Search Results - "Warejcka, Debra J."

Urokinase receptor cleavage: a crucial step in fibroblast-to-myofibroblast differentiation by Bernstein, Audrey M, Twining, Sally S, Warejcka, Debra J, Tall, Edward, Masur, Sandra K

“…Fibroblasts migrate into and repopulate connective tissue wounds. At the wound edge, fibroblasts differentiate into myofibroblasts, and they promote wound…”
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Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts by Horswill, Mark A., Narayan, Malathi, Warejcka, Debra J., Cirillo, Lisa A., Twining, Sally S.

“…Maspin, a 42kDa non-classical serpin (serine protease inhibitor) that controls cell migration and invasion, is mainly expressed by epithelial-derived cells but…”
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Thrombin alters the synthesis and processing of CYR61/CCN1 in human corneal stromal fibroblasts and myofibroblasts through multiple distinct mechanisms by Andreae, Emily A, Warejcka, Debra J, Twining, Sally S

“…Previous research in our laboratory indicated that prothrombin and other coagulation enzymes required to activate prothrombin to thrombin are synthesized by…”
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Specific conformational changes of plasminogen induced by chloride ions, 6-aminohexanoic acid and benzamidine, but not the overall openness of plasminogen regulate, production of biologically active angiostatins by Warejcka, Debra J, Twining, Sally S

“…The overall conformation of plasminogen depends upon the presence of anions and molecules such as AHA (6-aminohexanoic acid) and BZ (benzamidine). The purpose…”
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Maspin increases extracellular plasminogen activator activity associated with corneal fibroblasts and myofibroblasts by Warejcka, Debra J., Narayan, Malathi, Twining, Sally S.

“…Maspin, an inhibitor of cell migration and a stimulator of adhesion of cells to the ECM, is synthesized and released by corneal keratocytes into the…”
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Expression of insulin-like growth factor 2 receptor in corneal keratocytes during differentiation and in response to wound healing by Bohnsack, Richard N, Warejcka, Debra J, Wang, Lingyan, Gillespie, Stephanie R, Bernstein, Audrey M, Twining, Sally S, Dahms, Nancy M

“…Insulin-like growth factor 2 receptor (IGF2R) associates with ligands that influence wound healing outcomes. However, the expression pattern of IGF2R and its…”
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Sufficiency of the reactive site loop of maspin for induction of cell-matrix adhesion and inhibition of cell invasion. Conversion of ovalbumin to a maspin-like molecule by Ngamkitidechakul, Chatri, Warejcka, Debra J, Burke, Janice M, O'Brien, William J, Twining, Sally S

“…Maspin, an ov-serpin, inhibits tumor invasion and induces cell adhesion to extracellular matrix molecules. Here, we use maspin/ovalbumin chimeric proteins and…”
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Corneal Activation of Prothrombin to Form Thrombin, Independent of Vascular Injury by Ayala, Aidee, Warejcka, Debra J, Olague-Marchan, Monica, Twining, Sally S

“…Two major functions of thrombin observed in the cornea are activation of thrombin-sensitive, proteinase-activated receptors and cleavage of fibrinogen to…”
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Differential conversion of plasminogen to angiostatin by human corneal cell populations by Warejcka, Debra J, Vaughan, Kimberly A, Bernstein, Audrey M, Twining, Sally S

“…Maintenance of avascularity of the normal cornea and control of neovascularization during wound healing depend on a balance of angiogenic and antiangiogenic…”
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Formation of Abdominal Adhesions Is Inhibited by Antibodies to Transforming Growth Factor-β1 by Lucas, Paul A., Warejcka, Debra J., Young, Henry E., Lee, Bok Y.

“…Transforming growth factor-β (TGF-β) is an important factor in regulating the inflammatory response and the production of extracellular matrix by fibroblasts…”
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Sufficiency of the Reactive Site Loop of Maspin for Induction of Cell-Matrix Adhesion and Inhibition of Cell Invasion by Ngamkitidechakul, Chatri, Warejcka, Debra J., Burke, Janice M., O'Brien, William J., Twining, Sally S.

