Search Results - "Wardwell, Leslie"

Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission by Rooks, Michelle G, Veiga, Patrick, Wardwell-Scott, Leslie H, Tickle, Timothy, Segata, Nicola, Michaud, Monia, Gallini, Carey Ann, Beal, Chloé, van Hylckama-Vlieg, Johan ET, Ballal, Sonia A, Morgan, Xochitl C, Glickman, Jonathan N, Gevers, Dirk, Huttenhower, Curtis, Garrett, Wendy S

“…Dysregulated immune responses to gut microbes are central to inflammatory bowel disease (IBD), and gut microbial activity can fuel chronic inflammation…”
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SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas by Meyerson, Matthew, Bass, Adam J, Watanabe, Hideo, Mermel, Craig H, Yu, Soyoung, Perner, Sven, Verhaak, Roel G, Kim, So Young, Wardwell, Leslie, Tamayo, Pablo, Gat-Viks, Irit, Ramos, Alex H, Woo, Michele S, Weir, Barbara A, Getz, Gad, Beroukhim, Rameen, O'Kelly, Michael, Dutt, Amit, Rozenblatt-Rosen, Orit, Dziunycz, Piotr, Komisarof, Justin, Chirieac, Lucian R, LaFargue, Christopher J, Scheble, Veit, Wilbertz, Theresia, Ma, Changqing, Rao, Shilpa, Nakagawa, Hiroshi, Stairs, Douglas B, Lin, Lin, Giordano, Thomas J, Wagner, Patrick, Minna, John D, Gazdar, Adi F, Zhu, Chang Qi, Brose, Marcia S, Cecconello, Ivan, Jr, Ulysses Ribeiro, Marie, Suely K, Dahl, Olav, Shivdasani, Ramesh A, Tsao, Ming-Sound, Rubin, Mark A, Wong, Kwok K, Regev, Aviv, Hahn, William C, Beer, David G, Rustgi, Anil K

“…Matthew Meyerson and colleagues report that SOX2 , which encodes a transcription factor necessary for normal esophageal development, is an amplified lineage…”
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Current Concepts of the Intestinal Microbiota and the Pathogenesis of Infection by Wardwell, Leslie H., Huttenhower, Curtis, Garrett, Wendy S.

“…The human gastrointestinal tract is populated by a vast and diverse community of microbes. This gut microbiota participates in host metabolism, protects from…”
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QseC inhibition as an antivirulence approach for colitis-associated bacteria by Rooks, Michelle G., Veiga, Patrick, Reeves, Analise Z., Lavoie, Sydney, Yasuda, Koji, Asano, Yasunari, Yoshihara, Kazufumi, Michaud, Monia, Wardwell-Scott, Leslie, Gallini, Carey Ann, Glickman, Jonathan N., Sudo, Nobuyuki, Huttenhower, Curtis, Lesser, Cammie F., Garrett, Wendy S.

“…Hosts and their microbes have established a sophisticated communication system over many millennia. Within mammalian hosts, this dynamic cross-talk is…”
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CK1epsilon is required for breast cancers dependent on beta-catenin activity by Kim, So Young, Dunn, Ian F, Firestein, Ron, Gupta, Piyush, Wardwell, Leslie, Repich, Kara, Schinzel, Anna C, Wittner, Ben, Silver, Serena J, Root, David E, Boehm, Jesse S, Ramaswamy, Sridhar, Lander, Eric S, Hahn, William C

“…Aberrant beta-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate beta-catenin…”
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Clinical translation of anti-inflammatory effects of Prevotella histicola in Th1, Th2, and Th17 inflammation by Itano, Andrea, Maslin, Douglas, Ramani, Kritika, Mehraei, Golbarg, Carpenter, Nancy, Cormack, Taylor, Saghari, Mahdi, Moerland, Matthijs, Troy, Erin, Caffry, Will, Wardwell-Scott, Leslie, Abel, Stuart, McHale, Duncan, Bodmer, Mark

“…EDP1815 is a non-colonizing pharmaceutical preparation of a single stain of isolated from the duodenum of a human donor. We report here preclinical and…”
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Co-selection of Mercury and Antibiotic Resistance in Sphagnum Core Samples Dating Back 2000 Years by Wardwell, Leslie H., Jude, Brooke A., Moody, Jennifer P., Olcerst, Aaron I., Gyure, Ruth A., Nelson, Robert E., Fekete, Frank A.

