Search Results - "Wareham, D. W."

In Vivo Efficacy of Glycopeptide-Colistin Combination Therapies in a Galleria mellonella Model of Acinetobacter baumannii Infection by HORNSEY, M, WAREHAM, D. W

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Development and evaluation of a multiplex PCR for eight plasmid-mediated quinolone-resistance determinants by CIESIELCZUK, H, HORNSEY, M, CHOI, V, WOODFORD, N, WAREHAM, D. W

“…The objective of this study was to develop and validate an expanded multiplex PCR assay for the simultaneous detection of eight plasmid-mediated…”
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Potent Synergy and Sustained Bactericidal Activity of a Vancomycin-Colistin Combination versus Multidrug-Resistant Strains of Acinetobacter baumannii by Gordon, N C, Png, K, Wareham, D W

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A review of clinical and microbiological outcomes following treatment of infections involving multidrug-resistant Acinetobacter baumannii with tigecycline by Gordon, N. C., Wareham, D. W.

“…Objectives Multidrug-resistant Acinetobacter baumannii (MRAB) is an increasing problem in UK hospitals, with many strains now resistant to all available…”
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In vitro activity of teicoplanin combined with colistin versus multidrug-resistant strains of Acinetobacter baumannii by WAREHAM, D. W, GORDON, N. C, HORNSEY, M

“…Antimicrobial treatment of multidrug-resistant Acinetobacter baumannii (MDRAB) remains an important therapeutic challenge. With isolates resistant to all…”
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Novel variants of the Smqnr family of quinolone resistance genes in clinical isolates of Stenotrophomonas maltophilia by Gordon, N. C., Wareham, D. W.

“…Background Recent analysis of Stenotrophomonas maltophilia has identified a novel family of resistance genes (Smqnr) encoding pentapeptide repeat proteins,…”
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Activity of colistin in combination with tigecycline or rifampicin against multidrug-resistant Stenotrophomonas maltophilia by Betts, J. W., Phee, L. M., Woodford, N., Wareham, D. W.

“…The antimicrobial treatment of Stenotrophomonas maltophilia infections is complicated by intrinsic multidrug resistance and a lack of reliable susceptibility…”
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In vitro activity of daptomycin in combination with low-dose colistin against a diverse collection of Gram-negative bacterial pathogens by Phee, L., Hornsey, M., Wareham, D. W.

“…The activity of colistin in combination with daptomycin was assessed using 30 Gram-negative type strains and multidrug-resistant isolates with defined…”
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Evaluation of CHROMagar Acinetobacter for Detection of Enteric Carriage of Multidrug-Resistant Acinetobacter baumannii in Samples from Critically Ill Patients by Gordon, N.C, Wareham, D.W

“…CHROMagar Acinetobacter was used to screen stool and perineal swabs for enteric carriage of multidrug-resistant Acinetobacter baumannii in samples from…”
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Bloodstream infection due to Acinetobacter spp: epidemiology, risk factors and impact of multi-drug resistance by Wareham, D. W., Bean, D. C., Khanna, P., Hennessy, E. M., Krahe, D., Ely, A., Millar, M.

“…Acinetobacter spp. are increasingly reported as important causes of human infection. Many isolates exhibit multi-drug resistance, raising concerns over our…”
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Modifications to CHROMagar Acinetobacter for improved selective growth of multi-drug resistant Acinetobacter baumannii by Wareham, D W, Gordon, N C

“…Performance of CHROMagar Acinetobacter was assessed for the selective isolation and identification of Acinetobacter baumannii. The medium was effective in…”
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Failure of the MicroScan WalkAway System To Detect Heteroresistance to Carbapenems in a Patient with Enterobacter aerogenes Bacteremia by GORDON, N. C, WAREHAM, D. W

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Paradoxical effect of 1-(1-naphthylmethyl)-piperazine on resistance to tetracyclines in multidrug-resistant Acinetobacter baumannii by Bean, D. C., Wareham, D. W.

“…Objectives The efflux inhibitor 1-(1-naphthylmethyl)-piperazine (NMP) has been demonstrated to reverse multidrug resistance in Acinetobacter baumannii. We…”
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Allele-specific polymerase chain reaction (PCR) for rapid detection of the aac(6 ′ )-Ib-cr quinolone resistance gene by Wareham, D.W, Umoren, I, Khanna, P, Gordon, N.C

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Carbapenemase-producing Enterobacteriaceae and non-Enterobacteriaceae from animals and the environment: an emerging public health risk of our own making? by Woodford, Neil, Wareham, David W, Guerra, Beatriz, Teale, Christopher

“…Acquired carbapenemases pose one of the most pressing public health threats relating to antibiotic resistance. In most countries, the number of…”
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Genetic analysis of mechanisms of multidrug resistance in a clinical isolate of Bacteroides fragilis by Pumbwe, L., Wareham, D.W., Aduse-Opoku, J., Brazier, J.S., Wexler, H.M.

“…This study investigated the mechanisms of multidrug resistance (MDR) in an isolate of Bacteroides fragilis (WI1) from a patient with anaerobic sepsis. The MDR…”
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Polymicrobial necrotizing fasciitis involving enterobacteria producing CTX-M-15 extended-spectrum β-lactamases by SOLEIMANIAN, S, GORDON, N. C, WAREHAM, D. W

“…Necrotizing fasciitis due to multiple Gram-negative organisms in a Nigerian patient is described. Morganella morganii and Citrobacter freundii carrying the…”
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The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections by Tängdén, T., Ramos Martín, V., Felton, T. W., Nielsen, E. I., Marchand, S., Brüggemann, R. J., Bulitta, J. B., Bassetti, M., Theuretzbacher, U., Tsuji, B. T., Wareham, D. W., Friberg, L. E., De Waele, J. J., Tam, V. H., Roberts, Jason A.

“…Critically ill patients with severe infections are at high risk of suboptimal antimicrobial dosing. The pharmacokinetics (PK) and pharmacodynamics (PD) of…”
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Anaerobic Sepsis Due to Multidrug-Resistant Bacteroides fragilis: Microbiological Cure and Clinical Response with Linezolid Therapy by Wareham, D. W., Wilks, M., Ahmed, D., Brazier, J. S., Millar, M.

“…We describe the first reported case of anaerobic sepsis due to Bacteroides fragilis with simultaneous resistance to metronidazole, β-lactams,…”
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Treatment of prosthetic valve infective endocarditis due to multi-resistant Gram-positive bacteria with linezolid by Wareham, D.W., Abbas, H., Karcher, A.M., Das, S.S.

“…Clinical experience with linezolid in the treatment of infective endocarditis either alone or in combination with other agents is limited. We describe our…”
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