Stress resilience is an active and multifactorial process manifested by structural, functional, and molecular changes in synapses

Stress resilience is the ability of neuronal networks to maintain their function despite the stress exposure. Using a mouse model we investigate stress resilience phenomenon. To assess the resilient and anhedonic behavioral phenotypes developed after the induction of chronic unpredictable stress, we...

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Published in:	Neurobiology of stress Vol. 33; p. 100683
Main Authors:	Bączyńska, E., Zaręba-Kozioł, M., Ruszczycki, B., Krzystyniak, A., Wójtowicz, T., Bijata, K., Pochwat, B., Magnowska, M., Roszkowska, M., Figiel, I., Masternak, J., Pytyś, A., Dzwonek, J., Worch, R., Olszyński, K.H., Wardak, A.D., Szymczak, P., Labus, J., Radwańska, K., Jahołkowski, P., Hogendorf, A., Ponimaskin, E., Filipkowski, R.K., Szewczyk, B., Bijata, M., Włodarczyk, J.
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01-11-2024 Elsevier
Subjects:	Behavioral stress response Chronic unpredictable stress Dendritic spines Palmitoylation Stress-resilient animals Dendritic spines Chronic unpredictable stress Behavioral stress response Palmitoylation Stress-resilient animals
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Summary:	Stress resilience is the ability of neuronal networks to maintain their function despite the stress exposure. Using a mouse model we investigate stress resilience phenomenon. To assess the resilient and anhedonic behavioral phenotypes developed after the induction of chronic unpredictable stress, we quantitatively characterized the structural and functional plasticity of excitatory synapses in the hippocampus using a combination of proteomic, electrophysiological, and imaging methods. Our results indicate that stress resilience is an active and multifactorial process manifested by structural, functional, and molecular changes in synapses. We reveal that chronic stress influences palmitoylation of synaptic proteins, whose profiles differ between resilient and anhedonic animals. The changes in palmitoylation are predominantly related with the glutamate receptor signaling thus affects synaptic transmission and associated structures of dendritic spines. We show that stress resilience is associated with structural compensatory plasticity of the postsynaptic parts of synapses in CA1 subregion of the hippocampus. One Sentence Summary: Compensatory remodeling of dendritic spines at the structural and molecular levels underlies stress resilience.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2352-2895 2352-2895
DOI:	10.1016/j.ynstr.2024.100683