Search Results - "Warder, S."

Conformational Changes in Conantokin-G Induced upon Binding of Calcium and Magnesium as Revealed by NMR Structural Analysis by Chen, Z, Blandl, T, Prorok, M, Warder, S E, Li, L, Zhu, Y, Pedersen, L G, Ni, F, Castellino, F J

“…The apo- and metal-bound solution conformations of synthetic conantokin-G (con-G, G 1 EγγL 5 QγNQγ 10 LIRγK 15 SN-CONH 2 , γ = γ-carboxyglutamic acid),…”
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MAST neutral beam long pulse upgrade by Gee, S.J., Baldwin, R., Borthwick, A., Ciric, D., Crawford, G., Hackett, L., Homfray, D., Martin, D., Milnes, J., Mutters, T., Simmonds, M., Smith, R., Stephen, R., Stevenson, P., Surrey, E., Waldon, C., Warder, S., Whitehead, A., Young, D.

“…Until summer 2003 two Neutral Beam Injectors (NBI), each equipped with one duopigatron ion source on loan from Oak Ridge National Laboratory (ORNL), were…”
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Effects of eye position on saccadic eye movements and on the neuronal responses to auditory and visual stimuli in cat superior colliculus by PECK, C. K, BARO, J. A, WARDER, S. M

“…Many neurons in the deeper layers of the superior colliculus (SC) respond to multiple sensory inputs--visual, auditory, and somatic--as well as provide signals…”
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Calcium Binding Properties of Synthetic γ-Carboxyglutamic Acid-Containing Marine Cone Snail “Sleeper” Peptides, Conantokin-G and Conantokin-T by Prorok, Mary, Warder, Scott E, Blandl, Tamas, Castellino, Francis J

“…Total chemical synthesis of two Conus-derived peptides, conantokin-G (con-G), a 17-residue polypeptide containing five residues of γ-carboxyglutamic acid…”
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Structure–function relationships of the NMDA receptor antagonist peptide, conantokin-R by Blandl, Tamas, Warder, Scott E, Prorok, Mary, Castellino, Francis J

“…Conantokin-R (con-R) is a γ-carboxyglutamate-containing 27-residue neuroactive peptide present in the venom of Conus radiatus, and acts as a non-competitive…”
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Amino acid determinants for NMDA receptor inhibition by conantokin‐T by Warder, Scott E., Blandl, Tamas, Klein, Rebecca C., Castellino, Francis J., Prorok, Mary

“…Several derivatives of conantokin‐T (con‐T), a naturally occurring, γ‐carboxyglutamate (Gla)‐containing peptide with NMDA receptor (NMDAR) antagonist…”
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The MAST neutral beam injection system by Nightingale, M.P.S, Crawford, G.W, Gee, S.J, Hurford, D.J, Martin, D, Simmonds, M.R, Smith, R.T.C, Tsai, C.C, Warder, S.E.V

“…Two neutral beam injectors will provide both plasma heating and current drive on the MAST tokamak using beamlines on loan from Oak Ridge National Laboratory…”
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An internal histidine residue from the bacterial surface protein, PAM, mediates its binding to the kringle-2 domain of human plasminogen by Schenone, M.M., Warder, S.E., Martin, J.A., Prorok, M., Castellino, F.J.

“…: The determinants of binding of a peptide lacking C‐termini‐exposed lysine residues to a kringle domain were investigated using an up‐regulated lysine binding…”
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Kinetic and mechanistic characterization of NMDA receptor antagonism by replacement and truncation variants of the conantokin peptides by Klein, Rebecca C., Warder, Scott E., Galdzicki, Zygmunt, Castellino, Francis J., Prorok, Mary

“…The characterization of conantokin-T (con-T), conantokin-R (con-R), and variants thereof, using the whole-cell patch clamp technique, was undertaken to…”
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Screening Strategies and Methods for Better Off-Target Liability Prediction and Identification of Small-Molecule Pharmaceuticals by Van Vleet, Terry R, Liguori, Michael J, Lynch, 3rd, James J, Rao, Mohan, Warder, Scott

“…Pharmaceutical discovery and development is a long and expensive process that, unfortunately, still results in a low success rate, with drug safety continuing…”
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Binding of cations to individual gamma-carboxyglutamate residues of conantokin-G and conantokin-T by Blandl, T., Warder, S.E., Prorok, M., Castellino, F.J.

“…: Conantokin‐G (con‐G) and conantokin‐T (con‐T) are naturally occurring γ‐carboxyglutamate (Gla)‐containing peptides that interact with multivalent cations in…”
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The roles of individual gamma-carboxyglutamate residues in the solution structure and cation-dependent properties of conantokin-T by Warder, S E, Prorok, M, Chen, Z, Li, L, Zhu, Y, Pedersen, L G, Ni, F, Castellino, F J

“…The solution structure of the Ca2+-loaded conantokin-T (con-T), a gamma-carboxyglutamate (Gla)-containing 21-residue peptide…”
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The NMR solution structure of the NMDA receptor antagonist, conantokin-T, in the absence of divalent metal ions by Warder, Scott E, Chen, Zhigang, Zhu, Yi, Prorok, Mary, Castellino, Francis J, Ni, Feng

“…The solution conformation of conantokin-T, a Gla-containing 21-residue peptide, (G 1EγγY 5QKMLγ 10NLRγA 15EVKKN 20A-amide), in the absence of divalent metal…”
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Nearshore tsunami amplitudes across the Maldives archipelago due to worst-case seismic scenarios in the Indian Ocean by Rasheed, Shuaib, Warder, Simon C, Plancherel, Yves, Piggott, Matthew D

“…The Maldives face the threat of tsunamis from a multitude of sources. However, the limited availability of critical data, such as bathymetry (a recurrent…”
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A straightforward approach to the synthesis of the tricyclic core of taxol by Wang, Zhaoyin, Warder, Scott E, Perrier, Helene, Grimm, Erich L, Bernstein, Michael A, Ball, Richard G

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Sensory integration in the deep layers of superior colliculus by Peck, C K, Baro, J A, Warder, S M

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Response of tidal flow regime and sediment transport in North Malé Atoll, Maldives, to coastal modification and sea level rise by Rasheed, Shuaib, Warder, Simon C., Plancherel, Yves, Piggott, Matthew D.

“…Changes to coastlines and bathymetry alter tidal dynamics and associated sediment transport processes, impacting upon a number of threats facing coastal…”
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Environmental Education and Attitude Change by Perdue, Richard R., Warder, Donald S.

“…Research was initiated to assess the degree to which participation in an environmental living practicum contributes to the development of environmental…”
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The entire gamma-carboxyglutamic acid- and helical stack-domains of human coagulation factor IX are required for optimal binding to its endothelial cell receptor by Prorok, M, Geng, J P, Warder, S E, Castellino, F J

“…The minimal region of the gamma-carboxyglutamic acid (Gla) domain of human factor (f) IX that interacted with its putative bovine aortic endothelial cell…”
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Design and commissioning of the MAST neutral beam power supplies for the long pulse beam upgrade by Stevenson, P., Vadgama, A.P., Dunkley, V.P., Warder, S.E.V., Baldwin, R.E.

“…The original beam injection system used in the Mega Amp Spherical Tokamak (MAST) at Culham was unable to deliver the long pulse plasma heating required to…”
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