Search Results - "Wark, Peter AB"

Aim2 suppresses cigarette smoke‐induced neutrophil recruitment, neutrophil caspase‐1 activation and anti‐Ly6G‐mediated neutrophil depletion by Donovan, Chantal, Kim, Richard Y, Galvao, Izabela, Jarnicki, Andrew G, Brown, Alexandra C, Jones‐Freeman, Bernadette, Gomez, Henry M, Wadhwa, Ridhima, Hortle, Elinor, Jayaraman, Ranjith, Khan, Haroon, Pickles, Sophie, Sahu, Priyanka, Chimankar, Vrushali, Tu, Xiaofan, Ali, Md Khadem, Mayall, Jemma R, Nguyen, Duc H, Budden, Kurtis F, Kumar, Vinod, Schroder, Kate, Robertson, Avril AB, Cooper, Matthew A, Wark, Peter AB, Oliver, Brian G, Horvat, Jay C, Hansbro, Philip M

“…Increased inflammasome responses are strongly implicated in inflammatory diseases; however, their specific roles are incompletely understood. Therefore, we…”
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An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype by Fricker, Michael, Qin, Ling, Sánchez‐Ovando, Stephany, Simpson, Jodie L., Baines, Katherine J., Riveros, Carlos, Scott, Hayley A., Wood, Lisa G., Wark, Peter AB, Kermani, Nazanin Z., Chung, Kian Fan, Gibson, Peter G.

“…Background Neutrophilic asthma (NA) is a clinically important asthma phenotype, the cellular and molecular basis of which is not completely understood. Airway…”
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Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD by Baines, Katherine J, Hsu, Alan C-Y, Tooze, Melinda, Gunawardhana, Lakshitha P, Gibson, Peter G, Wark, Peter A B

“…Rhinovirus (RV) is a major cause of chronic obstructive pulmonary disease (COPD) exacerbations, and primarily infects bronchial epithelial cells. Immune…”
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Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production by Hu, MengJie, Schulze, Keith E, Ghildyal, Reena, Henstridge, Darren C, Kolanowski, Jacek L, New, Elizabeth J, Hong, Yuning, Hsu, Alan C, Hansbro, Philip M, Wark, Peter Ab, Bogoyevitch, Marie A, Jans, David A

“…Although respiratory syncytial virus (RSV) is responsible for more human deaths each year than influenza, its pathogenic mechanisms are poorly understood. Here…”
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RAGE: a new frontier in chronic airways disease by Sukkar, Maria B, Ullah, Md Ashik, Gan, Wan Jun, Wark, Peter AB, Chung, Kian Fan, Hughes, J Margaret, Armour, Carol L, Phipps, Simon

“…Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous inflammatory disorders of the respiratory tract characterized by airflow obstruction…”
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Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling by Kedzierski, Lukasz, Tate, Michelle D, Hsu, Alan C, Kolesnik, Tatiana B, Linossi, Edmond M, Dagley, Laura, Dong, Zhaoguang, Freeman, Sarah, Infusini, Giuseppe, Starkey, Malcolm R, Bird, Nicola L, Chatfield, Simon M, Babon, Jeffrey J, Huntington, Nicholas, Belz, Gabrielle, Webb, Andrew, Wark, Peter Ab, Nicola, Nicos A, Xu, Jianqing, Kedzierska, Katherine, Hansbro, Philip M, Nicholson, Sandra E

“…Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory…”
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Severe asthma: Current management, targeted therapies and future directions—A roundtable report by McDonald, Vanessa M., Maltby, Steven, Reddel, Helen K., King, Gregory G., Wark, Peter A.B., Smith, Lorraine, Upham, John W., James, Alan L., Marks, Guy B., Gibson, Peter G.

