Search Results - "Warmerdam, Daniël O."

Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats by Warmerdam, Daniël O., van den Berg, Jeroen, Medema, René H.

“…rDNA repeats constitute the most heavily transcribed region in the human genome. Tumors frequently display elevated levels of recombination in rDNA, indicating…”
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Reassessing human MHC-I genetic diversity in T cell studies by Slieker, Roderick C., Warmerdam, Daniël O., Vermeer, Maarten H., van Doorn, Remco, Heemskerk, Mirjam H. M., Scheeren, Ferenc A.

“…The Major Histocompatibility Complex class I (MHC-I) system plays a vital role in immune responses by presenting antigens to T cells. Allele specific…”
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PHF6 promotes non‐homologous end joining and G2 checkpoint recovery by Warmerdam, Daniël O, Alonso‐de Vega, Ignacio, Wiegant, Wouter W, van den Broek, Bram, Rother, Magdalena B, Wolthuis, Rob MF, Freire, Raimundo, van Attikum, Haico, Medema, René H, Smits, Veronique AJ

“…The cellular response to DNA breaks is influenced by chromatin compaction. To identify chromatin regulators involved in the DNA damage response, we screened…”
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Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair by Luijsterburg, Martijn S, von Bornstaedt, Gesa, Gourdin, Audrey M, Politi, Antonio Z, Moné, Martijn J, Warmerdam, Daniël O, Goedhart, Joachim, Vermeulen, Wim, van Driel, Roel, Höfer, Thomas

“…To understand how multiprotein complexes assemble and function on chromatin, we combined quantitative analysis of the mammalian nucleotide excision DNA repair…”
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Recruitment of the Nucleotide Excision Repair Endonuclease XPG to Sites of UV-Induced DNA Damage Depends on Functional TFIIH by Zotter, Angelika, Luijsterburg, Martijn S., Warmerdam, Daniël O., Ibrahim, Shehu, Nigg, Alex, van Cappellen, Wiggert A., Hoeijmakers, Jan H. J., van Driel, Roel, Vermeulen, Wim, Houtsmuller, Adriaan B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Apc-mutant cells act as supercompetitors in intestinal tumour initiation by van Neerven, Sanne M., de Groot, Nina E., Nijman, Lisanne E., Scicluna, Brendon P., van Driel, Milou S., Lecca, Maria C., Warmerdam, Daniël O., Kakkar, Vaishali, Moreno, Leandro F., Vieira Braga, Felipe A., Sanches, Delano R., Ramesh, Prashanthi, ten Hoorn, Sanne, Aelvoet, Arthur S., van Boxel, Marouska F., Koens, Lianne, Krawczyk, Przemek M., Koster, Jan, Dekker, Evelien, Medema, Jan Paul, Winton, Douglas J., Bijlsma, Maarten F., Morrissey, Edward, Léveillé, Nicolas, Vermeulen, Louis

“…A delicate equilibrium of WNT agonists and antagonists in the intestinal stem cell (ISC) niche is critical to maintaining the ISC compartment, as it…”
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UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway by Warmerdam, Daniël O, Brinkman, Eva K, Marteijn, Jurgen A, Medema, René H, Kanaar, Roland, Smits, Veronique A J

“…In response to UV light, single-stranded DNA intermediates coated with replication protein A (RPA) are generated, which trigger the ATR-Chk1 checkpoint…”
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Keeping ribosomal DNA intact: a repeating challenge by Warmerdam, Daniël O., Wolthuis, Rob M. F.

“…More than half of the human genome consists of repetitive sequences, with the ribosomal DNA (rDNA) representing two of the largest repeats. Repetitive rDNA…”
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The core spliceosome as target and effector of non-canonical ATM signalling by Tresini, Maria, Warmerdam, Daniël O., Kolovos, Petros, Snijder, Loes, Vrouwe, Mischa G., Demmers, Jeroen A. A., van IJcken, Wilfred F. J., Grosveld, Frank G., Medema, René H., Hoeijmakers, Jan H. J., Mullenders, Leon H. F., Vermeulen, Wim, Marteijn, Jurgen A.

“…In response to DNA damage, tissue homoeostasis is ensured by protein networks promoting DNA repair, cell cycle arrest or apoptosis. DNA damage response…”
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Chromatin regulators and their impact on DNA repair and G2 checkpoint recovery by Smits, Veronique A. J., Alonso-de Vega, Ignacio, Warmerdam, Daniël O.

