Search Results - "Wargenau, Manfred"

Validating a composite endpoint for acceptability evaluation of oral drug formulations in the pediatric population: a randomized, open-label, single dose, cross-over study by Münch, Juliane, Schwarzwälder, Anna Lena, Kloft, Carolin, Bosse, Hans Martin, Wargenau, Manfred, Reidemeister, Sibylle, Klingmann, Ingrid, Klingmann, Viviane

“…This study aimed to validate the newly developed composite acceptability endpoint to investigate acceptability of oral pediatric drug formulations that…”
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Questionnaire Study to Investigate the Preferences of Children, Parents, and Healthcare Professionals for Different Formulations of Oral Medicinal Products by Wargenau, Manfred, Baase, Felicitas, Eckardt, Kristin, Spitzhorn, Lucas-Sebastian, Reidemeister, Sibylle, Klingmann, Ingrid, Klingmann, Viviane

“…Since the acceptability of a medicine can significantly impact therapeutic outcomes, this study aimed to determine and compare the preferences of children,…”
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Double‐blind, randomized, 8‐week multicenter study of the efficacy and safety of STW 5‐II versus placebo in functional dyspepsia by Vinson, Bettina, Fink, Careen, Wargenau, Manfred, Talley, Nicholas J, Holtmann, Gerald

“…Background and Aim Herbal products are widely used to treat patients with disorders of gut brain interaction but clinical efficacy and safety data for…”
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A Semi-Mechanistic Population Pharmacokinetic Model of Noscapine in Healthy Subjects Considering Hepatic First-Pass Extraction and CYP2C9 Genotypes by Chen, Zhendong, Taubert, Max, Chen, Chunli, Boland, Jana, Dong, Qian, Bilal, Muhammad, Dokos, Charalambos, Wachall, Bertil, Wargenau, Manfred, Scheidel, Bernhard, Wiesen, Martin H. J., Schaeffeler, Elke, Tremmel, Roman, Schwab, Matthias, Fuhr, Uwe

“…Introduction Noscapine is a commonly used cough suppressant, with ongoing research on its anti-inflammatory and anti-tumor properties. The drug has a…”
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Evaluating the Acceptability, Swallowability, and Palatability of Film-Coated Mini-Tablet Formulation in Young Children: Results from an Open-Label, Single-Dose, Cross-Over Study by Münch, Juliane, Sessler, Isabelle, Bosse, Hans Martin, Wargenau, Manfred, Dreesen, Janine D, Loforese, Giulio, Webb, Nicholas J A, Sivasubramanian, Rama, Reidemeister, Sibylle, Lustenberger, Philipp, Klingmann, Viviane

“…Mini-tablets are advantageous over liquid formulations in overcoming challenges related to stability, taste, and dosage. This open-label, single-dose,…”
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The Pharmacokinetics and Tolerability of an Intravenous Infusion of the New Hydroxyethyl Starch 130/0.4 (6%, 500 mL) in Mild-to-Severe Renal Impairment by Jungheinrich, Cornelius, Scharpf, Roland, Wargenau, Manfred, Bepperling, Frank, Baron, Jean-François

“…Hydroxyethyl starches (HES) are almost exclusively excreted glomerularly, in part after hydrolysis by amylase. HES 130/0.4 (Voluven®; Fresenius Kabi…”
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Pharmacokinetics and safety of 6 % hydroxyethyl starch 130/0.4 in healthy male volunteers of Japanese ethnicity after single infusion of 500 ml solution by Yamakage, Michiaki, Bepperling, Frank, Wargenau, Manfred, Miyao, Hideki

“…Purpose This phase I study was performed in volunteers of Japanese ethnicity to compare pharmacokinetic data after infusion of 6 % hydroxyethyl starch (HES)…”
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Acceptability of small-sized oblong tablets in comparison to syrup and mini-tablets in infants and toddlers: A randomized controlled trial by Münch, Juliane, Meissner, Thomas, Mayatepek, Ertan, Wargenau, Manfred, Breitkreutz, Jörg, Bosse, Hans Martin, Klingmann, Viviane

“…[Display omitted] There is limited evidence for the acceptability of various drug formulations holding the potential to improve medicines administration to…”
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330: EFFICACY AND SAFETY OF STW-5-II IN PATIENTS WITH FUNCTIONAL DYSPEPSIA: RESULTS FROM A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, 8-WEEK MULTICENTER TRIAL INCLUDING A POST-HOC ANALYSIS FOR PATIENTS MEETING FUNCTIONAL DYSPEPSIA ACCORDING TO ROME IV by Vinson, Bettina, Fink, Careen, Wargenau, Manfred, Talley, Nicholas J., Holtmann, Gerald J.

