Search Results - "Warner, Kathrin"

Innate lymphoid cells in early tumor development by Warner, Kathrin, Ghaedi, Maryam, Chung, Douglas C, Jacquelot, Nicolas, Ohashi, Pamela S

“…Innate and adaptive immune cells monitor, recognize, and eliminate transformed cells. Innate lymphoid cells (ILCs) are innate counterparts of T cells that play…”
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Incomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed—Sternberg cells by Rengstl, Benjamin, Newrzela, Sebastian, Heinrich, Tim, Weiser, Christian, Thalheimer, Frederic B., Schmid, Frederike, Warner, Kathrin, Hartmann, Sylvia, Schroeder, Timm, Küppers, Ralf, Rieger, Michael A., Hansmann, Martin-Leo

“…Multinucleated Reed—Sternberg (RS) cells are pathognomonic for classical Hodgkin lymphoma (HL), and their presence is essential for diagnosis. How these giant…”
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Characterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors by Chung, Douglas C, Ghaedi, Maryam, Warner, Kathrin, Sayad, Azin, Saibil, Samuel D, Bernardini, Marcus Q, Clarke, Blaise A, Shaw, Patricia A, Butler, Marcus O, Easson, Alexandra, Morrissy, Sorana, Wang, Ben X, Nguyen, Linh, Ohashi, Pamela S, Jacquelot, Nicolas

“…The innate lymphoid cell (ILC) family is composed of heterogeneous innate effector and helper immune cells that preferentially reside in tissues where they…”
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DC-STAMP knock-down deregulates cytokine production and T-cell stimulatory capacity of LPS-matured dendritic cells by Sanecka, Anna, Ansems, Marleen, Prosser, Amy C, Danielski, Katharina, Warner, Kathrin, den Brok, Martijn H, Jansen, Bastiaan J H, Eleveld-Trancikova, Dagmar, Adema, Gosse J

“…Dendritic cells (DCs) are the highly specialized antigen presenting cells of the immune system that play a key role in regulating immune responses. DCs can…”
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ILC regulation of T cell responses in inflammatory diseases and cancer by Warner, Kathrin, Ohashi, Pamela S.

“…•Overview of ILC-T cell interactions in inflammation.•Local tissue and tumor microenvironment shape regulatory ILC functions.•Potential role for ILCs in…”
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Unique progenitors in mouse lymph node develop into CD127+ NK cells: thymus-dependent and thymus-independent pathways by Luther, Claudia, Warner, Kathrin, Takei, Fumio

“…A subset of natural killer (NK) cells in normal mouse lymph node (LN) expresses CD127 (IL-7 receptor-α chain) and is thought to derive from the thymus…”
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Innate Lymphoid Cells: Role in Immune Regulation and Cancer by Chung, Douglas C, Jacquelot, Nicolas, Ghaedi, Maryam, Warner, Kathrin, Ohashi, Pamela S

“…Immune regulation is composed of a complex network of cellular and molecular pathways that regulate the immune system and prevent tissue damage. It is…”
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The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL by Stachelscheid, Johanna, Jiang, Qu, Aszyk, Christoph, Warner, Kathrin, Bley, Nadine, Müller, Tony, Vydzhak, Olga, Symeonidis, Konstantinos, Crispatzu, Giuliano, Mayer, Petra, Blakemore, Stuart James, Goehring, Gudrun, Newrzela, Sebastian, Hippler, Stephanie, Robrecht, Sandra, Kreuzer, Karl-Anton, Pallasch, Christian, Krüger, Marcus, Lechner, Axel, Fischer, Kirsten, Stilgenbauer, Stephan, Beutner, Dirk, Hallek, Michael, Auguin, Daniel, Hüttelmaier, Stefan, Bloehdorn, Johannes, Vasyutina, Elena, Herling, Marco

“…•TCL1A directly engages CDC20 in the mitotic checkpoint complex, accelerating cell cycle transit and driving genome instability in B cells.•Downregulated CDC20…”
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A novel population of CD103-expressing CD56 +regulatory ILCs suppresses intratumoural T cells and are associated with poor prognosis in patients with ovarian carcinoma by Chung, Douglas, Vakharia, Jehan, Warner, Kathrin, Jacquelot, Nicolas, Sayad, Azin, Han, SeongJun, Ghaedi, Maryam, Garcia-Batres, Carlos, Elford, Alisha R, Matthews, Jessica A, Wang, Ben X, Nguyen, Linh T, Shaw, Patricia A, Clarke, Blaise A, Bernardini, Marcus Q, Ferguson, Sarah E, Crome, Sarah Q, Ohashi, Pamela S

“…Abstract Regulatory innate lymphoid cells (ILCregs) are an emerging family of immunoregulatory cells that suppress innate and adaptive immunity in the context…”
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Immune Checkpoints and Innate Lymphoid Cells-New Avenues for Cancer Immunotherapy by Jacquelot, Nicolas, Ghaedi, Maryam, Warner, Kathrin, Chung, Douglas C, Crome, Sarah Q, Ohashi, Pamela S

“…Immune checkpoints (IC) are broadly characterized as inhibitory pathways that tightly regulate the activation of the immune system. These molecular "brakes"…”
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Rational design and identification of immuno-oncology drug combinations by Iafolla, Marco A.J., Selby, Heather, Warner, Kathrin, Ohashi, Pamela S., Haibe-Kains, Benjamin, Siu, Lillian L.