“…Chromatin plays a pivotal role in regulating the DNA damage response and during DNA double-strand break repair. Upon the generation of DNA breaks, the…”
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Dealing with DNA damage: Relationships between checkpoint and repair pathways by Warmerdam, Daniël O., Kanaar, Roland

“…Cell cycle checkpoint activation and DNA repair pathways govern genomic stability after genotoxic stress. Genotoxic insult results in activation of an…”
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Heterochromatin Protein 1 Is Recruited to Various Types of DNA Damage by Luijsterburg, Martijn S., Dinant, Christoffel, Lans, Hannes, Stap, Jan, Wiernasz, Elzbieta, Lagerwerf, Saskia, Warmerdam, Daniël O., Lindh, Michael, Brink, Maartje C., Dobrucki, Jurek W., Aten, Jacob A., Fousteri, Maria I., Jansen, Gert, Dantuma, Nico P., Vermeulen, Wim, Mullenders, Leon H. F., Houtsmuller, Adriaan B., Verschure, Pernette J., van Driel, Roel

“…Heterochromatin protein 1 (HP1) family members are chromatin-associated proteins involved in transcription, replication, and chromatin organization. We show…”
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EDDiting p53 levels by Warmerdam, Daniël O.

“…Comment on: Smits VAJ. Cell Cycle 2012; 11:715-20…”
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ATR and Rad17 collaborate in modulating Rad9 localisation at sites of DNA damage by Medhurst, Annette L, Warmerdam, Daniël O, Akerman, Ildem, Verwayen, Edward H, Kanaar, Roland, Smits, Veronique A.J, Lakin, Nicholas D

“…The cell cycle checkpoint kinase Chk1 is phosphorylated and activated by ATR in response to DNA damage and is crucial for initiating the DNA damage response. A…”
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Cell cycle-dependent processing of DNA lesions controls localization of Rad9 to sites of genotoxic stress by Warmerdam, Daniël O., Freire, Raimundo, Kanaar, Roland, Smits, Veronique A.J.

“…The Rad9/Rad1/Hus1 complex functions to facilitate the ATR-mediated phosphorylation of several substrates that control the checkpoint arrest induced by DNA…”
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From DNA End Chemistry to Cell-Cycle Response: The Importance of Structure, Even When It's Broken by Wyman, Claire, Warmerdam, Daniël O., Kanaar, Roland

“…In this issue of Molecular Cell, Barlow et al. (2008) show that not all DNA double-strand breaks are processed equally and that the chemical nature of DNA ends…”
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Differential Dynamics of ATR-Mediated Checkpoint Regulators by Warmerdam, Daniël O., Kanaar, Roland, Smits, Veronique A. J.

“…The ATR-Chk1 checkpoint pathway is activated by UV-induced DNA lesions and replication stress. Little was known about the spatio and temporal behaviour of the…”
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Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation by Halim, Vincentius A., García-Santisteban, Iraia, Warmerdam, Daniel O., van den Broek, Bram, Heck, Albert J.R., Mohammed, Shabaz, Medema, René H.

“…Protein posttranslational modifications (PTMs) play a central role in the DNA damage response. In particular, protein phosphorylation and ubiquitination have…”
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Mechanisms of ATR-mediated checkpoint signalling by Smits, Veronique A J, Warmerdam, Daniel O, Martin, Yuse, Freire, Raimundo

“…Cell cycle checkpoints maintain genomic integrity by delaying cell division in the presence of DNA damage or replication problems. A crucial player in this…”
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Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma by Zomerman, Walderik W., Plasschaert, Sabine L.A., Conroy, Siobhan, Scherpen, Frank J., Meeuwsen-de Boer, Tiny G.J., Lourens, Harm J., Guerrero Llobet, Sergi, Smit, Marlinde J., Slagter-Menkema, Lorian, Seitz, Annika, Gidding, Corrie E.M., Hulleman, Esther, Wesseling, Pieter, Meijer, Lisethe, van Kempen, Leon C., van den Berg, Anke, Warmerdam, Daniël O., Kruyt, Frank A.E., Foijer, Floris, van Vugt, Marcel A.T.M., den Dunnen, Wilfred F.A., Hoving, Eelco W., Guryev, Victor, de Bont, Eveline S.J.M., Bruggeman, Sophia W.M.

“…The brain cancer medulloblastoma consists of different transcriptional subgroups. To characterize medulloblastoma at the phosphoprotein-signaling level, we…”
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