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Efficacy and Safety of STW 5-II for Functional Dyspepsia Treatment: A Patient Data-Based Meta-Analysis by Andresen, Viola, Shah, Ayesha, Fink, Careen, Rabini, Sabine, Wargenau, Manfred, Holtmann, Gerald

“…Functional dyspepsia (FD) is a chronic relapsing gastroduodenal disorder with limited treatment options. Herbal products, like the six-herb combination STW…”
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Riociguat in pulmonary hypertension and heart failure with preserved ejection fraction: the haemoDYNAMIC trial by Dachs, Theresa Marie, Duca, Franz, Rettl, René, Binder-Rodriguez, Christina, Dalos, Daniel, Ligios, Luciana Camuz, Kammerlander, Andreas, Grünig, Ekkehard, Pretsch, Ingrid, Steringer-Mascherbauer, Regina, Ablasser, Klemens, Wargenau, Manfred, Mascherbauer, Julia, Lang, Irene M, Hengstenberg, Christian, Badr-Eslam, Roza, Kastner, Johannes, Bonderman, Diana

“…Abstract Aims The presence of pulmonary hypertension (PH) severely aggravates the clinical course of heart failure with preserved ejection fraction (HFpEF). To…”
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Double-blind, randomized, 8-week multicenter study of the efficacy and safety of STW 5-IIversus placebo in functional dyspepsia by Vinson, Bettina, Fink, Careen, Wargenau, Manfred, Talley, Nicholas J, Holtmann, Gerald

“…Background and AimHerbal products are widely used to treat patients with disorders of gut brain interaction but clinical efficacy and safety data for…”
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Assessment of body mass-related covariates for rifampicin pharmacokinetics in healthy Caucasian volunteers by Bilal, Muhammad, Ullah, Sami, Jaehde, Ulrich, Trueck, Christina, Zaremba, Dario, Wachall, Bertil, Wargenau, Manfred, Scheidel, Bernhard, Wiesen, Martin H. J., Gazzaz, Malaz, Chen, Chunli, Büsker, Sören, Fuhr, Uwe, Taubert, Max, Dokos, Charalambos

“…Purpose Currently, body weight-based dosing of rifampicin is recommended. But lately, fat-free mass (FFM) was reported to be superior to body weight (BW). The…”
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Efficacy of the long-acting nitro vasodilator pentaerithrityl tetranitrate in patients with chronic stable angina pectoris receiving anti-anginal background therapy with beta-blockers: a 12-week, randomized, double-blind, placebo-controlled trial by Münzel, Thomas, Meinertz, Thomas, Tebbe, Ulrich, Schneider, Heinrich Theodor, Stalleicken, Dirk, Wargenau, Manfred, Gori, Tommaso, Klingmann, Ingrid

“…The organic nitrate pentaerithrityl tetranitrate (PETN) has been shown to have ancillary properties that prevent the development of tolerance and endothelial…”
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Evaluation of the pharmacoDYNAMIC effects of riociguat in subjects with pulmonary hypertension and heart failure with preserved ejection fraction: Study protocol for a randomized controlled trial by Mascherbauer, Julia, Grünig, Ekkehard, Halank, Michael, Hohenforst-Schmidt, Wolfgang, Kammerlander, Andreas A., Pretsch, Ingrid, Steringer-Mascherbauer, Regina, Ulrich, Silvia, Lang, Irene M., Wargenau, Manfred, Frey, Reiner, Bonderman, Diana

“…Summary Background The presence of pulmonary hypertension (PH) severely aggravates the clinical course of heart failure with preserved ejection fraction…”
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Blood glucose response after oral lactulose intake in type 2 diabetic individuals by Pieber, Thomas R, Svehlikova, Eva, Mursic, Ines, Esterl, Tamara, Wargenau, Manfred, Sartorius, Tina, Pauly, Lioba, Schwejda-Guettes, Susann, Neumann, Annalena, Faerber, Valentin, Stover, John Friedrich, Gaigg, Barbara, Kuchinka-Koch, Angelika

“…BACKGROUNDLactulose is approved for the symptomatic treatment of constipation, a gastrointestinal (GI) complication common in individuals with diabetes…”
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Blood glucose response after oral intake of lactulose in healthy volunteers: A randomized, controlled, cross-over study by Steudle, Jasmin, Schön, Christiane, Wargenau, Manfred, Pauly, Lioba, Schwejda-Güttes, Susann, Gaigg, Barbara, Kuchinka-Koch, Angelika, Stover, John F

“…To investigate possible changes of blood glucose levels after oral intake of lactulose in healthy subjects. The study was performed as prospective, randomized,…”
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Evaluation of the bioequivalence of tablet and capsule formulations of granisetron in patients undergoing cytotoxic chemotherapy for malignant disease by Cupissol, D, Bressolle, F, Adenis, L, Carmichael, J, Bessell, E, Allen, A, Wargenau, M, Romain, D

“…Granisetron is a novel, highly specific 5-hydroxytryptamine receptor antagonist given prophylactically to patients undergoing chemotherapy. An open,…”
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The pharmacokinetics and tolerability of an intravenous infusion of the new hydroxyethyl starch 130/0.4 (6%, 500 mL) in mild-to-severe renal impairment by JUNGHEINRICH, Cornelius, SCHARPF, Roland, WARGENAU, Manfred, BEPPERLING, Frank, BARON, Jean-Francois

“…Hydroxyethyl starches (HES) are almost exclusively excreted glomerularly, in part after hydrolysis by amylase. HES 130/0.4 (Voluven; Fresenius Kabi Deutschland…”
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Formulation-dependent food effects demonstrated for nifedipine modified-release preparations marketed in the European Union by Schug, Barbara S, Brendel, Erich, Wolf, Dörte, Wonnemann, Meinolf, Wargenau, Manfred, Blume, Henning H

“…The objective of this study was a comparative investigation of the influence of concomitant food intake on the bioavailability of two nifedipine-containing…”
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