Search Results - "Warner, D. T."

Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll‐like receptor 4 responses in macrophages by Moreno, L, McMaster, SK, Gatheral, T, Bailey, LK, Harrington, LS, Cartwright, N, Armstrong, PCJ, Warner, TD, Paul‐Clark, M, Mitchell, JA

“…Background and purpose:  Gram‐negative bacteria contain ligands for Toll‐like receptor (TLR) 4 and nucleotide oligomerization domain (NOD) 1 receptors…”
Get full text

Sputum and plasma endothelin-1 levels in exacerbations of chronic obstructive pulmonary disease by Roland, M, Bhowmik, A, Sapsford, R J, Seemungal, T A R, Jeffries, D J, Warner, T D, Wedzicha, J A

“…BACKGROUND Endothelin (ET)-l is a bronchoconstrictor peptide produced in the airways. It has been implicated in the pathogenesis of asthma and virally mediated…”
Get full text

Cyclo‐oxygenase‐2: pharmacology, physiology, biochemistry and relevance to NSAID therapy by Mitchell, Jane A, Warner, Timothy D

“…Cyclo‐oxygenase is expressed in cells in two distinct isoforms. Cyclo‐oxygenase‐1 is present constitutively whilst cyclo‐oxygenase‐2 is expressed primarily…”
Get full text

Inhibition of platelet aggregation ex vivo is repressed in apolipoprotein E deficient mice by Carrier, É, Houde, M, Grandbois, M, Bkaily, G, Warner, T D, D'Orléans-Juste, P

“…In the present study, we assessed whether the endogenous platelet inhibitory mechanisms are altered in the early to moderate stages of the atherosclerotic…”
Get more information

An Open-Label Trial of Evidence-Based Cognitive Behavior Therapy for Nightmares and Insomnia in Crime Victims With PTSD by Krakow, Barry, Johnston, Lisa, Melendrez, Dominic, Hollifield, Michael, Warner, Teddy D., Chavez-Kennedy, Debie, Herlan, Margaret J.

“…OBJECTIVE: Insomnia and nightmares are perceived as secondary phenomena in posttraumatic stress disorder (PTSD). Scant treatment research has targeted these…”
Get full text

Purification and Characterization of Particulate Endothelium-Derived Relaxing Factor Synthase from Cultured and Native Bovine Aortic Endothelial Cells by Pollock, Jennifer S., Forstermann, Ulrich, Mitchell, Jane A., Warner, Timothy D., Harald H. H. W. Schmidt, Nakane, Masaki, Murad, Ferid

“…The particulate enzyme responsible for the synthesis of endothelium-derived relaxing factor has been purified from cultured and native (noncultured) bovine…”
Get full text

Pressor Effects of Circulating Endothelin are Limited by its Removal in the Pulmonary Circulation and by the Release of Prostacyclin and Endothelium-Derived Relaxing Factor by De Nucci, Gilberto, Thomas, Roger, D'Orleans-Juste, Pedro, Antunes, Edson, Walder, Claire, Warner, Timothy D., Vane, John R.

“…Endothelin releases prostacyclin and thromboxane A2 from guinea pig or rat isolated lungs and endothelium-derived relaxing factor in the perfused mesentery of…”
Get full text

Effects of non‐steroidal anti‐inflammatory drugs on cyclo‐oxygenase and lipoxygenase activity in whole blood from aspirin‐sensitive asthmatics vs healthy donors by Gray, P A, Warner, T D, Vojnovic, I, Del Soldato, P, Parikh, A, Scadding, G K, Mitchell, J A

“…Cyclo‐oxygenase (COX) and lipoxygenase (LO) share a common substrate, arachidonic acid. Aspirin and related drugs inhibit COX activity. In a subset of patients…”
Get full text

A controlled study of imagery rehearsal for chronic nightmares in sexual assault survivors with PTSD: A preliminary report by Krakow, Barry, Hollifield, Michael, Schrader, Ron, Koss, Mary, Tandberg, Dan, Lauriello, John, McBride, Leslie, Warner, Teddy D., Cheng, Diana, Edmond, Tonya, Kellner, Robert

