilena, Schneider, Edoardo, Bussani, Rossana, Ali, Hashim, Secco, Ilaria, Vodret, Simone, Simeone, Roberto, Mascaretti, Luca, Zacchigna, Serena, Warner, Timothy D, Giacca, Mauro

“…Thrombosis of the lung microvasculature is a characteristic of COVID-19 disease, which is observed in large excess compared to other forms of acute respiratory…”
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Antiplatelet Actions of Statins and Fibrates Are Mediated by PPARs by ALI, Ferhana Y, ARMSTRONG, Paul C. J, DHANJI, Al-Rehan A, TUCKER, Arthur T, PAUL-CLARK, Mark J, MITCHELL, Jane A, WARNER, Timothy D

“…Statins and fibrates are hypolipidemic drugs which decrease cardiac events in individuals without raised levels of cholesterol. These drugs inhibit platelet…”
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Multiparameter phenotyping of platelets and characterization of the effects of agonists using machine learning by Vadgama, Ami, Boot, James, Dark, Nicola, Allan, Harriet E., Mein, Charles A., Armstrong, Paul C., Warner, Timothy D.

“…Platelet function is driven by the expression of specialized surface markers. The concept of distinct circulating subpopulations of platelets has emerged in…”
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