“…Maspin, an ov-serpin, inhibits tumor invasion and induces cell adhesion to extracellular matrix molecules. Here, we use maspin/ovalbumin chimeric proteins and…”
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Stimulation of β-adrenergic receptors inhibits the release of tumor necrosis factor-α from the isolated rat heart by NEWMAN, Walter H, CASTRESANA, Manuel R, WEBB, Jerry G, ZHONGBIAO WANG, WAREJCKA, Debra J

“…Beta-adrenergic receptor agonists such as isoproterenol inhibit production of tumor necrosis factor (TNF)-alpha in a number of cell types. Because the heart is…”
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STIMULATION OF β-ADRENERGIC RECEPTORS INHIBITS TUMOR NECROSIS FACTOR ALPHA RELEASE FROM THE ISOLATED RAT HEART by Newman, Walter H, Castresana, Manuel R, Wang, Zhongbiao, Dalton, Martin L, Warejcka, Debra J

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Maspin, the Molecular Bridge between the Plasminogen Activator System and β1 Integrin That Facilitates Cell Adhesion by Endsley, Michael P., Hu, Yanqiu, Deng, Yong, He, Xiaolin, Warejcka, Debra J., Twining, Sally S., Gonias, Steven L., Zhang, Ming

“…Maspin is a non-inhibitory serine protease inhibitor (serpin) that influences many cellular functions including adhesion, migration, and invasion. The…”
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Maspin, the molecular bridge between the plasminogen activator system and beta1 integrin that facilitates cell adhesion by Endsley, Michael P, Hu, Yanqiu, Deng, Yong, He, Xiaolin, Warejcka, Debra J, Twining, Sally S, Gonias, Steven L, Zhang, Ming

“…Maspin is a non-inhibitory serine protease inhibitor (serpin) that influences many cellular functions including adhesion, migration, and invasion. The…”
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Inhibition of epidural scar formation after lumbar laminectomy in the rat by Hinton, Jr, J L, Warejcka, D J, Mei, Y, McLendon, R E, Laurencin, C, Lucas, P A, Robinson, Jr, J S

“…An animal model of laminectomy in rats was used to study scar tissue formation around the spinal cord. Dexamethasone, in controlled-release form, was tested in…”
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ASPIRIN INHIBITS BACTERIAL LIPOPOLYSACCHARIDE (LPS) STIMULATED RELEASE OF TUMOR NECROSIS FACTOR ALPHA (TNF-alpha) FROM THE ISOLATED RAT HEART by Newman, Walter H., Castresana, Manuel R., Erceg, Stefan K., Warejcka, Debra J.

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NUCLEAR TRANSCRIPTION FACTOR, NF-[Greek small letter kappa]B, AND THE REGULATION OF RELEASE OF TUMOR NECROSIS FACTOR-[Greek small letter alpha] FROM RAT VASCULAR SMOOTH MUSCLE CELLS by Castresana, Manuel R., Leeper-Woodford, Sandra K., Warejcka, Debra J, Detmer, Kristina, Newman, Walter H.

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A Population of Cells Isolated from Rat Heart Capable of Differentiating into Several Mesodermal Phenotypes by Warejcka, Debra J., Harvey, Richard, Taylor, B.Jackson, Young, Henry E., Lucas, Paul A.

“…A population of stem cells has been isolated from embryonic avian and neonatal rat skeletal muscle. These cells differentiate into several mesodermal…”
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Effect of Rat Mesenchymal Stem Cells on Development of Abdominal Adhesions after Surgery by Lucas, Paul A., Warejcka, Debra J., Zhang, Li-Ming, Newman, Walter H., Young, Henry E.

“…One of the common and most serious side effects of abdominal surgery is the formation of adhesions within the peritoneal cavity during healing. Efforts to…”
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