Search Results - "Wardale, J."

The effects of scaffold architecture and fibrin gel addition on tendon cell phenotype by Pawelec, K. M., Wardale, R. J., Best, S. M., Cameron, R. E.

“…Development of tissue engineering scaffolds relies on careful selection of pore architecture and chemistry of the cellular environment. Repair of skeletal soft…”
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An ex vivo model using human osteoarthritic cartilage demonstrates the release of bioactive insulin-like growth factor-1 from a collagen-glycosaminoglycan scaffold by Wardale, J., Mullen, L., Howard, D., Ghose, S., Rushton, N.

“…  Biomimetic scaffolds hold great promise for therapeutic repair of cartilage, but although most scaffolds are tested with cells in vitro, there are very few…”
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Changes in htra1 in cartilage after single impact loading by Hernandez, P, Wardale, J, Rushton, N, Henson, F

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Scaffold architecture and fibrin gels promote meniscal cell proliferation by Pawelec, K. M., Best, S. M., Cameron, R. E., Wardale, R. J.

“…Stability of the knee relies on the meniscus, a complex connective tissue with poor healing ability. Current meniscal tissue engineering is inadequate, as the…”
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Does titin regulate the length of muscle thick filaments? by Whiting, A, Wardale, J, Trinick, J

“…The protein titin has been localized by electron microscopy of myofibrils labelled with monoclonal antibodies. The data are consistent with individual titin…”
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Up-Regulation of Matrix Metalloproteinase Expression and Activation Following Cyclical Compressive Loading of Articular Cartilage in Vitro by Blain, E.J., Gilbert, S.J., Wardale, R.J., Capper, S.J., Mason, D.J., Duance, V.C.

“…Osteoarthritis (OA) results in articular cartilage degeneration and subchondral bone remodeling. Excessive or abnormal loading of the joint may contribute to…”
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Ionic solutes impact collagen scaffold bioactivity by Pawelec, K. M., Husmann, A., Wardale, R. J., Best, S. M., Cameron, R. E.

“…The structure of ice-templated collagen scaffolds is sensitive to many factors. By adding 0.5 wt% of sodium chloride or sucrose to collagen slurries, scaffold…”
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A regular pattern of two types of 100-residue motif in the sequence of titin by Labeit, S, Barlow, D. P, Gautel, M, Gibson, T, Holt, J, Hsieh, C.-L, Francke, U, Leonard, K, Wardale, J, Whiting, A, Trinick, J

“…Titin is the largest polypeptide yet described (relative molecular mass approximately 3 x 10(6); refs 1, 2) and an abundant protein of striated muscle. Its…”
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Evidence that nebulin is a protein-ruler in muscle thin filaments by Labeit, S., Gibson, T., Lakey, A., Leonard, K., Zeviani, M., Knight, P., Wardale, J., Trinick, J.

“…Partial amino acid sequence was obtained from the massive myofibrillar protein nebulin. This consists of repeating motifs of about 35 residues and…”
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Type II collagen deposition in cruciate ligament precedes osteoarthritis in the guinea pig knee by Young, R.D., Vaughan-Thomas, A., Wardale, R.J., Duance, V.C.

“…Objective To examine the collagens in cruciate ligaments of young Dunkin-Hartley guinea pigs, to determine whether a change in specific collagen types is an…”
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Characterisation of articular and growth plate cartilage collagens in porcine osteochondrosis by WARDALE, R. J, DUANCE, V. C

“…The articular and growth plate cartilages of osteochondrotic pigs were examined and compared with those from clinically normal animals. Both types of…”
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Effect of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide concentrations on the mechanical and biological characteristics of cross-linked collagen fibres for tendon repair by Ahmad, Zafar, Shepherd, Jennifer H., Shepherd, David V., Ghose, Siddhartha, Kew, Simon J., Cameron, Ruth E., Best, Serena M., Brooks, Roger A., Wardale, John, Rushton, Neil

“…Reconstituted type I collagen fibres have received considerable interest as tendon implant materials due to their chemical and structural similarity to the…”
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Effectiveness of a quality improvement collaborative in reducing time to surgery for patients requiring emergency cholecystectomy by Bamber, J. R., Stephens, T. J., Cromwell, D. A., Duncan, E., Martin, G. P., Quiney, N. F., Abercrombie, J. F., Beckingham, I. J., Abraham, J., Ahmad, I., Ahmed, J., Andrews, M., Appleton, B., Asif, M., Bolton, R., Briggs, C., Bumagat, U., Burchfield, S., Cochrane, G., Dewi, F., Dovell, G., Dyer, S., Edge, J., Edwards, R., Fabre, I., Gemmill, E., Griffiths, E., Hariharan, D., Harrington‐Patel, E., Hassn, A., Hepworth, M., Hewes, J., Hine, S., Hollyman, M., Ide, K., Jenner, D., Johnson, R., Jordan, S., Karamanakos, S., Kovoor, J., Kukreja, N., Marangoni, G., Metcalfe, N., Morcous, P., Needham, P., Patel, N., Qureshi, N., Rajaretnam, N., Rajendran, I., Sabah, Y., Sanders, D. L., Sandison, A., Sansom, J., Seth, R., Shetty, V., Sollei, T., Strong, S., Sullivan, L., Sutcliffe, R. P., Talbot, L., Taylor, G., Varadarajan, V., Villatoro, E., Wardale, J., Weaver, S., Wiggins, T., Wood, A.

“…Background Acute gallstone disease is a high‐volume emergency general surgery presentation with wide variations in the quality of care provided across the UK…”
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Binding and release characteristics of insulin-like growth factor-1 from a collagen-glycosaminoglycan scaffold by Mullen, Leanne M, Best, Serena M, Brooks, Roger A, Ghose, Siddhartha, Gwynne, Jessica H, Wardale, John, Rushton, Neil, Cameron, Ruth E

“…Tissue engineering is a promising technique for cartilage repair, but to optimize novel scaffolds before clinical trials, it is necessary to determine their…”
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Differential scanning calorimetric studies of superficial digital flexor tendon degeneration in the horse by Miles, C A, Wardale, R J, Birch, H L, Bailey, A J

“…Differential scanning calorimetry (DSC) of equine superficial digital flexor tendons revealed the presence of a small exothermic peak at 23 degrees C of…”
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The application of scanning confocal microscopy in cartilage research by Wotton, S F, Jeacocke, R E, Maciewicz, R A, Wardale, R J, Duance, V C

“…Scanning confocal microscopy has been used in conjunction with immunofluorescent localization to address two areas of debate in cartilage research. With the…”
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The mononuclear cell population in rat leg muscle: its contribution to the lysosomal enzyme activities of whole muscle extracts by Etherington, D J, Wardale, R J

“…The mononuclear cell fraction of rat hind-limb muscle was obtained by digestion with clostridial collagenase in the presence of calcium ions, filtration…”
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Immunodetection of cathepsins B and L present in and secreted from human pre-malignant and malignant colorectal tumour cell lines by Maciewicz, R A, Wardale, R J, Etherington, D J, Paraskeva, C

“…Pre-malignant and malignant human colorectal tumour epithelial cell lines both secreted precursor forms of the 2 cysteine proteinases, cathepsins B and L. The…”
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Emendations by Wardale, J. R.

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Quantification and immunolocalisation of porcine articular and growth plate cartilage collagens by Wardale, R J, Duance, V C

“…The collagens of growth plate and articular cartilage from 5-6 month old commercial pigs were characterised. Growth plate cartilage was found to contain less…”
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