“…Clinical trials investigating immuno-oncology (IO) drug combinations are largely based on empiricism or limited non-clinical evaluations. This study identified…”
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Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire by Millar, Douglas G., Yang, S. Y. Cindy, Sayad, Azin, Zhao, Qingchuan, Nguyen, Linh T., Warner, Kathrin, Sangster, Ami G., Nakatsugawa, Munehide, Murata, Kenji, Wang, Ben X., Shaw, Patricia, Clarke, Blaise, Bernardini, Marcus Q., Pugh, Trevor, Thibault, Pierre, Hirano, Naoto, Perreault, Claude, Ohashi, Pamela S.

“…Immunotherapeutic strategies aimed at enhancing tumor cell killing by tumor-specific T cells hold great potential for reducing tumor burden and prolonging…”
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Lymphoid progenitors in normal mouse lymph nodes develop into NK cells and T cells in vitro and in vivo by Warner, Kathrin, Luther, Claudia, Takei, Fumio

“…We have identified a population of normal mouse LN cells, termed LN lymphoid progenitor (LNLP), resembling common lymphoid progenitor (CLP) in the bone marrow…”
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Mature T-cell Lymphomagenesis Induced by Retroviral Insertional Activation of Janus Kinase 1 by Heinrich, Tim, Rengstl, Benjamin, Muik, Alexander, Petkova, Mina, Schmid, Frederike, Wistinghausen, Robin, Warner, Kathrin, Crispatzu, Giuliano, Hansmann, Martin-Leo, Herling, Marco, von Laer, Dorothee, Newrzela, Sebastian

“…Retroviral vectors (RVs) are powerful tools in clinical gene therapy. However, stable genomic integration of RVs can be oncogenic, as reported in several…”
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Unique progenitors in mouse lymph node develop into CD127+ NK cells: thymus-dependent and thymus-independent pathways by LUTHER, Claudia, WARNER, Kathrin, TAKEI, Fumio

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Models for mature T-cell lymphomas—A critical appraisal of experimental systems and their contribution to current T-cell tumorigenic concepts by Warner, Kathrin, Crispatzu, Giuliano, Al-Ghaili, Nabil, Weit, Nicole, Florou, Vaia, You, M. James, Newrzela, Sebastian, Herling, Marco

“…Abstract Mature T-cell lymphomas/leukemias (MTCL) have been understudied lymphoid neoplasms that currently receive growing attention. Our historically…”
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T-Cell Receptor Signaling in Peripheral T-Cell Lymphoma – A Review of Patterns of Alterations in a Central Growth Regulatory Pathway by Warner, Kathrin, Weit, Nicole, Crispatzu, Giuliano, Admirand, Joan, Jones, Dan, Herling, Marco

“…T-cell receptor (TCR) signaling is pivotal in T-cell development and function. In peripheral T-cell lymphomas/leukemias (PTCL/L), histogenesis, transforming…”
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Abstract 370: T-PLL cells resemble memory-type T-cells with aberrant effector functions implicating a leukemogenic cooperation of TCL1A and TCR signaling by Schrader, Alexandra, Warner, Kathrin, Oberbeck, Sebastian, Crispatzu, Giuliano, Mayer, Petra, Pützer, Sabine, Diebner, Hans, Stilgenbauer, Stephan, Hopfinger, Georg, Dürig, Jan, Haferlach, Torsten, Lanasa, Mark, Roeder, Ingo, Hallek, Michael, Mougiakakos, Dimitrios, Bergwelt-Baildon, Michael von, Brüggemann, Monika, Newrzela, Sebastian, Abken, Hinrich, Herling, Marco

“…Abstract The pathogenesis of the rare and aggressive T-cell prolymphocytic leukemia (T-PLL) is poorly understood, which particularly applies to a mechanistic…”
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Tumor-infiltrating HLA-matched CD4+ T cells retargeted against Hodgkin and Reed-Sternberg cells by Rengstl, Benjamin, Schmid, Frederike, Weiser, Christian, Döring, Claudia, Heinrich, Tim, Warner, Kathrin, Becker, Petra S. A., Wistinghausen, Robin, Kameh-Var, Sima, Werling, Eva, Billmeier, Arne, Seidl, Christian, Hartmann, Sylvia, Abken, Hinrich, Küppers, Ralf, Hansmann, Martin-Leo, Newrzela, Sebastian

“…Hodgkin lymphoma (HL) presents with a unique histologic pattern. Pathognomonic Hodgkin and Reed-Sternberg (HRS) cells usually account for less than 1% of the…”
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Non-canonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling by Oberbeck, Sebastian, Schrader, Alexandra, Warner, Kathrin, Jungherz, Dennis, Crispatzu, Giuliano, von Jan, Jana, Chmielewski, Markus, Ianevski, Aleksandr, Diebner, Hans H, Mayer, Petra, Kondo Ados, Aichatou, Wahnschaffe, Linus, Braun, Till, Müller, Tony A, Wagle, Prerana, Bouska, Alyssa, Neumann, Tom, Pützer, Sabine, Varghese, Lesley, Pflug, Natali, Thelen, Martin, Makalowski, Jennifer, Riet, Nicole, Göx, Hedwig Julia Maria, Rappl, Gunter, Altmüller, Janine, Kotrova, Michaela, Persigehl, Thorsten, Hopfinger, Georg, Hansmann, Martin L, Schlößer, Hans, Stilgenbauer, Stephan, Dürig, Jan, Mougiakakos, Dimitrios, von Bergwelt-Baildon, Michael, Roeder, Ingo, Hartmann, Sylvia, Hallek, Michael, Moriggl, Richard H, Brüggemann, Monika, Aittokallio, Tero, Iqbal, Javeed, Newrzela, Sebastian, Abken, Hinrich, Herling, Marco

“…T-cell prolymphocytic leukemia (T-PLL) is a poor-prognostic neoplasm. Differentiation stage and immune-effector functions of the underlying tumor cell are…”
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