Search Results - "Ware, Carl"

Clinical targeting of the TNF and TNFR superfamilies by Croft, Michael, Benedict, Chris A., Ware, Carl F.

“…Key Points Inhibitors of tumour necrosis factor (TNF) are among the most successful protein-based drugs for reducing inflammation associated with several…”
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The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses by Ward-Kavanagh, Lindsay K., Lin, Wai Wai, Šedý, John R., Ware, Carl F.

“…Cytokines related to tumor necrosis factor (TNF) provide a communication network essential for coordinating multiple cell types into an effective host defense…”
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Realigning the LIGHT signaling network to control dysregulated inflammation by Ware, Carl F, Croft, Michael, Neil, Garry A

“…Advances in understanding the physiologic functions of the tumor necrosis factor superfamily (TNFSF) of ligands, receptors, and signaling networks are…”
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Targeting the TNF and TNFR superfamilies in autoimmune disease and cancer by Croft, Michael, Salek-Ardakani, Shahram, Ware, Carl F

“…The first anti-tumour necrosis factor (TNF) monoclonal antibody, infliximab (Remicade), celebrated its 25th anniversary of FDA approval in 2023. Inhibitors of…”
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Network communications: lymphotoxins, LIGHT, and TNF by Ware, Carl F

“…Lymphotoxins (LT) provide essential communication links between lymphocytes and the surrounding stromal and parenchymal cells and together with the two related…”
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Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation by Lechtenberg, Bernhard C., Rajput, Akhil, Sanishvili, Ruslan, Dobaczewska, Małgorzata K., Ware, Carl F., Mace, Peter D., Riedl, Stefan J.

“…Ubiquitination is a central process affecting all facets of cellular signalling and function 1 . A critical step in ubiquitination is the transfer of ubiquitin…”
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Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways by Ware, Carl F

“…Cytokines mediate key communication pathways essential for regulation of immune responses. Full activation of antigen-responding lymphocytes requires…”
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The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation by Nakhaei, Peyman, Mesplede, Thibault, Solis, Mayra, Sun, Qiang, Zhao, Tiejun, Yang, Long, Chuang, Tsung-Hsien, Ware, Carl F, Lin, Rongtuan, Hiscott, John

“…The primary role of the innate immune response is to limit the spread of infectious pathogens, with activation of Toll-like receptor (TLR) and RIG-like…”
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Tumor necrosis factor superfamily in innate immunity and inflammation by Šedý, John, Bekiaris, Vasileios, Ware, Carl F

“…The tumor necrosis factor superfamily (TNFSF) and its corresponding receptor superfamily (TNFRSF) form communication pathways required for developmental,…”
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Lymphotoxin-β Receptor Signaling through NF-κB2-RelB Pathway Reprograms Adipocyte Precursors as Lymph Node Stromal Cells by Bénézech, Cécile, Mader, Emma, Desanti, Guillaume, Khan, Mahmood, Nakamura, Kyoko, White, Andrea, Ware, Carl F., Anderson, Graham, Caamaño, Jorge H.

“…Lymph node development during embryogenesis involves lymphotoxin-β receptor engagement and subsequent differentiation of a poorly defined population of…”
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The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation by Steinberg, Marcos W., Cheung, Timothy C., Ware, Carl F.

“…The tumor necrosis factor (TNF) receptor superfamily member herpesvirus entry mediator (HVEM) (TNFRSF14) regulates T‐cell immune responses by activating both…”
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The Inhibitory Receptor BTLA Controls γδ T Cell Homeostasis and Inflammatory Responses by Bekiaris, Vasileios, Šedý, John R., Macauley, Matthew G., Rhode-Kurnow, Antje, Ware, Carl F.

“…γδ T cells rapidly secrete inflammatory cytokines at barrier sites that aid in protection from pathogens, but mechanisms limiting inflammatory damage remain…”
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The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis by Mintz, Michelle A., Felce, James H., Chou, Marissa Y., Mayya, Viveka, Xu, Ying, Shui, Jr-Wen, An, Jinping, Li, Zhongmei, Marson, Alexander, Okada, Takaharu, Ware, Carl F., Kronenberg, Mitchell, Dustin, Michael L., Cyster, Jason G.

“…The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell…”
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Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt + Innate Lymphocytes by Vonarbourg, Cedric, Mortha, Arthur, Bui, Viet L., Hernandez, Pedro P., Kiss, Elina A., Hoyler, Thomas, Flach, Melanie, Bengsch, Bertram, Thimme, Robert, Hölscher, Christoph, Hönig, Manfred, Pannicke, Ulrich, Schwarz, Klaus, Ware, Carl F., Finke, Daniela, Diefenbach, Andreas

“…Whether the recently identified innate lymphocyte population coexpressing natural killer cell receptors (NKRs) and the nuclear receptor RORγt is part of the NK…”
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Randomized, double-blind, controlled trial of human anti-LIGHT monoclonal antibody in COVID-19 acute respiratory distress syndrome by Perlin, David S, Neil, Garry A, Anderson, Colleen, Zafir-Lavie, Inbal, Raines, Shane, Ware, Carl F, Wilkins, H Jeffrey

“…BACKGROUNDSevere coronavirus disease 2019 (COVID-19) is associated with a dysregulated immune response, which can result in cytokine-release syndrome and acute…”
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The TNF receptor super family in immune regulation by Ware, Carl F.

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CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA by Flynn, Rachel, Hutchinson, Tarun, Murphy, Kenneth M, Ware, Carl F, Croft, Michael, Salek-Ardakani, Shahram

“…Defining the molecular interactions required to program activated CD8 T cells to survive and become memory cells may allow us to understand how to augment…”
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BTLA interaction with HVEM expressed on CD8(+) T cells promotes survival and memory generation in response to a bacterial infection by Steinberg, Marcos W, Huang, Yujun, Wang-Zhu, Yiran, Ware, Carl F, Cheroutre, Hilde, Kronenberg, Mitchell

“…The B and T lymphocyte attenuator (BTLA) is an Ig super family member that binds to the herpes virus entry mediator (HVEM), a TNF receptor super family…”
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Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues by Guendel, Fabian, Kofoed-Branzk, Michael, Gronke, Konrad, Tizian, Caroline, Witkowski, Mario, Cheng, Hung-Wei, Heinz, Gitta Anne, Heinrich, Frederik, Durek, Pawel, Norris, Paula S., Ware, Carl F., Ruedl, Christiane, Herold, Susanne, Pfeffer, Klaus, Hehlgans, Thomas, Waisman, Ari, Becher, Burkhard, Giannou, Anastasios D., Brachs, Sebastian, Ebert, Karolina, Tanriver, Yakup, Ludewig, Burkhard, Mashreghi, Mir-Farzin, Kruglov, Andrey A., Diefenbach, Andreas

“…Solitary intestinal lymphoid tissues such as cryptopatches (CPs) and isolated lymphoid follicles (ILFs) constitute steady-state activation hubs containing…”
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Regnase-1 is essential for B cell homeostasis to prevent immunopathology by Bhat, Numana, Virgen-Slane, Richard, Ramezani-Rad, Parham, Leung, Charlotte R, Chen, Cindi, Balsells, Daniel, Shukla, Ashima, Kao, Elaine, Apgar, John R, Fu, Mingui, Ware, Carl F, Rickert, Robert C

“…Regnase-1 is an emerging regulator of immune responses with essential roles in the posttranscriptional control of immune cell activation. Regnase-1 is…”
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