Search Results - "Wark, L."
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Liquid Crystal Emulsions as the Basis of Biological Sensors for the Optical Detection of Bacteria and Viruses
Published in Advanced functional materials (24-07-2009)“…A versatile sensing method based on monodisperse liquid crystal (LC) emulsion droplets detects and distinguishes between different types of bacteria (Gram +ve…”
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Engineered antibody approaches for Alzheimer’s disease immunotherapy
Published in Archives of biochemistry and biophysics (15-10-2012)“…► AD is the most common form of neurodegenerative disease. ► Immunotherapy against Aβ is the most successful approach for treating AD. ► Recombinant antibodies…”
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A General Approach for DNA Encapsulation in Degradable Polymer Microcapsules
Published in ACS nano (01-08-2007)“…We report a general and facile method for the encapsulation of DNA in nanoengineered, degradable polymer microcapsules. Single-stranded (ss), linear…”
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Latest technologies for the enhancement of antibody affinity
Published in Advanced drug delivery reviews (07-08-2006)“…High affinity antibodies are crucial both for the discovery and validation of biomarkers for human health and disease and as clinical diagnostic and…”
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Metal-free and MRI visible theranostic lyotropic liquid crystal nitroxide-based nanoparticles
Published in Biomaterials (01-03-2012)“…Abstract The development of improved, low toxicity, clinically viable nanomaterials that provide MRI contrast have tremendous potential to form the basis of…”
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A Biomolecular "Ship-in-a-Bottle": Continuous RNA Synthesis Within Hollow Polymer Hydrogel Assemblies
Published in Advanced materials (Weinheim) (09-02-2010)“…The use of micrometer‐sized, monodisperse polymer hydrogel capsules that act as both microreactors and drug carriers for de novo synthesized RNA is…”
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Engineered antibody intervention strategies for Alzheimer's disease and related dementias by targeting amyloid and toxic oligomers
Published in Protein engineering, design and selection (01-03-2009)“…Most neurodegenerative disorders, such as Alzheimer's (AD), Parkinson's, Huntington's and Creutzfeldt–Jakob disease, are characterised by the accumulation of…”
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Zosteriform cutaneous metastases: an unusual presentation of metastatic lung carcinoma
Published in Respirology case reports (01-03-2020)“…Zosteriform cutaneous metastases are an unusual and rare morphological variant. We discuss the case of a 78‐year‐old gentleman with a background of end‐stage…”
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The Microbiome in Hidradenitis Suppurativa: A Review
Published in Dermatology and therapy (01-02-2021)“…Introduction Hidradenitis suppurativa (HS) is a chronic autoinflammatory skin disease. It is characterised by the development of abscesses and nodules in…”
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Characterizing the three‐dimensional organization of telomeres
Published in Cytometry. Part A (01-10-2005)“…Background Quantitative analysis can be used in combination with fluorescence microscopy. Although the human eye is able to obtain good qualitative results,…”
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Telomeric aggregates and end-to-end chromosomal fusions require myc box II
Published in Oncogene (01-03-2007)“…Telomeres of tumor cells form telomeric aggregates (TAs) within the three-dimensional (3D) interphase nucleus. Some of these TAs represent end-to-end…”
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Pregnancy-specific reference ranges for haematological variables in a Scottish population
Published in Journal of obstetrics and gynaecology (01-05-2011)“…Using laboratory reference ranges, B12 deficiency is inappropriately diagnosed and treated in pregnancy. We aim to define reference ranges for ferritin,…”
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Measurement of the Solar Neutrino Capture Rate by SAGE and Implications for Neutrino Oscillations in Vacuum
Published in Physical review letters (06-12-1999)“…The Russian-American solar neutrino experiment has measured the capture rate of neutrinos on metallic gallium in a radiochemical experiment at the Baksan…”
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Neutrino mass measurements
Published in Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences (15-11-2003)“…Before we can be sure we have a dark-matter problem we have to first be certain that no known particle can account for the missing matter. The last possibility…”
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Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery
Published in Biomacromolecules (13-12-2010)“…We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these…”
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Identification of a functional nuclear export signal in the green fluorescent protein asFP499
Published in Biochemical and biophysical research communications (21-04-2006)“…The green fluorescent protein (GFP) asFP499 from Anemonia sulcata is a distant homologue of the GFP from Aequorea victoria. We cloned the asFP499 gene into a…”
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Resident cutaneous memory T cells: a clinical review of their role in chronic inflammatory dermatoses and potential as therapeutic targets
Published in British journal of dermatology (1951) (16-11-2023)“…Abstract Resident memory T cells (T-RMs) remain in epithelial barrier tissues after antigen exposure and the initial effector phase. These T-RMs provide…”
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Germline humanization of a murine Aβ antibody and crystal structure of the humanized recombinant Fab fragment
Published in Protein science (01-02-2010)“…Alzheimer's disease is the most common form of dementia, affecting 26 million people worldwide. The Aβ peptide (39–43 amino acids) derived from the proteolytic…”
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The association between pilonidal sinus disease and hidradenitis suppurativa: a systematic review and meta-analysis
Published in British journal of dermatology (1951) (20-04-2023)“…We performed a systematic review and meta-analysis examining the association between hidradenitis suppurativa (HS) and pilonidal sinus disease (PSD). We found…”
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