“…Imagery‐rehearsal therapy for chronic nightmares was assessed in a randomized, controlled study of sexual assault survivors with posttraumatic stress disorder…”
Get full text

Ex vivo assay to determine the cyclooxygenase selectivity of non‐steroidal anti‐inflammatory drugs by Giuliano, Francesco, Warner, Timothy D

“…In this study we describe experiments to establish ex vivo the selectivity of non‐steroidal anti‐inflammatory drugs (NSAIDs) given in vivo. Anaesthetised…”
Get full text

In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation by ARMSTRONG, P. C. J., LEADBEATER, P. D., CHAN, M. V., KIRKBY, N. S., JAKUBOWSKI, J. A., MITCHELL, J. A., WARNER, T. D.

“…Background: Aspirin and antagonists of platelet ADP P2Y12 receptors are often coprescribed for protection against thrombotic events. However, blockade of…”
Get full text

Selective COX‐2 inhibitors and human inflammatory bowel disease by MCCARTNEY, S. A, MITCHELL, J. A, FAIRCLOUGH, P. D, FARTHING, M. J. G, WARNER, T. D

“…Background : Much recent effort has been made to produce selective inhibitors of cyclo‐oxygenase‐2 (COX‐2) in the belief that these will lack the…”
Get full text

Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages by Schmidt, H H, Warner, T D, Nakane, M, Förstermann, U, Murad, F

“…In nitrinergic signal transduction, nitrogen oxide (NO) synthases (NOS) (EC 1.14.23) catalyze the conversion of L-arginine to L-citrulline and NO, which in…”
Get more information

Why Neighborhoods (and How We Study Them) Matter for Adolescent Development by Warner, T D, Settersten, Jr, R A

“…Adolescence is a sensitive developmental period marked by significant changes that unfold across multiple contexts. As a central context of development,…”
Get more information

Platelet responses to pharmacological and physiological interventions in middle‐aged men with different habitual physical activity levels by Lundberg Slingsby, M. H., Gliemann, L., Thrane, M., Rytter, N., Egelund, J., Chan, M. V., Armstrong, P. C., Warner, T. D., Hellsten, Y.

“…The current guidelines following an acute coronary syndrome recommend dual‐antiplatelet therapy (DAPT) (aspirin plus a P2Y12 antagonist) alongside lifestyle…”
Get full text

Perspectives of Patients With Schizophrenia and Psychiatrists Regarding Ethically Important Aspects of Research Participation by Roberts, Laura Weiss, Warner, Teddy D., Brody, Janet L.

“…OBJECTIVE: Significant controversy surrounds the ethics of psychiatric research. Nevertheless, few data have been gathered to improve our understanding of how…”
Get full text

Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing by Ahmetaj-Shala, B., Tesfai, A., Constantinou, C., Leszczynski, R., Chan, M.V., Gashaw, H., Galaris, G., Mazi, S., Warner, T.D., Kirkby, N.S., Mitchell, J.A.

“…Nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, are amongst the most commonly used medications and produce their anti-inflammatory and…”
Get full text

Endogenously Released Endothelin-1 from Human Pulmonary Artery Smooth Muscle Promotes Cellular Proliferation . Relevance to Pathogenesis of Pulmonary Hypertension and Vascular Remodeling by Wort, Stephen J, Woods, Mandy, Warner, Timothy D, Evans, Timothy W, Mitchell, Jane A

“…Endothelin (ET)-1 is a potent vasoconstrictor and comitogen/ proliferation factor for vascular smooth muscle (VSM). As such, it has been implicated in the…”
Get full text

Nomenclature for COX-2 Inhibitors by Vane, JR, Warner, TD

“…Patrignani and colleagues' human in-vitro wholeblood assay5 has become an accepted and reproducible standard for measuring the effects of anti-inflammatory…”
Get full text

Reduction of platelet thromboxane A2 production ex vivo and in vivo by clopidogrel therapy by ARMSTRONG, P. C. J., DHANJI, A.‐R. A., TUCKER, A. T., MITCHELL, J. A., WARNER, T. D.

Get full text