“…ABSTRACT Asthma is a chronic respiratory disease characterized by respiratory symptoms, airway inflammation, airway obstruction and airway…”
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Children With Asthma Have Impaired Innate Immunity and Increased Numbers of Type 2 Innate Lymphoid Cells Compared With Healthy Controls by Hosseini, Banafshe, Berthon, Bronwyn S., Starkey, Malcolm R., Collison, Adam, McLoughlin, Rebecca F., Williams, Evan J., Nichol, Kristy, Wark, Peter AB, Jensen, Megan E., Da Silva Sena, Carla Rebeca, Baines, Katherine J., Mattes, Joerg, Wood, Lisa G.

“…Background Asthma is the most frequent cause of hospitalisation among children; however, little is known regarding the effects of asthma on immune responses in…”
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Cough in Children and Adults: Diagnosis, Assessment and Management (CICADA). Summary of an updated position statement on chronic cough in Australia by Wark, Peter AB, Marchant, Julie M

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Cough in Children and Adults: Diagnosis, Assessment and Management (CICADA). Summary of an updated position statement on chronic cough in Australia by Turner, Richard, Birring, Surinder

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Appropriate use of oral corticosteroids for severe asthma by Ramsahai, J Michael, Wark, Peter AB

“…Severe asthma represents a significant burden of disease, particularly in high income nations; oral corticosteroids (OCS) remain an important part of the…”
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Cough in Children and Adults: Diagnosis, Assessment and Management (CICADA). Summary of an updated position statement on chronic cough in Australia by Marchant, Julie M, Chang, Anne B, Wark, Peter AB

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Pathophysiology of severe asthma: We’ve only just started by King, Gregory G., James, Alan, Harkness, Louise, Wark, Peter A.B.

“…ABSTRACT Severe asthma is defined by the high treatment requirements to partly or fully control the clinical manifestations of disease. It remains a problem…”
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We are not doing enough to prevent the spread of COVID‐19 and other respiratory viruses in Australian hospitals by Wark, Peter AB, MacIntyre, C Raina, Bell, Scott, Oliver, Brian, Marks, Guy B

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Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus by Wark, Peter A B, Johnston, Sebastian L, Bucchieri, Fabio, Powell, Robert, Puddicombe, Sarah, Laza-Stanca, Vasile, Holgate, Stephen T, Davies, Donna E

“…Rhinoviruses are the major trigger of acute asthma exacerbations and asthmatic subjects are more susceptible to these infections. To investigate the underlying…”
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PAT in the ER for Transmembrane Protein Folding by Pathinayake, Prabuddha S., Hsu, Alan C.-Y., Wark, Peter A.B.

“…Integral membrane proteins (IMPs) have crucial roles in many cellular processes. A novel intramembrane chaperone complex, recently elucidated by Chitwood and…”
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Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission by Wark, Peter A.B., Tooze, Melinda, Powell, Heather, Parsons, Kristy

“…Background and objective Infection is as an important trigger for acute asthma and chronic obstructive pulmonary disease (COPD). The aim of this article was to…”
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Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD by Negewo, Netsanet A, McDonald, Vanessa M, Baines, Katherine J, Wark, Peter Ab, Simpson, Jodie L, Jones, Paul W, Gibson, Peter G

“…Sputum eosinophilia occurs in approximately one-third of stable chronic obstructive pulmonary disease (COPD) patients and can predict exacerbation risk and…”
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Adjusting prednisone using blood eosinophils reduces exacerbations and improves asthma control in difficult patients with asthma by Wark, Peter AB, McDonald, Vanessa M, Gibson, Peter G

“…Severe or therapy‐resistant asthma represents a major problem, and despite advanced treatment, many patients require oral corticosteroids (OCS). We aimed to…”
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Glucocorticosteroids differentially regulate MMP-9 and neutrophil elastase in COPD by Vlahos, Ross, Wark, Peter A B, Anderson, Gary P, Bozinovski, Steven

“…Chronic Obstructive Pulmonary Disease (COPD) is currently the fifth leading cause of death worldwide. Neutrophilic inflammation is prominent, worsened during…”
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