Search Results - "Wardlaw, JM"

Systematic review of evidence on thrombolytic therapy for acute ischaemic stroke by Wardlaw, J M, Warlow, C P, Counsell, C

“…Recent trials of thrombolytic therapy in acute ischaemic stroke have given apparently conflicting results. Only one trial, the National Institute of…”
Get more information

Thrombolysis for acute ischaemic stroke by Wardlaw, Joanna M, Murray, Veronica, Berge, Eivind, del Zoppo, Gregory J

“…Most strokes are due to blockage of an artery in the brain by a blood clot. Prompt treatment with thrombolytic drugs can restore blood flow before major brain…”
Get more information

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis by Wardlaw, Joanna M, Prof, Murray, Veronica, Prof, Berge, Eivind, Prof, del Zoppo, Gregory, Prof, Sandercock, Peter, Prof, Lindley, Richard L, Prof, Cohen, Geoff, PhD

“…Summary Background Recombinant tissue plasminogen activator (rt-PA, alteplase) improved functional outcome in patients treated soon after acute ischaemic…”
Get full text

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial by Bath, PMW, Woodhouse, L, Scutt, P, Krishnan, K, Wardlaw, JM, Bereczki, D, Sprigg, N, Berge, E, Beridze, M, Caso, V, Chen, C, Christensen, H, Collins, R, El Etribi, A, Laska, AC, Lees, KR, Ozturk, S, Phillips, S, Pocock, S, de Silva, HA, Szatmari, S, Utton, S

“…Summary Background High blood pressure is associated with poor outcome after stroke. Whether blood pressure should be lowered early after stroke, and whether…”
Get full text

Thrombolysis for acute ischaemic stroke by Wardlaw, Joanna M, Murray, Veronica, Berge, Eivind, Del Zoppo, Gregory J

“…The majority of strokes are due to blockage of an artery in the brain by a blood clot. Prompt treatment with thrombolytic drugs can restore blood flow before…”
Get more information

The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial by Sandercock, Peter, Wardlaw, Joanna M, Lindley, Richard I, Dennis, Martin, Cohen, Geoff, Murray, Gordon, Innes, Karen, Venables, Graham, Czlonkowska, Anna, Kobayashi, Adam, Ricci, Stefano, Murray, Veronica, Berge, Eivind, Slot, Karsten Bruins, Hankey, Graeme J, Correia, Manuel, Peeters, Andre, Matz, Karl, Lyrer, Phillippe, Gubitz, Gord, Phillips, Stephen J, Arauz, Antonio

“…Summary Background Thrombolysis is of net benefit in patients with acute ischaemic stroke, who are younger than 80 years of age and are treated within 4·5 h of…”
Get full text

Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third International Stroke Trial (IST-3): secondary analysis of a randomised controlled trial by Wardlaw, Joanna M, Sandercock, Peter, Cohen, Geoff, Farrall, Andrew, Lindley, Richard, von Kummer Dresden, Rudiger, von Heijne, Anders, Bradey, Nick, Peeters, Andre, Cala, Lesley, Adami, Alessandro, Morris, Zoe, Potter, Gillian, Murray, Gordon, Whiteley, Will, Perry, David, Sakka, Eleni, Lundström, Erik

“…Summary Background Brain scans are essential to exclude haemorrhage in patients with suspected acute ischaemic stroke before treatment with alteplase. However,…”
Get full text

Early signs of brain infarction at CT: observer reliability and outcome after thrombolytic treatment--systematic review by Wardlaw, Joanna M, Mielke, Orell

“…To review systematically all reported early computed tomographic (CT) signs in acute ischemic stroke to determine interobserver agreement and the relationship…”
Get more information

What causes lacunar stroke? by Wardlaw, J M

“…[...]lacunar stroke symptoms (more than other stroke subtypes) not uncommonly progress after onset. 44 Perhaps the interstitial fluid composition eventually…”
Get full text

Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis by Wardlaw, JM, Chappell, FM, Best, JJK, Wartolowska, K, Berry, E

“…Accurate carotid imaging is important for effective secondary stroke prevention. Non-invasive imaging, now widely available, is replacing intra-arterial…”
Get full text

Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial by Sandercock, Peter, Joanna, Wardlaw, Dennis, Martin, Cohen, Geoff, Murray, Gordon, Innes, Karen, Whiteley, Will, Lindley, Richard, Venables, Graham, Czlonkowska, Anna, Kobayashi, Adam, Ricci, Stefano, Myrray, Verronica, Berge, Eivind, Slot, Karsten, Hankey, Graeme J, Correia, Manuel, Peeters, Andre, Matz, Mats, Lyrer, Phillippe, Gubitz, Gord, Phillips, Stephen J, Arauz, Antonio, Lundström, E

“…Summary Background Few data are available from randomised trials about the effect of thrombolysis with alteplase on long-term functional outcome in patients…”
Get full text