“…Metal exposure might induce multiple drug resistance (MDR) in bacteria in environments devoid of antibiotics via the process of co-selection, but the extent is…”
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Co-Selection of Mercury and Antibiotic Resistance in Sphagnum Core Samples Dating Back 2000 Years by Wardwell, Leslie H., Jude, Brooke A., Moody, Jennifer P., Olcerst, Aaron I., Gyure, Ruth A., Nelson, Robert E., Fekete, Frank A.

“…Metal exposure might induce multiple drug resistance (MDR) in bacteria in environments devoid of antibiotics via the process of co-selection, but the extent is…”
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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation by Emery, Caroline M, Hieronymus, Haley, Zhao, Jean J, Boehm, Jesse S, Golub, Todd, Yang, Xiaoping, Root, David E, Roberts, Thomas M, Hahn, William C, Hill, David E, Wilson, Christopher J, Weber, Barbara L, Garraway, Levi A, Johnson, Laura A, Kim, Sungjoon, Harris, Jennifer L, Kim, So Young, Vidal, Marc, Finan, Peter M, Myer, Vic E, Sellers, William R, Barretina, Jordi, Alkan, Ozan, Thomas, Sapana R, Wardwell, Leslie, Cogdill, Alexandria P, Dummer, Reinhard, Schlegel, Robert, Stransky, Nicolas, Flaherty, Keith T, Wargo, Jennifer A, Murray, Ryan R, Johannessen, Cory M, Salehi-Ashtiani, Kourosh, Caponigro, Giordano

“…Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have…”
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CK1ε Is Required for Breast Cancers Dependent on β-Catenin Activity by Kim, So Young, Dunn, Ian F., Firestein, Ron, Gupta, Piyush, Wardwell, Leslie, Repich, Kara, Schinzel, Anna C., Wittner, Ben, Silver, Serena J., Root, David E., Boehm, Jesse S., Ramaswamy, Sridhar, Lander, Eric S., Hahn, William C.

“…Background Aberrant β-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate…”
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Abstract 5769: A novel, high-throughput approach to discovering drug-resistance genes identifies CRAF, CrkL, and TPL2/COT as drivers of resistance to BRAFV600E inhibition by Johannessen, Cory M., Wardwell, Leslie, Kim, So Young, Boehm, Jesse, Thomas, Sapana, Johnson, Laura A., Hieronymus, Haley, Salehi-Ashtiani, Kourosh, Hill, David E., Zhao, Jean J., Vidal, Marc, Golub, Todd R., Hahn, William C., Garraway, Levi A.

“…Activating mutations in the BRAF kinase are found in 50-70% of melanomas and have nominated BRAF, along with downstream components of the MAP kinase pathway,…”
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CK1[epsilon] Is Required for Breast Cancers Dependent on [beta]-Catenin Activity by Kim, So Young, Dunn, Ian F, Firestein, Ron, Gupta, Piyush, Wardwell, Leslie, Repich, Kara, Schinzel, Anna C, Wittner, Ben, Silver, Serena J, Root, David E, Boehm, Jesse S, Ramaswamy, Sridhar, Lander, Eric S, Hahn, William C

“…Background Aberrant [beta]-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate…”
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COT/MAP3K8 drives resistance to RAF inhibition through MAP kinase pathway reactivation by Johannessen, Cory M., Boehm, Jesse S., Kim, So Young, Thomas, Sapana R., Wardwell, Leslie, Johnson, Laura A., Emery, Caroline M., Stransky, Nicolas, Cogdill, Alexandria P., Barretina, Jordi, Caponigro, Giordano, Hieronymus, Haley, Murray, Ryan R., Salehi-Ashtiani, Kourosh, Hill, David E., Vidal, Marc, Zhao, Jean J., Yang, Xiaoping, Alkan, Ozan, Kim, Sungjoon, Harris, Jennifer L., Wilson, Christopher J., Myer, Vic E., Finan, Peter M., Root, David E., Roberts, Thomas M., Golub, Todd, Flaherty, Keith T., Dummer, Reinhard, Weber, Barbara, Sellers, William R., Schlegel, Robert, Wargo, Jennifer A., Hahn, William C., Garraway, Levi A.

“…Oncogenic mutations in the serine/threonine kinase B-RAF are found in 50–70% of malignant melanomas 1 . Pre-clinical studies have demonstrated that the B-RAF…”
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Functional and Genomic Analyses of Klebsiella pneumoniae Population Dynamics in the Gastrointestinal Tract by Wardwell-Scott, Leslie Hansen

“…The gastrointestinal tract is home to trillions of bacteria that interact with each other and with the host’s mucosal immune system. Obligate and facultative…”
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