Distinguishing between stroke and mimic at the bedside the brain attack study by HAND, Peter J, KWAN, Joseph, LINDLEY, Richard I, DENNIS, Martin S, WARDLAW, Joanna M

“…The bedside clinical assessment of the patient with suspected stroke has not been well studied. Improving clinical skills may accelerate patient progress…”
Get full text

Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review and meta-analysis by Ball, Emily L, Sutherland, Rachel, Squires, Charlotte, Mead, Gillian E, Religa, Dorota, Lundström, Erik, Cheyne, Joshua, Wardlaw, Joanna M, Quinn, Terence J, Shenkin, Susan D

“…Background Identifying whether acute stroke patients are at risk of cognitive decline could improve prognostic discussions and management. Structural computed…”
Get full text

Association of Vascular Risk Factors and Cerebrovascular Pathology With Alzheimer Disease Pathologic Changes in Individuals Without Dementia by Lorenzini, Luigi, Maranzano, Alessio, Ingala, Silvia, Collij, Lyduine E, Tranfa, Mario, Blennow, Kaj, Di Perri, Carol, Foley, Christopher, Fox, Nick C, Frisoni, Giovanni B, Haller, Sven, Martinez-Lage, Pablo, Mollison, Daisy, O'Brien, John, Payoux, Pierre, Ritchie, Craig, Scheltens, Philip, Schwarz, Adam J, Sudre, Carole H, Tijms, Betty M, Verde, Federico, Ticozzi, Nicola, Silani, Vincenzo, Visser, Pieter Jelle, Waldman, Adam, Wolz, Robin, Chételat, Gael, Ewers, Michael, Wink, Alle Meije, Mutsaerts, Henk, Gispert, Juan Domingo, Wardlaw, Joanna M, Barkhof, Frederik

“…Vascular risk factors (VRFs) and cerebral small vessel disease (cSVD) are common in patients with Alzheimer disease (AD). It remains unclear whether this…”
Get full text

Predictors of post-stroke cognitive impairment using acute structural MRI neuroimaging: A systematic review and meta-analysis by Ball, Emily L, Shah, Mahnoor, Ross, Eilidh, Sutherland, Rachel, Squires, Charlotte, Mead, Gillian E, Wardlaw, Joanna M, Quinn, Terence J, Religa, Dorota, Lundström, Erik, Cheyne, Joshua, Shenkin, Susan D

“…Background: Stroke survivors are at an increased risk of developing post-stroke cognitive impairment and post-stroke dementia; those at risk could be…”
Get full text

Multinational Survey of Current Practice from Imaging to Treatment of Atherosclerotic Carotid Stenosis by Saba, Luca, Mossa-Basha, Mahmoud, Abbott, Anne, Lanzino, Giuseppe, Wardlaw, Joanna M, Hatsukami, Thomas S, Micheletti, Giulio, Balestrieri, Antonella, Hedin, Ulf, Moody, Alan R, Wintermark, Max, DeMarco, J Kevin

“…In the last 20-30 years, there have been many advances in imaging and therapeutic strategies for symptomatic and asymptomatic individuals with carotid artery…”
Get more information

Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort by Hamilton, OKL, Cox, SR, Ballerini, L, Bastin, ME, Corley, J, Gow, AJ, Muñoz Maniega, S, Redmond, P, Valdés Hernández, M del C, Wardlaw, JM, Deary, IJ

“…•Greater SVD burden associates with poorer abilities in all major cognitive domains.•SVD associates with memory and visuospatial due to covariance with general…”
Get full text

Effects of alteplase on survival after ischaemic stroke (IST-3): 3 year follow-up of a randomised, controlled, open-label trial by Berge, Eivind, Prof, Cohen, Geoffrey, MSc, Roaldsen, Melinda B, MD, Lundström, Erik, MD, Isaksson, Eva, BN, Rudberg, Ann-Sofie, MD, Slot, Karsten Bruins, MD, Forbes, John, Prof, Smith, Joel, PhD, Drever, Jonathan, BSc, Wardlaw, Joanna M, Prof, Lindley, Richard I, Prof, Sandercock, Peter A G, Prof, Whiteley, William N, MD

“…Summary Background The effect of alteplase on patient survival after ischaemic stroke is the subject of debate. We report the effect of intravenous alteplase…”
Get full text

Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? by Wardlaw, J M, Sandercock, P A G, Dennis, M S, Starr, J

“…The pathogenesis of and relationship between small deep (lacunar) infarcts, cerebral white matter disease (leukoaraiosis or white matter hyperintensities), and…”
Get full text

Mechanisms underlying sporadic cerebral small vessel disease: insights from neuroimaging by Wardlaw, JM, Smith, C, Dichgans, M

“…The term “cerebral small vessel disease” (SVD) describes a range of neuroimaging, pathological and associated clinical features. The latter range from none, to…”
Get full text